The DOI matches its Crossref record.
Effect of Antioxidants and Nutrients on Lipid Peroxidation Fluorescent Products and Aging Parameters in the Mouse
Abstract
The effect of dietary antioxidants and nutrients, including vitamin E, butylated hydroxytoluene, selenium, ascorbic acid, and methionine, on various aging parameters was studied. Starting at an age of 9 mo., mice were separated into 3 dietary groups: I control diet group and 2 dietary groups with the above antioxidant components added at different levels. The animals were fed these diets up to 1.9 years, and during this period the following age-related parameters were measured: accumulation of fluorescent aging pigments, calcium uptake in muscle microsomes, kidney function, mortality rates, and voluntary and forced activity. Of the 3 diets, the one supplemented with high levels of antioxidants significantly inhibited accumulation of fluorescent products in testes and heart, while the mortality rate and other age-related indices were not affected. Statistical analysis of data suggests that fluorescent pigment accumulation is an inverse linear function of the log of the dietary antioxidant and an exponential function of age.
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Cited by
Bilirubin Is an Antioxidant of Possible Physiological Importance
Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., & Ames, B. N. (1987) · Science · doi:10.1126/science.3029864 · Cited by 2,948
Harman, D. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7124 · Cited by 1,915
Harman, D. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90030-s · Cited by 902
Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster
Miquel, J., Lundgren, P. R., Bensch, K. G., & Atlan, H. (1976) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(76)90034-8 · Cited by 342
Barja, G. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5148 · Cited by 290
Metadata
- Authors
- Tappel, A., Fletcher, B., & Deamer, D.
- Venue
- Journal of Gerontology
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-10-01
- Volume
- 28
- Issue
- 4
- Pages
- 415-424
- ISSN
- 0022-1422 (ISSN-L)
- OpenAlex
- W2082722544
- Cited by
- 224
- References
- 0
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tappel, A., Fletcher, B., & Deamer, D. (1973). Effect of Antioxidants and Nutrients on Lipid Peroxidation Fluorescent Products and Aging Parameters in the Mouse. Journal of Gerontology. https://doi.org/10.1093/geronj/28.4.415
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