The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Glycobiology of sperm-egg interactions in deuterostomes
Abstract
The process of fertilization begins when sperm contact the outermost egg investment and ends with fusion of the two haploid pronuclei in the egg cytoplasm. Many steps in fertilization involve carbohydrate-based molecular recognition between sperm and egg. Although there is conservation of gamete recognition molecules within vertebrates, their homologues have not yet been discovered in echinoderms and ascidians (the invertebrate deuterostomes). In echinoderms, long sulfated polysaccharides act as ligands for sperm receptors. Ascidians employ egg coat glycosides that are recognized by sperm surface glycosidases. Vertebrate egg coats contain zona pellucida (ZP) family glycoproteins, whose carbohydrates bind to sperm receptors. Several candidate sperm receptors for vertebrate ZP proteins have been identified and are discussed here. This brief review focuses on new information concerning fertilization in deuterostomes (the phylogenetic group including echinoderms, ascidians, and vertebrates) and highlights protein-carbohydrate interactions involved in this process.
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“Many early studies suggested that glycan-recognition processes were a critical part of many sperm -egg interactions (75, 938 -939).”
From Biological roles of glycans (2017) · cites this paper as [75]
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Cited by
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“critical part of many sperm-egg interactions (73, 938, 939).”
BackgroundHuman Sperm Binding Is Mediated by the Sialyl-Lewis x Oligosaccharide on the Zona Pellucida
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Metadata
- Authors
- Mengerink, K. J., & Vacquier, V. D.
- Affiliations
- Scripps Institution of Oceanography (US)
- Venue
- Glycobiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-04-01
- Volume
- 11
- Issue
- 4
- Pages
- 37R-43R
- ISSN
- 0959-6658 (ISSN-L)
- 1460-2423
- OpenAlex
- W2119462264
- Cited by
- 103
- References
- 96
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Glycobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-12986)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Keywords
- sperm-egg interaction, fertilisation (biology), deuterostomes, Echinodermata, ascidians, zona pellucida, sperm receptor, sulfated polysaccharides, carbohydrate-protein interactions, gamete recognition
- MeSH terms
- Animals, Echinodermata, Female, Male, Membrane Glycoproteins, Ovum, Receptors, Cell Surface, Sperm-Ovum Interactions, Spermatozoa, Urochordata, Vertebrates, Zona Pellucida
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