Cited by 18Nerve injury and regenerationGlycosylation and Glycoproteins ResearchPeripheral Neuropathies and Disorders

Polysialyltransferase overexpression in Schwann cells mediates different effects during peripheral nerve regeneration

Jungnickel, J., Eckhardt, M., Haastert-Talini, K., Claus, P., Bronzlik, P., Lipokatic-Takacs, E., Maier, H., Gieselmann, V. +1 more·2012·Glycobiology

Abstract

The polysialic acid (PSA) moiety of the neural cell adhesion molecule (NCAM) has been shown to support dynamic changes underlying peripheral nerve regeneration. Using transgenic mice expressing polysialyltransferase ST8SiaIV under control of a glial-specific (proteolipid protein, PLP) promoter (PLP-ST8SiaIV-transgenic mice), we tested the hypothesis that permanent synthesis of PSA in Schwann cells impairs functional recovery of lesioned peripheral nerves. After sciatic nerve crush, histomorphometric analyses demonstrated impaired remyelination of regenerated axons at the lesion site and in target tissue of PLP-ST8SiaIV-transgenic mice, though the number and size of regenerating unmyelinated axons were not changed. This was accompanied by slower mechanosensory recovery in PLP-ST8SiaIV-transgenic mice. However, the proportion of successfully mono-(re)innervated motor endplates in the foot pad muscle was significantly increased in PLP-ST8SiaIV-transgenic mice when compared with wild-type littermates, suggesting that long-term increase in PSA levels in regenerating nerves may favor selective motor target reinnervation. The combined negative and positive effects of a continuous polysialyltransferase overexpression observed during peripheral nerve regeneration suggest that an optimized time- and differentiation-dependent control of polysialyltransferase expression in Schwann cells may further improve recovery after peripheral nerves injury.

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Crossref · 10.1093/glycob/cwr113

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49 of 49 references verified0 citation errors · 0 not checkable

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  • The plasticity resulting from polysialic acid expression appears to be important for neuronal migration and for reorganization following injury.

    “The ' plasticity ' resulting from polysialic acid expression appears to be important for neuronal migration as well as reorganization following injury (546 -554).”

    From Biological roles of glycans (2017) · cites this paper as [552]

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Authors
Jungnickel, J., Eckhardt, M., Haastert-Talini, K., Claus, P., Bronzlik, P., Lipokatic-Takacs, E., Maier, H., Gieselmann, V., & Grothe, C.
Affiliations
  • Medizinische Hochschule Hannover (DE)
  • University of Bonn (DE)
Corresponding author
  • Eckhardt, M.
  • Grothe, C.
Venue
Glycobiology
Published
2011-08-12
Volume
22
Issue
1
Pages
107-115
ISSN
  • 0959-6658 (ISSN-L)
  • 1460-2423
OpenAlex
W2319268555
Cited by
18
References
49
Citations by year
2026: 1 · 2024: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 1
FWCI
0.53
Type
journal article
Language
en
Open access
closed
Locations
  • Glycobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
polysialic acid, Schwann cells, peripheral nerve regeneration, sciatic nerve crush injury, remyelination, CD56, transgenic mice, axon regeneration
MeSH terms
Animals, Axons, Cell Count, Gene Expression Regulation, Mice, Inbred C57BL, Mice, Transgenic, Nerve Regeneration, Promoter Regions, Genetic, Recombinant Proteins, Schwann Cells, Sciatic Nerve, Sialic Acids, Sialyltransferases, Gene Expression, Muscle, Skeletal, Mice, Peripheral Nerve Injuries

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