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The Response of Arginine Vasopressin to Intravenous Ethanol and Hypertonic Saline in Man: The Impact of Aging
Abstract
The effect of age on the hypothalamic-hypophyseal-renal axis in normal man was determined by assaying plasma arginine vasopressin (AVP) responses to inhibitory and to secretory stimuli. Nine young (21-49 years) and 13 old (54-92 years) subjects received IV ethanol (375 mg/m2 per min). AVP levels fell progressively during the infusion in the young group, but fell for only 30 min in the old group and then rose paradoxically despite the continuing increase in blood ethanol. Eight young (22-48 years) and 8 old (52-66 years) men were provided identical osmolal loads by a 2-hour IV infusion of 3% NaCl at 0.1 ml/kg per min. Serum AVP rose 2.5 times the baseline in the young and 4.5 times the baseline in the old men despite identical free water clearances. Osmoreceptor sensitivity (the slope of AVP on osmolality) was greater in the old subjects. The heightened sensitivity to hyperosomolality helps examine the paradoxical response to ethanol, since osmolality increased during that time. This increased AVP response may severe to compensate for the reduced renal ability to conserve salt and water in aging man.
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Cited by
Vasopressin and disorders of water balance: the physiology and pathophysiology of vasopressin
Ball, S. G. (2007) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1258/000456307781646030 · Cited by 110
Electrolyte Disturbances in Patients with Chronic Alcohol-Use Disorder
Palmer, B. F., & Clegg, D. J. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1704724 · Cited by 111
Yatagai, T., Kusaka, I., Nakamura, T., Nagasaka, S., Honda, K., Ishibashi, S., & Ishikawa, S. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480221 · Cited by 55
Chapter 9 Neuropeptide changes in aging and Alzheimer's disease
(1986) · Progress in Brain Research · doi:10.1016/s0079-6123(08)64302-2 · Cited by 20
Metadata
- Authors
- Helderman, J. H., Vestal, R. E., Rowe, J. W., Tobin, J. D., Andres, R., & Robertson, G. L.
- Venue
- Journal of Gerontology
- Publisher
- Oxford University Press (OUP)
- Published
- 1978-01-01
- Volume
- 33
- Issue
- 1
- Pages
- 39-47
- ISSN
- 0022-1422 (ISSN-L)
- OpenAlex
- W2057462579
- Cited by
- 309
- References
- 0
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Response of Arginine Vasopressin to Intravenous Ethanol and Hypertonic Saline in Man: The Impact of Aging. https://app.cochat.ai/papers/10.1093/geronj/33.1.39
- The paper
- Helderman, J. H., Vestal, R. E., Rowe, J. W., Tobin, J. D., Andres, R., & Robertson, G. L. (1978). The Response of Arginine Vasopressin to Intravenous Ethanol and Hypertonic Saline in Man: The Impact of Aging. Journal of Gerontology. https://doi.org/10.1093/geronj/33.1.39
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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