Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity

Forbes, E E; Brown, S M; Kimak, M; Ferrell, R E; Manuck, S B; Hariri, A R

doi:10.1038/sj.mp.4002086

Cited by 408Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSchizophrenia research and treatment

Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity

Open access

Forbes, E E, Brown, S M, Kimak, M, Ferrell, R E, Manuck, S B, Hariri, A R·2009·Molecular Psychiatry

DOI 10.1038/sj.mp.4002086PMC PMC2668513

Open this paper in CoChat — free account

Abstract

Individual differences in traits such as impulsivity involve high reward sensitivity and are associated with risk for substance use disorders. The ventral striatum (VS) has been widely implicated in reward processing, and individual differences in its function are linked to these disorders. Dopamine (DA) plays a critical role in reward processing and is a potent neuromodulator of VS reactivity. Moreover, altered DA signaling has been associated with normal and pathological reward-related behaviors. Functional polymorphisms in DA-related genes represent an important source of variability in DA function that may subsequently impact VS reactivity and associated reward-related behaviors. Using an imaging genetics approach, we examined the modulatory effects of common, putatively functional DA-related polymorphisms on reward-related VS reactivity associated with self-reported impulsivity. Genetic variants associated with relatively increased striatal DA release (DRD2 -141C deletion) and availability (DAT1 9-repeat), as well as diminished inhibitory postsynaptic DA effects (DRD2 -141C deletion and DRD4 7-repeat), predicted 9-12% of the interindividual variability in reward-related VS reactivity. In contrast, genetic variation directly affecting DA signaling only in the prefrontal cortex (COMT Val158Met) was not associated with variability in VS reactivity. Our results highlight an important role for genetic polymorphisms affecting striatal DA neurotransmission in mediating interindividual differences in reward-related VS reactivity. They further suggest that altered VS reactivity may represent a key neurobiological pathway through which these polymorphisms contribute to variability in behavioral impulsivity and related risk for substance use disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/sj.mp.4002086

Cites

83 of 83 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Experimental data suggest an association between risky and impulsive behavior, characteristic of ADHD, and dopamine release or dopamine-dependent BOLD response to rewards in the striatum.
“Additionally, experimental data suggest an association between risky and impulsive behavior, which is characteristic of ADHD,14–16 and dopamine release or dopamine-dependent BOLD response to rewards in the striatum.11,17–20”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [18]
The function of the reward circuitry can be modulated by functional genetic polymorphisms influencing dopamine neurotransmission in the striatum, directly (e.g. DAT1) or indirectly (e.g. NOS1).
“The function of the reward circuitry can be modulated by functional genetic polymorphisms influencing dopamine neurotransmission in the striatum, directly (e.g. the dopamine transporter gene [DAT1]) or indirectly (e.g. the nitric oxide synthase gene [NOS1]).18,22,26”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [18]
Some promising initial evidence has indicated that the DAT1 3′UTR polymorphism may be modulating the responsivity of the striatum during a response inhibition and a reward-processing paradigm.
“Some promising initial evidence has indicated that the DAT13′UTR polymorphism may be modulating the responsivity of the striatum during a response inhibition and a reward-processing paradigm (Durston et al, 2008; Forbes et al, 2009).”
From DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls (2010) · cites this paper as Forbes et al, 2009

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
Dopamine receptors: from structure to function
MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.189 · Cited by 3,633 · see citing works
Structured Clinical Interview for DSM-IV Axis I Disorders
Spitzer, R. L., First, M. B., & Gibbon, M. (1997) · Medical Entomology and Zoology · Cited by 3,582 · see citing works
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757 · see citing works
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647 · see citing works
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,374 · see citing works
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340 · see citing works
Self-citation
Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls.
Kirby, K. N., Petry, N. M., & Bickel, W. K. (1999) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.128.1.78 · Cited by 2,171 · see citing works
Parsing reward
Berridge, K. C., & Robinson, T. E. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00233-9 · Cited by 1,869 · see citing works
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788 · see citing works
Impulsivity and cigarette smoking: delay discounting in current, never, and ex-smokers
Bickel, W. K., Odum, A. L., & Madden, G. J. (1999) · Psychopharmacology · doi:10.1007/pl00005490 · Cited by 1,433 · see citing works
Violence and mental disorder: developments in risk assessment
(1994) · Choice Reviews Online · doi:10.5860/choice.32-0595 · Cited by 1,395 · see citing works
Dissociation of reward anticipation and outcome with event-related fMRI
Knutson, B., Fong, G. W., Adams, C. M., Varner, J. L., & Hommer, D. (2001) · Neuroreport · doi:10.1097/00001756-200112040-00016 · Cited by 1,300 · see citing works
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
Dalley, J. W., Fryer, T. D., Brichard, L., Robinson, E. S. J., Theobald, D. E. H., Lääne, K., Peña, Y., Murphy, E. R., Shah, Y., Probst, K., et al. (2007) · Science · doi:10.1126/science.1137073 · Cited by 1,188 · see citing works
Neural Predictors of Purchases
Knutson, B., Rick, S., Wimmer, G. E., Prelec, D., & Loewenstein, G. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.010 · Cited by 1,171 · see citing works
Tracking the Hemodynamic Responses to Reward and Punishment in the Striatum
Delgado, M. R., Nystrom, L. E., Fissell, C., Noll, D. C., & Fiez, J. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.6.3072 · Cited by 1,116 · see citing works
Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction
Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005) · Nature Neuroscience · doi:10.1038/nn1583 · Cited by 1,024 · see citing works
The role of impulsivity in the development of substance use and eating disorders
Dawe, S., & Loxton, N. J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.007 · Cited by 944 · see citing works
Impulsive and self-control choices in opioid-dependent patients and non-drug-using control patients: Drug and monetary rewards.
Madden, G. J., Petry, N. M., Badger, G. J., & Bickel, W. K. (1997) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.5.3.256 · Cited by 911 · see citing works
Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants
Asghari, V., Sanyal, S., Buchwaldt, S., Paterson, A., Jovanovic, V., & Van Tol, H. H. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031157.x · Cited by 858 · see citing works
Memory and Addiction
Kelley, A. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.016 · Cited by 773 · see citing works
Dopamine neurons and their role in reward mechanisms
Schultz, W. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80007-4 · Cited by 769 · see citing works
Functional magnetic resonance imaging of reward prediction
Knutson, B., & Cooper, J. C. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000173463.24758.f6 · Cited by 736 · see citing works
Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
Jönsson, E. G., Nöthen, M. M., Grünhage, F., Farde, L., Nakashima, Y., Propping, P., & Sedvall, G. C. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000532 · Cited by 721 · see citing works
Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR
Vandenbergh, D. J., Persico, A. M., Hawkins, A. L., Griffin, C. A., Li, X., Jabs, E. W., & Uhl, G. R. (1992) · Genomics · doi:10.1016/s0888-7543(05)80138-7 · Cited by 708 · see citing works
The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers
Pohjalainen, T., Rinne, J. O., Någren, K., Lehikoinen, P., Anttila, K., Syvälahti, E. K. G., & Hietala, J. A. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000350 · Cited by 672 · see citing works
Time and Decision: Economic and Psychological Perspectives on Intertemporal Choice
Güth, W. (2004) · The Journal of Socio-Economics · doi:10.1016/j.socec.2004.04.003 · Cited by 596 · see citing works
Dopamine receptors and brain function
Jaber, M., Robinson, S. W., Missale, C., & Caron, M. G. (1996) · Neuropharmacology · doi:10.1016/s0028-3908(96)00100-1 · Cited by 572 · see citing works
Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity
Hariri, A. R., Brown, S. M., Williamson, D. E., Flory, J. D., de Wit, H., & Manuck, S. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3446-06.2006 · Cited by 557 · see citing works
Self-citation
METHYLATION PHARMACOGENETICS: Catechol O-Methyltransferase, Thiopurine Methyltransferase, and Histamine N-Methyltransferase
Weinshilboum, R. M., Otterness, D. M., & Szumlanski, C. L. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.19 · Cited by 550 · see citing works
Pathological gambling severity is associated with impulsivity in a delay discounting procedure.
Alessi, S. M., & Petry, N. (2003) · Behavioural Processes · doi:10.1016/s0376-6357(03)00150-5 · Cited by 549 · see citing works
Genotype Influences In Vivo Dopamine Transporter Availability in Human Striatum
Heinz, A. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00099-8 · Cited by 538 · see citing works
A hypervariable segment in the human dopamine receptor D4 (DRD4) gene
Lichter, J. B., Barr, C. L., Kennedy, J. L., Tol, H. H. M. V., Kídd, K. K., & Livak, K. J. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.6.767 · Cited by 524 · see citing works
A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity
Manuck, S. B., Flory, J. D., Ferrell, R. E., Mann, J. J., & Muldoon, M. F. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00162-1 · Cited by 486 · see citing works
Self-citation
A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia
Arinami, T. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.4.577 · Cited by 455 · see citing works
Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
Meyer-Lindenberg, A., Kohn, P. D., Kolachana, B., Kippenhan, S., McInerney-Leo, A., Nussbaum, R., Weinberger, D. R., & Berman, K. F. (2005) · Nature Neuroscience · doi:10.1038/nn1438 · Cited by 428 · see citing works
Impulsiveness and aggression.
Barratt, E. S. (1994) · Cited by 428 · see citing works
The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus
Wang, E., Ding, Y.-C., Flodman, P. L., Kidd, J. R., Kídd, K. K., Grady, D. L., Ryder, O. A., Spence, M. A., Swanson, J. M., & Moyzis, R. K. (2004) · The American Journal of Human Genetics · doi:10.1086/420854 · Cited by 401 · see citing works
Genes and the parsing of cognitive processes
Goldberg, T. E., & Weinberger, D. R. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.05.011 · Cited by 356 · see citing works
Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR
Mill, J., Asherson, P., Browes, C., D'Souza, U., & Craig, I. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.b.10948 · Cited by 341 · see citing works
An fMRI study of reward-related probability learning
Delgado, M. R., Miller, M. M., Inati, S., & Phelps, E. A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.10.002 · Cited by 337 · see citing works
Imaging Genetics: Perspectives from Studies of Genetically Driven Variation in Serotonin Function and Corticolimbic Affective Processing
Hariri, A. R., Drabant, E. M., & Weinberger, D. R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.005 · Cited by 336 · see citing works
Self-citation
Catechol- O -Methyltransferase Genotype and Dopamine Regulation in the Human Brain
Akil, M., Kolachana, B. S., Rothmond, D. A., Hyde, T. M., Weinberger, D. R., & Kleinman, J. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02008.2003 · Cited by 325 · see citing works
Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans
Volkow, N. D., Fowler, J. S., & Wang, G.-J. (1999) · Journal of Psychopharmacology · doi:10.1177/026988119901300406 · Cited by 315 · see citing works
Relationships Among Ventral Striatal Dopamine Release, Cortisol Secretion, and Subjective Responses to Amphetamine
Oswald, L. M., Wong, D. F., McCaul, M., Zhou, Y., Kuwabara, H., Choi, L., Brasic, J., & Wand, G. S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300667 · Cited by 314 · see citing works
The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density
VanNess, S., Owens, M. J., & Kilts, C. D. (2005) · BMC Genetics · doi:10.1186/1471-2156-6-55 · Cited by 306 · see citing works
Dopamine and the structure of personality: Relation of agonist-induced dopamine activity to positive emotionality.
Depue, R. A., Luciana, M. M., Arbisi, P. A., Collins, P. F., & Leon, A. S. (1994) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.67.3.485 · Cited by 306 · see citing works
Time and Decision: Economic and Psychological Perspectives of Intertemporal Choice
Loewenstein, G. F., Read, D., & Baumeister, R. F. (2003) · Cited by 302 · see citing works
A neural correlate of reward-based behavioral learning in caudate nucleus: a functional magnetic resonance imaging study of a stochastic decision task
Haruno, M., Kuroda, T., Doya, K., Toyama, K., Kimura, M., Samejima, K., Imamizu, H., & Kawato, M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3417-03.2004 · Cited by 300 · see citing works
Imaging genomics
Hariri, A. R., & Weinberger, D. R. (2003) · British Medical Bulletin · doi:10.1093/bmb/65.1.259 · Cited by 299 · see citing works
Self-citation
Dopamine Modulates the Response of the Human Amygdala: A Study in Parkinson's Disease
Tessitore, A., Hariri, A. R., Fera, F., Smith, W. G., Chase, T. N., Hyde, T. M., Weinberger, D. R., & Mattay, V. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09099.2002 · Cited by 293 · see citing works
Self-citation
Aggression, Impulsivity, and Central Nervous System Serotonergic Responsivity in a Nonpatient Sample
Manuck, S. B., Flory, J. D., McCaffery, J. M., Matthews, K. A., Mann, J. J., & Muldoon, M. F. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00015-3 · Cited by 281 · see citing works
Self-citation
Individual differences in extraversion and dopamine genetics predict neural reward responses
Cohen, M. X., Young, J., Baek, J. M., Kessler, C., & Charan Ranganath, A. (2005) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2005.09.018 · Cited by 271 · see citing works
Limbic Corticostriatal Systems and Delayed Reinforcement
Cardinal, R. N., Winstanley, C. A., Robbins, T. W., & Everitt, B. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.004 · Cited by 266 · see citing works
Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene.
van Dyck, C. H., Malison, R. T., Jacobsen, L. K., Seibyl, J. P., Staley, J. K., Laruelle, M. A., Baldwin, R. M., Innis, R. B., & Gelernter, J. E. (2005) · PubMed · Cited by 258 · see citing works
Molecular neurobiology of dopaminergic receptors
Sibley, D. R., Monsma, F. J., & Shen, Y. (1993) · International review of neurobiology · doi:10.1016/s0074-7742(08)60573-5 · Cited by 255 · see citing works
Functional Magnetic Resonance Imaging of Brain Reward Circuitry in the Human
BREITER, H. C., & Rosen, B. R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09287.x · Cited by 231 · see citing works
The dopaminergic midbrain participates in human episodic memory formation: evidence from genetic imaging
Schott, B. H., Seidenbecher, C. I., Fenker, D. B., Lauer, C. J., Bunzeck, N., Bernstein, H.-G., Tischmeyer, W., Gundelfinger, E. D., Heinze, H.-J., & Düzel, E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3463-05.2006 · Cited by 214 · see citing works
The role of ventral frontostriatal circuitry in reward-based learning in humans.
Galvan, A., Hare, T. A., Davidson, M., Spicer, J., Glover, G., & Casey, B. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2431-05.2005 · Cited by 207 · see citing works
Liability to substance use disorders: 1. Common mechanisms and manifestations
Vanyukov, M. M., Tarter, R. E., Kirisci, L., Kirillova, G. P., Maher, B. S., & Clark, D. B. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.002 · Cited by 205 · see citing works
The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons
Michelhaugh, S. K., FISKERSTRAND, C. E., Lovejoy, E. A., Bannon, M. J., & Quinn, J. P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00647.x · Cited by 199 · see citing works
The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans
Martinez, D., Gelernter, J., Abi-Dargham, A., van Dyck, C., Kegeles, L., Innis, R., & Laruelle, M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00216-5 · Cited by 193 · see citing works
Dextroamphetamine modulates the response of the human amygdala
Hariri, A. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00373-1 · Cited by 185 · see citing works
Self-citation
The human dopamine transporter gene: gene organization, transcriptional regulation, and potential involvement in neuropsychiatric disorders
Bannon, M. J., Michelhaugh, S. K., Wang, J., & Sacchetti, P. (2001) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(01)00122-5 · Cited by 169 · see citing works
The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate
Cheon, K.-A. A., Ryu, Y. H., Kim, J.-W., & Cho, D.-Y. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.06.004 · Cited by 162 · see citing works
Aggression, Impulsivity, and Central Nervous System Serotonergic Responsivity in a Nonpatient Sample
Manuck, S. B., Flory, J. D., McCaffery, J. M., et al. (1998) · Neuropsychopharmacology · doi:10.1038/sj.npp.1395199 · Cited by 158 · see citing works
Self-citation
Genes Associated With Addiction: Alcoholism, Opiate, and Cocaine Addiction
Kreek, M. J., Nielsen, D. A., & LaForge, K. S. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:1:085 · Cited by 146 · see citing works
Temporal Difference Modeling of the Blood-Oxygen Level Dependent Response During Aversive Conditioning in Humans: Effects of Dopaminergic Modulation
Menon, M., Jensen, J., Vitcu, I., Graff‐Guerrero, A., Crawley, A. P., Smith, M. A., & Kapur, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.020 · Cited by 145 · see citing works
Ageing and the nigrostriatal dopaminergic system
Reeves, S., Bench, C. J., & Howard, R. (2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.606 · Cited by 135 · see citing works
Localization of dopamine receptor subtypes in corpus striatum and nucleus accumbens septi of rat brain: comparison of D1-, D2- and D4-like receptors
Tarazi, F. I., Campbell, A., Yeghiayan, S. K., & Baldessarini, R. J. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00386-2 · Cited by 122 · see citing works
Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine release
Oswald, L. M., Wong, D. F., Zhou, Y., Kumar, A., Brasic, J., Alexander, M., Ye, W., Kuwabara, H., Hilton, J., & Wand, G. S. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.01.055 · Cited by 108 · see citing works
Cellular and subcellular localization of the dopamine transporter in rat cortex
Sesack, S. R., Hawrylak, V. A., Guido, M. A., & Levey, A. I. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60720-6 · Cited by 101 · see citing works
Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1)
Mill, J. S., Asherson, P. J., Craig, I., & D’Souza, U. M. (2005) · BMC Genetics · doi:10.1186/1471-2156-6-3 · Cited by 91 · see citing works
Liability to substance use disorders: 2. A measurement approach
Vanyukov, M. M., Kirisci, L., Tarter, R. E., Simkevitz, H. F., Kirillova, G. P., Maher, B. S., & Clark, D. B. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.003 · Cited by 77 · see citing works
Dopamine and the structure of personality: Relation of agonist-induced dopamine activity to positive emotionality.
Depue, R. A., Luciana, M. M., Arbisi, P. A., Collins, P. F., & al, E. (1994) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.67.3.485 · Cited by 70 · see citing works
DRD2 Allele Frequencies and Linkage Disequilibria, Including the -141CIns/DelPromoter Polymorphism, in European-American, African-American, and Japanese Subjects
Gelernter, J. E., Kranzler, H. R., Cubells, J. F., Ichinose, H., & Nagatsu, T. (1998) · Genomics · doi:10.1006/geno.1998.5264 · Cited by 57 · see citing works
The dopamine D2 receptor 5'-flanking variant, -141C Ins/Del, is not associated with reduced dopamine D2 receptor density in vivo.
Pohjalainen, T., Någren, K., Syvälahti, E. K. G., & Hietala, J. A. (1999) · PubMed · Cited by 53 · see citing works
Net influx of plasma 6‐[18F]fluoro‐<scp>l</scp>‐DOPA (FDOPA) to the ventral striatum correlates with prefrontal processing of affective stimuli
Siessmeier, T., Kienast, T., Wrase, J., Larsen, J. L., Braus, D. F., Smolka, M. N., Buchholz, H. G., Schreckenberger, M., Rösch, F., Cumming, P., et al. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04903.x · Cited by 48 · see citing works
D2Autoreceptors Chronically Enhance Dopamine Neuron Pacemaker Activity
Hahn, J., Kullmann, P. H. M., Horn, J. P., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4976-05.2006 · Cited by 35 · see citing works
Expression of D2 receptor isoforms in cultured neurons reveals equipotent autoreceptor function
Jomphe, C., Tiberi, M., & Trudeau, L. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.11.010 · Cited by 31 · see citing works
An update on molecular genetic studies of human personality traits.
Ebstein, R. P., Zohar, A. H., Benjamin, J., & Belmaker, R. H. (2002) · PubMed · Cited by 24 · see citing works
Perspectives on Current Directions in the Neurobiology of Addiction Disorders Relevant to Genetic Risk Factors
Hurd, Y. L. (2006) · CNS Spectrums · doi:10.1017/s1092852900015005 · Cited by 13 · see citing works
Factor structure of the Barratt impulsiveness scale
Patton, J. H., Stanford, M. S., & Barratt, E. S. (1995) · Journal of Clinical Psychology · doi:10.1002/1097-4679(199511)51:6

Flagged first, then by citations

Sorted by citations

The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment
Ashok, A. H., Marques, T. R., Jauhar, S., Nour, M. M., Goodwin, G. M., Young, A. H., & Howes, O. D. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.16 · Cited by 546 · see citing works
Neurobiology of ADHD
Tripp, G., & Wickens, J. R. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.026 · Cited by 492 · see citing works
Ventral–striatal responsiveness during reward anticipation in ADHD and its relation to trait impulsivity in the healthy population: A meta-analytic review of the fMRI literature
Plichta, M. M., & Scheres, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.012 · Cited by 424 · see citing works
Test-retest reliability of evoked BOLD signals from a cognitive-emotive fMRI test battery.
Plichta, M. M., Schwarz, A. J., Grimm, O., Morgen, K., Mier, D., Haddad, L., Gerdes, A. B. M., Sauer, C., Tost, H., Esslinger, C., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.129 · Cited by 287 · see citing works
Dissecting impulsivity and its relationships to drug addictions
Jentsch, J. D., Ashenhurst, J. R., Cervantes, M. C., Groman, S. M., James, A. S., & Pennington, Z. T. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12388 · Cited by 281 · see citing works
The neurobiology of individual differences in complex behavioral traits
Hariri, A. R. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135335 · Cited by 273 · see citing works
Self-citation
Identifying Predictors, Moderators, and Mediators of Antidepressant Response in Major Depressive Disorder: Neuroimaging Approaches
Phillips, M. L., Chase, H. W., Sheline, Y. I., Etkin, A., Almeida, J. R. C., Deckersbach, T., & Trivedi, M. H. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010076 · Cited by 267 · see citing works
Mesolimbic dopamine release is linked to symptom severity in pathological gambling
Joutsa, J., Johansson, J., Niemelä, S., Ollikainen, A., Hirvonen, M. M., Piepponen, P., Arponen, E., Alho, H., Voon, V., Rinne, J. O., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.02.006 · Cited by 209 · see citing works
Reward-related brain function as a predictor of treatment response in adolescents with major depressive disorder
Forbes, E. E., Olino, T. M., Ryan, N. D., Birmaher, B., Axelson, D., Moyles, D. L., & Dahl, R. E. (2010) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.10.1.107 · Cited by 178 · see citing works
Self-citation
Genetic determinants of aggression and impulsivity in humans
Pavlov, K. A., Chistiakov, D. A., & Chekhonin, V. P. (2012) · Journal of Applied Genetics · doi:10.1007/s13353-011-0069-6 · Cited by 184 · see citing works
DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls
Paloyelis, Y., Asherson, P., Mehta, M. A., Faraone, S. V., & Kuntsi, J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.124 · Cited by 180 · see citing works
Reward-related brain function and sleep in pre/early pubertal and mid/late pubertal adolescents
Holm, S. M., Forbes, E. E., Ryan, N. D., Phillips, M. L., Tarr, J. A., & Dahl, R. E. (2009) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2009.04.001 · Cited by 174 · see citing works
Self-citation
Resilience and the brain: a key role for regulatory circuits linked to social stress and support
Holz, N. E., Tost, H., & Meyer-Lindenberg, A. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0551-9 · Cited by 162 · see citing works
Reward processing in unipolar and bipolar depression: A functional MRI study
Redlich, R., Dohm, K., Grotegerd, D., Opel, N., Zwitserlood, P., Heindel, W., Arolt, V., Kugel, H., & Dannlowski, U. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.110 · Cited by 164 · see citing works
Striatal dopamine mediates the interface between motivational and cognitive control in humans: evidence from genetic imaging.
Aarts, E., Roelofs, A., Franke, B., Rijpkema, M., Fernández, G., Helmich, R. C., & Cools, R. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.68 · Cited by 157 · see citing works
Effects of HTR1A C(−1019)G on Amygdala Reactivity and Trait Anxiety
Fakra, E., Hyde, L. W., Gorka, A., Fisher, P. M., Muñoz, K. E., Kimak, M., Halder, I., Ferrell, R. E., Manuck, S. B., & Hariri, A. R. (2009) · Archives of General Psychiatry · doi:10.1001/archpsyc.66.1.33 · Cited by 159 · see citing works
Self-citation
Striatal sensitivity to reward deliveries and omissions in substance dependent patients
Bjork, J. M., Smith, A. R., & Hommer, D. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.035 · Cited by 154 · see citing works
Context-dependent Dynamic Processes in Attention Deficit/Hyperactivity Disorder: Differentiating Common and Unique Effects of State Regulation Deficits and Delay Aversion
Sonuga-Barke, E. J. S., Wiersema, J. R., van der Meere, J. J., & Roeyers, H. (2010) · Neuropsychology Review · doi:10.1007/s11065-009-9115-0 · Cited by 142 · see citing works
Stress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology
Corral-Frías, N. S., Nikolova, Y. S., Michalski, L. J., Baranger, D. A. A., Hariri, A. R., & Bogdan, R. (2015) · Psychological Medicine · doi:10.1017/s0033291715000525 · Cited by 132 · see citing works
Ventral striatum reactivity to reward and recent life stress interact to predict positive affect
Nikolova, Y. S., Bogdan, R., Brigidi, B. D., & Hariri, A. R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.014 · Cited by 130 · see citing works
Self-citation
Response inhibition and its relation to multidimensional impulsivity
Wilbertz, T., Deserno, L., Horstmann, A., Neumann, J., Villringer, A., Heinze, H.-J., Boehler, C. N., & Schlagenhauf, F. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.09.021 · Cited by 128 · see citing works
The neural underpinnings of cognitive flexibility and their disruption in psychotic illness
Waltz, J. A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.005 · Cited by 122 · see citing works
DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience
Peciña, M., Mickey, B. J., Love, T., Wang, H., Langenecker, S. A., Hodgkinson, C., Shen, P.-H., Villafuerte, S., Hsu, D., Weisenbach, S. L., et al. (2013) · Cortex · doi:10.1016/j.cortex.2012.01.010 · Cited by 123 · see citing works
Sleep deprivation amplifies striatal activation to monetary reward
Mullin, B. C., Phillips, M. L., Siegle, G. J., Buysse, D. J., Forbes, E. E., & Franzen, P. L. (2013) · Psychological Medicine · doi:10.1017/s0033291712002875 · Cited by 120 · see citing works
Self-citation
Genetic markers of striatal dopamine predict individual differences in dysfunctional, but not functional impulsivity
Colzato, L. S., van den Wildenberg, W. P. M., Van der Does, A. J. W., & Hommel, B. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.07.050 · Cited by 117 · see citing works
Identifying differences between depressed adolescent suicide ideators and attempters
Auerbach, R. P., Millner, A. J., Stewart, J. G., & Esposito, E. C. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.031 · Cited by 117 · see citing works
Mood-congruent amygdala responses to subliminally presented facial expressions in major depression: associations with anhedonia
Stuhrmann, A., Dohm, K., Kugel, H., Zwanzger, P., Redlich, R., Grotegerd, D., Rauch, A. V., Arolt, V., Heindel, W., Suslow, T., et al. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120060 · Cited by 112 · see citing works
Approach/avoidance
McNaughton, N., DeYoung, C. G., & Corr, P. J. (2016) · Neuroimaging Personality, Social Cognition, and Character · doi:10.1016/b978-0-12-800935-2.00002-6 · Cited by 123 · see citing works
ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: Implications for smoking and nicotine dependence
Kollins, S. H., & Adcock, R. A. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.02.002 · Cited by 95 · see citing works
Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder
Paloyelis, Y., Mehta, M. A., Faraone, S. V., Asherson, P., & Kuntsi, J. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.05.006 · Cited by 94 · see citing works
Developmental imaging genetics: Linking dopamine function to adolescent behavior
Padmanabhan, A., & Luna, B. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2013.09.011 · Cited by 87 · see citing works
PER2 rs2304672 polymorphism moderates circadian-relevant reward circuitry activity in adolescents
Forbes, E. E., Dahl, R. E., Almeida, J. R. C., Ferrell, R. E., Nimgaonkar, V. L., Mansour, H., Sciarrillo, S. R., Holm, S. M., Rodriguez, E. E., & Phillips, M. L. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.012 · Cited by 83 · see citing works
Self-citation
Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood
Nemoda, Z., Szekely, A., & Sasvari-Szekely, M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.002 · Cited by 78 · see citing works
Association between reward‐related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype
Hahn, T., Heinzel, S., Dresler, T., Plichta, M. M., Renner, T. J., Markulin, F., Jakob, P. M., Lesch, K., & Fallgatter, A. J. (2011) · Human Brain Mapping · doi:10.1002/hbm.21127 · Cited by 78 · see citing works
Interactions between early parenting and a polymorphism of the child's dopamine transporter gene in predicting future child conduct disorder symptoms.
Lahey, B. B., Rathouz, P. J., Lee, S. S., Chronis-Tuscano, A., Pelham, W. E., Waldman, I. D., & Cook, E. H. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0021133 · Cited by 63 · see citing works
Isolating the delay component of impulsive choice in adolescent rats
McClure, J., Podos, J., & Richardson, H. N. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2014.00003 · Cited by 62 · see citing works
Be quick about it. Endogenous estradiol level, menstrual cycle phase and trait impulsiveness predict impulsive choice in the context of reward acquisition
Diekhof, E. K. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.001 · Cited by 62 · see citing works
The genetic basis of individual differences in reward processing and the link to addictive behavior and social cognition
Yacubian, J., & Büchel, C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.015 · Cited by 53 · see citing works
DNA methylation at the DAT promoter and risk for psychopathology: Intergenerational transmission between school-age youths and their parents in a community sample
Cimino, S., Cerniglia, L., Ballarotto, G., Marzilli, E., Pascale, E., D’Addario, C., Adriani, W., & Tambelli, R. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00303 · Cited by 48 · see citing works
Functional polymorphisms in dopaminergic genes modulate neurobehavioral and neurophysiological consequences of sleep deprivation
Holst, S. C., Müller, T., Valomon, A., Seebauer, B., Berger, W., & Landolt, H.-P. (2017) · Scientific Reports · doi:10.1038/srep45982 · Cited by 45 · see citing works
Interaction between COMT Val158Met polymorphism and childhood adversity affects reward processing in adulthood
Boecker-Schlier, R., Holz, N. E., Buchmann, A. F., Blomeyer, D., Plichta, M. M., Jennen-Steinmetz, C., Wolf, I., Baumeister, S., Treutlein, J., Rietschel, M., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.006 · Cited by 42 · see citing works
Genetic variation in <scp>GABRA</scp>2 moderates peer influence on externalizing behavior in adolescents
Villafuerte, S., Trucco, E. M., Heitzeg, M. M., Burmeister, M., & Zucker, R. A. (2014) · Brain and Behavior · doi:10.1002/brb3.291 · Cited by 22 · see citing works
Neuropsychological performance measures as intermediate phenotypes for attention-deficit/hyperactivity disorder: a multiple mediation analysis
Kamradt, J. M., Nigg, J. T., Friderici, K. H., & Nikolas, M. A. (2017) · Development and Psychopathology · doi:10.1017/s0954579416000195 · Cited by 19 · see citing works

The ventral striatum
Tremblay, L., Worbe, Y., & Hollerman, J. R. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374620-7.00003-0 · Cited by 29 · see citing works
Repression of Dlx1/2 Signaling by Nolz-1/Znf503 is Essential for Parcellation of the Striatal Complex into Dorsal and Ventral StriatumPreprint
Lu, K.-M., Chen, S.-Y., Ko, H.-A., Huang, T.-H., Hao, J. H.-J., Yan, Y., Chang, S. L., Evans, S. Μ., & Liu, F.-C. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/463398
Parcellation of the striatal complex into dorsal and ventral districts
Chen, S., Lu, K.-M., Ko, H.-A., Huang, T.-H., Hao, J. H.-J., Yan, Y., Chang, S. L., Evans, S. Μ., & Liu, F. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921007117 · Cited by 32 · see citing works
The Concept of the Ventral Striatum in Nonhuman Primates
HABER, S. N., & McFARLAND, N. R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09259.x · Cited by 253 · see citing works
Behavioural Effects of Manipulation of Basal Ganglia Neurotransmitters
Iversen, S. D. (1984) · Novartis Foundation symposium · doi:10.1002/9780470720882.ch10 · Cited by 31 · see citing works

Authors: Forbes, E. E., Brown, S. M., Kimak, M., Ferrell, R. E., Manuck, S. B., & Hariri, A. R.
Affiliations: University of Pittsburgh (US)
Corresponding author: Hariri, A R
ORCID: Forbes, E E
Brown, S M
Kimak, M
Manuck, S B
Hariri, A R
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2007-09-25
Volume: 14
Issue: 1
Pages: 60-70
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4002086
PMC: PMC2668513
OpenAlex: W1976177962
Cited by: 408
References: 83
Citations by year: 2026: 3 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 10 · 2021: 10 · 2020: 55 · 2019: 14 · 2018: 17 · 2017: 20 · 2016: 30 · 2015: 33 · 2014: 29 · 2013: 44 · 2012: 45
FWCI: 8.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institutes of Health
National Heart, Lung, and Blood Institute (P01HL040962)
National Institute of Mental Health (KO1 MH074769, K01MH072837, K01MH074769)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: impulsivity, ventral striatum, dopamine signaling, reward processing, genetic polymorphism, COMT Val158Met, striatal dopamine release, dopamine availability, individual differences, substance use disorders, imaging genetics
MeSH terms: Adult, Analysis of Variance, Basal Ganglia, Catechol O-Methyltransferase, Dopamine, Female, Gene Frequency, Genotype, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Magnetic Resonance Imaging, Male, Middle Aged, Synaptic Transmission, Oxygen, Reward, Genetic Variation, Case-Control Studies, Dopamine Plasma Membrane Transport Proteins, Receptors, Dopamine D3, Receptors, Dopamine D4, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks