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SOX3 is an X-linked gene related to SRY
Abstract
The mammalian genome contains a family of genes that are related to SRY, the mammalian sex determining gene. The homology is restricted to the region of SRY that encodes a DNA binding motif of the HMG-box class. These genes have been named SOX genes (SRY-related HMG-box genes). We have cloned and characterised SOX3, a member of the human SOX gene family. SOX3 maps to the X chromosome in the region Xq26-27. A mentally retarded male patient with haemophilia B is deleted for both the Factor IX gene and SOX3. This suggests that SOX3 is not essential for testis formation. The phenotype of the patient and the expression of SOX3 gene in neuronal tissues raises the possibility that this gene is a candidate gene for Borjeson-Forssman-Lehmann, an X-linked mental retardation syndrome.
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Citations
Cited by
Four Evolutionary Strata on the Human X Chromosome
Lahn, B. T., & Page, D. C. (1999) · Science · doi:10.1126/science.286.5441.964 · Cited by 990
Vertebrate neurogenesis is counteracted by Sox1–3 activity
Bylund, M., Andersson, E., Novitch, B. G., & Muhr, J. (2003) · Nature Neuroscience · doi:10.1038/nn1131 · Cited by 825
A male-specific role for SOX9 in vertebrate sex determination
Kent, J., Wheatley, S. C., Andrews, J. E., Sinclair, A. H., & Koopman, P. (1996) · Development · doi:10.1242/dev.122.9.2813 · Cited by 710
SOX Genes: Architects of Development
Prior, H. M., & Walter, M. A. (1996) · Molecular Medicine · doi:10.1007/bf03401900 · Cited by 103
Metadata
- Authors
- Stevanovlć, M., Lovell-Badge, R., Collignon, J., & Goodfellow, P. N.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1993
- Volume
- 2
- Issue
- 12
- Pages
- 2013-2018
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2114336300
- Cited by
- 258
- References
- 0
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: SOX3 is an X-linked gene related to SRY. https://app.cochat.ai/papers/10.1093/hmg/2.12.2013
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- Stevanovlć, M., Lovell-Badge, R., Collignon, J., & Goodfellow, P. N. (1993). SOX3 is an X-linked gene related to SRY. Human Molecular Genetics. https://doi.org/10.1093/hmg/2.12.2013
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