Free radical theory of aging
Abstract
Free radical reactions are ubiquitous in living things. Studies on the origin and evolution of life provide a reasonable explanation for the prominent presence of this unruly class of chemical reactions. These reactions have been implicated in aging. This phenomenon is the accumulation of changes responsible for the sequential alterations that accompany advancing age and the associated progressive increases in the chance of disease and death. Aging changes are attributed to the environment and disease, and to an inborn process, the aging process. The latter produces aging changes at an exponentially increasing rate with advancing age. Past improvements in general living conditions have decreased the chances for death so that they are now near limiting values in the developed countries. In these countries the intrinsic aging process is the major cause of disease and death after about age 28. The free radical theory of aging postulates that aging changes are caused by free radical reactions. The data supporting this theory indicate that average life expectancy at birth may be increased by 5 or more years, by nutritious low caloric diets supplemented with one or more free radical reaction inhibitors.
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Oxidative stress induced by reactive oxygen species plays an important role in human skin ageing.
“There is extensive evidence indicating that oxidative stress induced by reactive oxygen species plays an important role in the process of human skin ageing.”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [14]
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- Authors
- Harman, D.
- Affiliations
- University of Nebraska Medical Center (US)
- Corresponding author
- Harman, Denham
- Venue
- Mutation Research/DNAging
- Publisher
- Elsevier BV
- Published
- 1992-09
- Volume
- 275
- Issue
- 3-6
- Pages
- 257-266
- ISSN
- 0921-8734 (ISSN-L)
- OpenAlex
- W2089939834
- Cited by
- 902
- References
- 100
- Citations by year
- 2026: 9 · 2025: 25 · 2024: 18 · 2023: 25 · 2022: 22 · 2021: 26 · 2020: 35 · 2019: 36 · 2018: 32 · 2017: 23 · 2016: 27 · 2015: 31 · 2014: 36 · 2013: 26 · 2012: 36
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mutation Research/DNAging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- free radical theory of aging, radical reactions, intrinsic aging, life expectancy, radical scavengers, aging and disease
- MeSH terms
- Aging, Animals, Antioxidants, Diet, Biological Evolution, Female, Free Radicals, Humans, Longevity, Male, Models, Biological, Sex Characteristics
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