Polysialyltransferase overexpression in Schwann cells mediates different effects during peripheral nerve regeneration
Abstract
The polysialic acid (PSA) moiety of the neural cell adhesion molecule (NCAM) has been shown to support dynamic changes underlying peripheral nerve regeneration. Using transgenic mice expressing polysialyltransferase ST8SiaIV under control of a glial-specific (proteolipid protein, PLP) promoter (PLP-ST8SiaIV-transgenic mice), we tested the hypothesis that permanent synthesis of PSA in Schwann cells impairs functional recovery of lesioned peripheral nerves. After sciatic nerve crush, histomorphometric analyses demonstrated impaired remyelination of regenerated axons at the lesion site and in target tissue of PLP-ST8SiaIV-transgenic mice, though the number and size of regenerating unmyelinated axons were not changed. This was accompanied by slower mechanosensory recovery in PLP-ST8SiaIV-transgenic mice. However, the proportion of successfully mono-(re)innervated motor endplates in the foot pad muscle was significantly increased in PLP-ST8SiaIV-transgenic mice when compared with wild-type littermates, suggesting that long-term increase in PSA levels in regenerating nerves may favor selective motor target reinnervation. The combined negative and positive effects of a continuous polysialyltransferase overexpression observed during peripheral nerve regeneration suggest that an optimized time- and differentiation-dependent control of polysialyltransferase expression in Schwann cells may further improve recovery after peripheral nerves injury.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The plasticity resulting from polysialic acid expression appears to be important for neuronal migration and for reorganization following injury.
“The ' plasticity ' resulting from polysialic acid expression appears to be important for neuronal migration as well as reorganization following injury (546 -554).”
From Biological roles of glycans (2017) · cites this paper as [552]
Cites
Polysialic acid in the plasticity of the developing and adult vertebrate nervous system
Rutishauser, U. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2285 · Cited by 584 · see citing works
Altered expression of neuronal cell adhesion molecules induced by nerve injury and repair.
Daniloff, J. K., Levi, G., Grumet, M., et al. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.3.929 · Cited by 314 · see citing works
Charles, P., Hernandez, M. P., Stankoff, B., Aigrot, M. S., Colin, C., Rougon, G., Zalc, B., & Lubetzki, C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100076197 · Cited by 306 · see citing works
Rich, M., & Lichtman, J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-05-01781.1989 · Cited by 294 · see citing works
Molecular characterization of eukaryotic polysialyltransferase-1
Eckhardt, M., Mühlenhoff, M., Bethe, A., Koopman, J., Frosch, M., & Gerardy‐Schahn, R. (1995) · Nature · doi:10.1038/373715a0 · Cited by 285 · see citing works
Self-citationFawcett, J. W. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.13.1.43 · Cited by 281 · see citing works
Curreli, S., Arany, Z., Gerardy‐Schahn, R., Mann, D. L., & Stamatos, N. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702965200 · Cited by 197 · see citing works
Koning, P. D., Brakkee, J. H., & Gispen, W. H. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90109-7 · Cited by 187 · see citing works
Guntinas‐Lichius, O., Irintchev, A., Streppel, M., et al. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03877.x · Cited by 182 · see citing works
Maurel, P., Einheber, S., Galinska, J., Thaker, P., Lam, I., Rubin, M. B., Scherer, S. S., Murakami, Y., Gutmann, D. H., & Salzer, J. L. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705132 · Cited by 177 · see citing works
Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain
Galuska, S. P., Rollenhagen, M., Kaup, M., Eggers, K., Oltmann‐Norden, I., Schiff, M., Hartmann, M., Weinhold, B., Hildebrandt, H., Geyer, R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912103107 · Cited by 165 · see citing works
Robinson, C. P., Hundson, L., Ono, K., Friedrich, V. L., Benecke, J., Dubois-Dalcq, M. E., & Lazzarini, R. A. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180402 · Cited by 157 · see citing works
Nait‐Oumesmar, B., Vignais, L., Clérin, E., Avellana‐Adalid, V., Rougon, G. N., & Evercooren, A. B. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00344.x · Cited by 139 · see citing works
Franz, C. K., Rutishauser, U. S., & Rafuse, V. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4880-04.2005 · Cited by 130 · see citing works
Magill, C. K., Tong, A. Y., Kawamura, D. H., et al. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.028 · Cited by 128 · see citing works
Siconolfi, L. B., & Seeds, N. W. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04348.2001 · Cited by 126 · see citing works
Haastert‐Talini, K., Lipokatic-Takacs, E., Fischer, M., Timmer, M., & Grothe, C. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.06.020 · Cited by 122 · see citing works
Self-citationLi, W., Brakefield, D., Pan, Y., Hunter, D., Myckatyn, T. M., & Parsadanian, A. S. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.08.028 · Cited by 117 · see citing works
In VivoAutopolysialylation and Localization of the Polysialyltransferases PST and STX
Close, B. E., & Colley, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34586 · Cited by 109 · see citing works
Autocatalytic polysialylation of polysialyltransferase‐1.
Mühlenhoff, M., Eckhardt, M., Bethe, A., Frosch, M., & Gerardy‐Schahn, R. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01086.x · Cited by 106 · see citing works
Self-citationJungnickel, J., Haase, K., Konitzer, J., Timmer, M., & Grothe, C. (2006) · Journal of Neurobiology · doi:10.1002/neu.20265 · Cited by 100 · see citing works
Self-citationExpression of myelin protein genes in Schwann cells
Griffiths, I. R., Mitchell, L. S., McPhilemy, K., et al. (1989) · Journal of Neurocytology · doi:10.1007/bf01190837 · Cited by 99 · see citing works
Mehanna, A., Mishra, B., Kurschat, N., Schulze, C., Bian, S., Loers, G., Irintchev, A., & Schachner, M. (2009) · Brain · doi:10.1093/brain/awp128 · Cited by 95 · see citing works
Down-regulation of Polysialic Acid Is Required for Efficient Myelin Formation
Fewou, S. N., Ramakrishnan, H., Büssow, H., Gieselmann, V., & Eckhardt, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610797200 · Cited by 94 · see citing works
Self-citationHighly sialylated N-CAM is expressed in adult mouse optic nerve and retina
Bartsch, U., Kirchhoff, F., & Schachner, M. (1990) · Journal of Neurocytology · doi:10.1007/bf01257243 · Cited by 90 · see citing works
Zhang, Y., Campbell, G., Anderson, P. N., Martini, R., Schachner, M., & Lieberman, A. R. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903610202 · Cited by 89 · see citing works
Timmer, M., Robben, S., Müller-Ostermeyer, F., Nikkhah, G., & Grothe, C. (2003) · Cell Transplantation · doi:10.3727/000000003108746821 · Cited by 85 · see citing works
Self-citationNogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury
Pot, C., Simonen, M., Weinmann, O., Schnell, L., Christ, F., Wyss-Stoeckle, S., Berger, P., Rülicke, T., Suter, U., & Schwab, M. E. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200206068 · Cited by 84 · see citing works
Mehanna, A., Jakovčevski, I., Acar, A., Xiao, M.-F., Loers, G., Rougon, G. N., Irintchev, A., & Schachner, M. (2009) · Molecular Therapy · doi:10.1038/mt.2009.235 · Cited by 84 · see citing works
Intrinsic neuronal properties control selective targeting of regenerating motoneurons
Franz, C. K., Rutishauser, U. S., & Rafuse, V. F. (2008) · Brain · doi:10.1093/brain/awn039 · Cited by 83 · see citing works
Jakovčevski, I., Mo, Z., & Zečević, N. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.044 · Cited by 78 · see citing works
Lavdas, A. Α., Franceschini, I., Dubois-Dalcq, M. E., & Matsas, R. (2006) · Glia · doi:10.1002/glia.20340 · Cited by 78 · see citing works
Zhang, Y., Campbell, G., Anderson, P. N., Martini, R., Schachner, M., & Lieberman, A. R. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903610203 · Cited by 60 · see citing works
Boisseau, S., Nédelec, J., Poirier, V., et al. (1991) · Development · doi:10.1242/dev.112.1.69 · Cited by 58 · see citing works
Kawabuchi, M., Zhou, C. J., Wang, S., Nakamura, K., LIU, W., & Hirata, K. (2001) · The Anatomical Record · doi:10.1002/ar.1159 · Cited by 49 · see citing works
Targeted disruption of the FGF-2 gene affects the response to peripheral nerve injury
Jungnickel, J., Claus, P., Gransalke, K., Timmer, M., & Grothe, C. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.11.007 · Cited by 44 · see citing works
Self-citationFunakoshi, H., Risling, M., Carlstedt, T. P., Lendahl, U., Timmusk, T., METSIS, M. L., Yamamoto, Y., & Ibáñez, C. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5269 · Cited by 41 · see citing works
Koutsoudaki, P. N., Hildebrandt, H., Gudi, V., Skripuletz, T., Škuljec, J., & Stangel, M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.070 · Cited by 37 · see citing works
Effect of genetically modified Schwann cells with increased motility in end-to-side nerve grafting
Gravvanis, A. I., Lavdas, A. Α., Papalois, A. E., et al. (2005) · Microsurgery · doi:10.1002/micr.20141 · Cited by 37 · see citing works
Lino, M. M., Atanasoski, S., Kvajo, M., Fayard, B., Moreno, E., Brenner, H. R., Suter, U., & Monard, D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0277-07.2007 · Cited by 34 · see citing works
Eckhardt, M., Fewou, S. N., ACKERMANN, I., et al. (2002) · Biochemical Journal · doi:10.1042/bj20020946 · Cited by 32 · see citing works
Self-citationPeripheral nerve regeneration is delayed in neuropilin 2–deficient mice
Bannerman, P. G. C., Ara, J. E., Hahn, A., Hong, L., McCauley, E., Friesen, K., & Pleasure, D. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21766 · Cited by 28 · see citing works
Tacke, R., & Martini, R. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90045-b · Cited by 26 · see citing works
Level and localization of polysialic acid is critical for early peripheral nerve regeneration
Jungnickel, J., Brämer, C. H., Bronzlik, P., Lipokatic-Takacs, E., Weinhold, B., Gerardy‐Schahn, R., & Grothe, C. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.12.003 · Cited by 24 · see citing works
Self-citationLevels of Proteolipid Protein mRNAs in Peripheral Nerve Are Not Under Stringent Axonal Control
Gupta, S. K., Pringle, J., Poduslo, J. F., et al. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02077.x · Cited by 23 · see citing works
Jiang, H., Duchala, C. S., Awatramani, R., Shumas, S. R., Carlock, L. R., Kamholz, J. A., Garbern, J. Y., Scherer, S. S., Shy, M. E., & Macklin, W. B. (2000) · Journal of Neurobiology · doi:10.1002/1097-4695(200007)44:1 · Cited by 22 · see citing works
Mice lacking basic fibroblast growth factor showed faster sensory recovery
Jungnickel, J., Haastert‐Talini, K., Grzybek, M., et al. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.06.003 · Cited by 19 · see citing works
Self-citationNeural Cell Adhesion Molecules
Tieu, K., & Yu, P. H. (2003) · Humana Press eBooks · doi:10.1385/0-89603-510-7:103 · Cited by 12 · see citing works
Wang, S., Kawabuchi, M., Zhou, C. J., et al. (2004) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2004.09304.x · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635 · see citing works
- Authors
- Jungnickel, J., Eckhardt, M., Haastert-Talini, K., Claus, P., Bronzlik, P., Lipokatic-Takacs, E., Maier, H., Gieselmann, V., & Grothe, C.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- University of Bonn (DE)
- Corresponding author
- Eckhardt, M.
- Grothe, C.
- Venue
- Glycobiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08-12
- Volume
- 22
- Issue
- 1
- Pages
- 107-115
- ISSN
- 0959-6658 (ISSN-L)
- 1460-2423
- OpenAlex
- W2319268555
- Cited by
- 18
- References
- 49
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Glycobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- polysialic acid, Schwann cells, peripheral nerve regeneration, sciatic nerve crush injury, remyelination, CD56, transgenic mice, axon regeneration
- MeSH terms
- Animals, Axons, Cell Count, Gene Expression Regulation, Mice, Inbred C57BL, Mice, Transgenic, Nerve Regeneration, Promoter Regions, Genetic, Recombinant Proteins, Schwann Cells, Sciatic Nerve, Sialic Acids, Sialyltransferases, Gene Expression, Muscle, Skeletal, Mice, Peripheral Nerve Injuries
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review