The trans-sialidase, the major Trypanosoma cruzi virulence factor: Three decades of studies

Freire-de-Lima, L; Fonseca, LM; Oeltmann, T; Mendonça-Previato, L; Previato, JO

doi:10.1093/glycob/cwv057

Cited by 80Trypanosoma species research and implicationsGlycosylation and Glycoproteins ResearchResearch on Leishmaniasis Studies

The trans-sialidase, the major Trypanosoma cruzi virulence factor: Three decades of studies

Freire-de-Lima, L, Fonseca, LM, Oeltmann, T, Mendonça-Previato, L, Previato, JO·2015·Glycobiology

DOI 10.1093/glycob/cwv057

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Abstract

Chagas' disease is a potentially life-threatening disease caused by the protozoan parasite Trypanosoma cruzi. Since the description of Chagas'disease in 1909 extensive research has identified important events in the disease in order to understand the biochemical mechanism that modulates T. cruzi-host cell interactions and the ability of the parasite to ensure its survival in the infected host. Exactly 30 years ago, we presented evidence for the first time of a trans-sialidase activity in T. cruzi (T. cruzi-TS). This enzyme transfers sialic acid from the host glycoconjugates to the terminal β-galactopyranosyl residues of mucin-like molecules on the parasite's cell surface. Thenceforth, many articles have provided convincing data showing that T. cruzi-TS is able to govern relevant mechanisms involved in the parasite's survival in the mammalian host, such as invasion, escape from the phagolysosomal vacuole, differentiation, down-modulation of host immune responses, among others. The aim of this review is to cover the history of the discovery of T. cruzi-TS, as well as some well-documented biological effects encompassed by this parasite's virulence factor, an enzyme with potential attributes to become a drug target against Chagas disease.

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“Since Sia plays essential functions on both inate and adaptative immunity (Amon et al. 2014; Chen et al. 2014) it is not surprising that TS proteins are able to dampen the host’s immune response.”
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Self-citation
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Biological roles of glycans
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635 · see citing works
“These mechanisms range from the simple acquisition of host sialoglycans (997) to the direct transfer of host sialic acids by trans-sialidases (998), to the highly efficient uptake of the small amounts of environmental free sialic acids (999) or even the direct utilization of trace amounts of CMP sialic acid present in…”
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Authors: Freire-de-Lima, L., Fonseca, L., Oeltmann, T., Mendonça-Previato, L., & Previato, J.
Affiliations: Vanderbilt University (US)
Venue: Glycobiology
Publisher: Oxford University Press (OUP)
Published: 2015-07-29
Volume: 25
Issue: 11
Pages: 1142-1149
ISSN: 0959-6658 (ISSN-L)
1460-2423
DOI: 10.1093/glycob/cwv057
OpenAlex: W1832557653
Cited by: 80
References: 97
Citations by year: 2026: 4 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 12 · 2019: 12 · 2018: 7 · 2017: 9 · 2016: 6 · 2015: 1
FWCI: 1.00
Type: journal article
Language: en
Open access: closed
Locations: Glycobiology (publishedVersion)
PubMed (publishedVersion)
Funders: Fundação de Apoio à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Topics: Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Keywords: trans-sialidase, Trypanosoma cruzi, Chagas disease, virulence factors, sialic acid transfer, host-parasite interactions, parasite invasion, parasite differentiation, immune evasion, therapeutic target
MeSH terms: Animals, Glycoproteins, Humans, Neuraminidase, Trypanosoma cruzi, Chagas Disease, Protozoan Proteins, Virulence Factors

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The trans-sialidase, the major Trypanosoma cruzi virulence factor: Three decades of studies

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