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Hyaluronan promotes the malignant phenotype
Abstract
Hyaluronan is a high-molecular-weight, negatively charged polysaccharide with unusual physical and interactive properties. Hyaluronan is localized in the extracellular matrix, at the cell surface, and inside cells. Its tissue distribution is ubiquitous, but it is particularly concentrated in pericellular matrices surrounding proliferating and migrating cells. Hyaluronan contributes to cell behavior in at least three ways. Its unique physical properties influence the biomechanical properties of extracellular and pericellular matrices; it is a template for assembly of other pericellular macromolecules; and it interacts directly with cell surface receptors that transduce intracellular signals. Experimental studies in animal models have documented a crucial role for hyaluronan in tumor growth and metastasis. Cellular manipulations have shown that hyaluronan promotes anchorage-independent growth and invasiveness, hallmarks of the malignant phenotype.
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Camenisch, T. D., Spicer, A. P., Brehm-Gibson, T., Biesterfeldt, J., Augustine, M. L., Calabro, A., Kubalak, S., Klewer, S. E., & McDonald, J. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10272 · Cited by 901
DeAngelis, P. L. (1999) · Cellular and Molecular Life Sciences CMLS · doi:10.1007/s000180050461 · Cited by 207
Cited by
Wiig, H., & Swartz, M. A. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2011 · Cited by 722
Harada, H., & Takahashi, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608358200 · Cited by 320
Gelatine Methacrylamide-Based Hydrogels: An Alternative Three-Dimensional Cancer Cell Culture System
Kaemmerer, E., Melchels, F. P. W., Holzapfel, B. M., Meckel, T., Hutmacher, D. W., & Loessner, D. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.02.035 · Cited by 219
Chen, Y.-Y., Wu, H.-C., Sun, J.-S., Dong, G.-C., & Wang, T.-W. (2013) · Langmuir · doi:10.1021/la400268p · Cited by 126
Ramamonjisoa, N., & Ackerstaff, E. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00003 · Cited by 93
Metadata
- Authors
- Toole, B. P.
- Venue
- Glycobiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-03-01
- Volume
- 12
- Issue
- 3
- Pages
- 37R-42R
- ISSN
- 0959-6658 (ISSN-L)
- 1460-2423
- OpenAlex
- W2069361749
- Cited by
- 200
- References
- 2
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
