Injectable and Thermoresponsive Self-Assembled Nanocomposite Hydrogel for Long-Term Anticancer Drug Delivery
Abstract
The purpose of this study is to develop an injectable thermoresponsive hydrogel system that can undergo sol-gel phase transition by the stimulation of body temperature with improved mechanical stability and biocompatibility as a controlled drug delivery carrier for cancer therapy. Hexamethylene diisocyanate (HDI) was introduced into Pluronic F127 as a chain extender to improve the mechanical stability. HDI-Pluronic F127 copolymer was then incorporated with hyaluronic acid to develop a thermoresponsive nanocomposite hydrogel system. The physiochemical properties were characterized. The anticancer drug release profile and effect to inhibit tumor cells growth were analyzed in vitro and in vivo. The results showed that HDI-Pluronic F127/hyaluronic acid thermoresponsive hydrogel could undergo sol-gel transition as temperature increased to 37 °C. The nanocomposite polymer can spontaneously self-assemble into micellar structure with size of 100-200 nm. The release of doxorubicin (DOX) from HDI-PF127/HA composite hydrogel was a zero-order profile and maintained sustained release for over 28 days. The viability of tumor cells and size of tumor significantly decreased with incubation time, indicating the potential to have a therapeutic effect for cancer therapy. The injectable thermoresponsive nanocomposite hydrogel system was biocompatible and degradable and had the slow controlled release property for anticancer drugs with potential applications in the field of drug delivery.
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Thermosensitive HDI-PF127/HA hydrogel possessed adequate physiochemical and biological properties and was used as a delivery carrier for sustained release of anticancer drugs in cancer therapy.
“This thermosensitive HDI-PF127/HA hydrogel possessed adequate physiochemical and biological properties and was used as a delivery carrier for the sustained release of anticancer drugs in cancer therapy.254”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [254]
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Retracted
- Authors
- Chen, Y.-Y., Wu, H.-C., Sun, J.-S., Dong, G.-C., & Wang, T.-W.
- Affiliations
- Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, Taiwan
- Tatung University (TW)
- National Taiwan University Hospital (TW)
- National Health Research Institutes (TW)
- National Tsing Hua University (TW)
- Corresponding author
- Wang, Tzu-Wei
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-03-07
- Volume
- 29
- Issue
- 11
- Pages
- 3721-3729
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2016248311
- Cited by
- 126
- References
- 36
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 3 · 2023: 11 · 2022: 5 · 2021: 10 · 2020: 7 · 2019: 10 · 2018: 17 · 2017: 13 · 2016: 10 · 2015: 15 · 2014: 9 · 2013: 1
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Langmuir (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Keywords
- thermosensitive hydrogel, injectable hydrogel, self-assembly, nanocomposite hydrogels, Pluronic F127, hexamethylene diisocyanate, hyaluronic acid, sol-gel transition, doxorubicin release, sustained drug release, controlled drug delivery, anticancer drug delivery, tumor growth inhibition, biocompatibility, mechanical stability
- MeSH terms
- Animals, Antineoplastic Agents, Cyanates, Doxorubicin, Drug Carriers, Humans, Injections, Male, Materials Testing, Micelles, Rheology, Temperature, Isocyanates, Hydrogels, Poloxamer, Phase Transition, Cell Proliferation, Mice, Nanocomposites, MCF-7 Cells
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