The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A hypervariable segment in the human dopamine receptor D4 (DRD4) gene
Abstract
The human dopamine D4 receptor contains a novel polymorphism within the putative third cytoplasmic loop of the protein. The polymorphism is characterized by a varying number of direct imperfect 48-bp repeats in the gene. Pharmacological characterization has suggested that this receptor is the site through which the atypical neuroleptic clozapine exerts its antipsychotic action and that some polymorphic variants display different pharmacological properties. Further analysis of the repeat region using innovative technologies indicates that the alleles vary not only in the number of repeats (2-8 or 10 repeat units) but also in the sequence of the repeats and the order in which they appear. In 178 unrelated chromosomes we have identified 19 different repeats in 25 different haplotypes coding for 18 different predicted amino acid sequences, making this one of the most variable functional proteins currently described.
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Citations
Cites
Multiple dopamine D4 receptor variants in the human population
Tol, H. H. M. V., Wu, C. M., Guan, H.-C., Ohara, K., Bunzow, J. R., Civelli, O., Kennedy, J., Seeman, P., Niznik, H. B., & Jovanovic, V. (1992) · Nature · doi:10.1038/358149a0 · Cited by 955
Self-citation
Cited by
Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E. R., Nemanov, L., Katz, M., & Belmaker, R. H. (1996) · Nature Genetics · doi:10.1038/ng0196-78 · Cited by 1,475
Reward deficiency syndrome: genetic aspects of behavioral disorders
Comings, D. E., & Blum, K. (2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26022-6 · Cited by 621
Forbes, E. E., Brown, S. M., Kimak, M., Ferrell, R. E., Manuck, S. B., & Hariri, A. R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002086 · Cited by 408
Mechanisms of action of atypical antipsychotic drugs: a critical analysis
Kinon, B. J., & Lieberman, J. A. (1996) · Psychopharmacology · doi:10.1007/bf02245602 · Cited by 317
A meta-analysis of the association between DRD4 polymorphism and novelty seeking
Kluger, A. N., Siegfried, Z., & Ebstein, R. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001082 · Cited by 283
Metadata
- Authors
- Lichter, J. B., Barr, C. L., Kennedy, J. L., Van Tol, H. H. M., Kidd, K. K., & Livak, K. J.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1993
- Volume
- 2
- Issue
- 6
- Pages
- 767-773
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2113918287
- Cited by
- 524
- References
- 1
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lichter, J. B., Barr, C. L., Kennedy, J. L., Van Tol, H. H. M., Kidd, K. K., & Livak, K. J. (1993). A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Human Molecular Genetics. https://doi.org/10.1093/hmg/2.6.767
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