Cited by 390Genetics and Neurodevelopmental DisordersRNA Research and SplicingRNA and protein synthesis mechanisms

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals

Eberhart, D.·1996·Human Molecular Genetics

Open this paper in CoChat — free account

Abstract

Fragile X syndrome is a frequent cause of mental retardation resulting from the absence of FMRP, the protein encoded by the FMR1 gene. FMRP is an RNA-binding protein of unknown function which is associated with ribosomes. To gain insight into FMRP function, we performed immunolocalization analysis of FMRP truncation and fusion constructs which revealed a nuclear localization signal (NLS) in the amino terminus of FMRP as well as a nuclear export signal (NES) encoded by exon 14. A 17 amino acid peptide containing the FMRP NES, which closely resembles the NES motifs recently described for HIV-1 Rev and PKI, is sufficient to direct nuclear export of a microinjected protein conjugate. Sucrose gradient analysis shows that FMRP ribosome association is RNA-dependent and FMRP is found in ribonucleoprotein (RNP) particles following EDTA treatment. These data are consistent with nascent FMRP entering the nucleus to assemble into mRNP particles prior to export back into the cytoplasm and suggests that fragile X syndrome may result from altered translation of transcripts which normally bind to FMRP.

Integrity signals

Registry

Crossref · 10.1093/hmg/5.8.1083

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90397-h · Cited by 3,481
Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox
Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Pieretti, M., Sutcliffe, J. S., Richards, S., Verkert, A. J. M. H., Holden, J. J. A., Fenwick, R. G., Warren, S. T., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90283-5 · Cited by 2,080
Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome
Oberlé, I., Rousseau, F., Heitz, D., Kretz, C., Devys, D., Hanauer, A., Boué, J., Bertheas, M. F., & Mandel, J. L. (1991) · Science · doi:10.1126/science.252.5009.1097 · Cited by 1,499
Identification of a signal for rapid export of proteins from the nucleus
Wen, W., Meinkotht, J. L., Tsien, R. Y., & Taylor, S. S. (1995) · Cell · doi:10.1016/0092-8674(95)90435-2 · Cited by 1,190
The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
Fischer, U., Huber, J., Boelens, W. C., Mattaj, I. W., & Lührmann, R. (1995) · Cell · doi:10.1016/0092-8674(95)90436-0 · Cited by 1,140
Nucleocytoplasmic Transport
Görlich, D., & Mattaj, I. W. (1996) · Science · doi:10.1126/science.271.5255.1513 · Cited by 1,081
The FMR–1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation
Devys, D., Lutz, Y., Rouyer, N., Bellocq, J., & Mandel, J. (1993) · Nature Genetics · doi:10.1038/ng0893-335 · Cited by 781
FMR1 Protein: Conserved RNP Family Domains and Selective RNA Binding
Ashley, C. T., Wilkinson, K. D., Reines, D., & Warren, S. T. (1993) · Science · doi:10.1126/science.7692601 · Cited by 752
DNA methylation represses FMR-1 transcription in fragile X syndrome
Sutcliffe, J. S., Nelson, D. L., Zhang, F., Pieretti, M., Caskey, C. T., Saxe, D., & Warren, S. T. (1992) · Human Molecular Genetics · doi:10.1093/hmg/1.6.397 · Cited by 680
The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein.
Siomi, H., Siomi, M. C., Nussbaum, R. L., & Dreyfuss, G. (1993) · Cell · doi:10.1016/0092-8674(93)90420-u · Cited by 641

Show all 53 references

Sorted by citations

Items 301–387 of 387

The potential role of ribonucleic acid methylation in the pathological mechanisms of fragile X syndrome
Chen, Y.-S., Dong, J., Tan, W., Liu, H., Zhang, S., Zou, J., Chen, Y., Bai, S.-Y., & Zeng, Y. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114586 · Cited by 4
FMR1 Protein Expression Correlates with Intelligence Quotient in Both Peripheral Blood Mononuclear Cells and Fibroblasts from Individuals with an FMR1 Mutation
Jiraanont, P., Zafarullah, M., Sulaiman, N., Espinal, G. M., Randol, J. L., Durbin-Johnson, B. P., Schneider, A., Hagerman, R. J., Hagerman, P. J., & Tassone, F. (2024) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2024.02.007 · Cited by 5
A Species-Correlated Transitional Residue D132 on Human FMRP Plays a Role in Nuclear Localization via an RNA-Dependent Interaction With PABP1
Zhou, Y., Long, J., Fu, J., Sun, W., Hu, F., Huang, H.-Y., Li, W., Gao, M., Shu, Y., Yi, Y., et al. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.01.028 · Cited by 4
Isolation and Identification of Gene-Specific MicroRNAs
Lin, S.-L., Chang, D. C., & Ying, S. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-083-0_21 · Cited by 4
Repeat-Associated MicroRNAs Trigger Fragile X Mental Retardation-Like Syndrome in Zebrafish~!2008-10-29~!2008-11-12~!2008-11-26~!
Chang, S.-J. E., Chang-Lin, S., Chang, D. C., Chang, C. P., Lin, S.-L., & Ying, S.-Y. (2008) · The Open Neuropsychopharmacology Journal · doi:10.2174/1876523800801010006 · Cited by 4
Fragile X mental retardation: Misregulation of protein synthesis in the developing brain?
Feng, Y. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10063 · Cited by 4
If genetic variation could talk: What genomic data may teach us about the importance of gene expression regulation in the genetics of autism
Yeh, E., & Weiss, L. A. (2016) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2016.10.007 · Cited by 4
Fragile X Syndrome Genetics
Nelson, D. L., Santoro, M. R., & Warren, S. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00002-0 · Cited by 3
Advances in Human Stem Cells and Genome Editing to Understand and Develop Treatment for Fragile X Syndrome
Zhao, X., & Bhattacharyya, A. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-45493-7_2 · Cited by 3
Ataxin-2 Dysregulation Triggers a Compensatory Fragile X Mental Retardation Protein Decrease in Drosophila C4da Neurons.
Cha, I. J., Lee, D., Park, S. S., Chung, C. G., Kim, S. Y., Jo, M. G., Kim, S. Y., Lee, B., Lee, Y., & Lee, S. B. (2020) · PubMed Central · doi:10.14348/molcells.2020.0158 · Cited by 3
Role of Repeat-Associated MicroRNA (ramRNA) in Fragile X Syndrome (FXS)
Lin, S.-L., & Ying, S. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8533-8_14 · Cited by 3
INVITED REVIEW - Inherited skeletal muscle disorders
N. G. Laing, F. L. M. (1999) · Annals of Human Biology · doi:10.1080/030144699282435 · Cited by 4
Fragile X-Linked Mental Retardation
Gantois, I., Kooy, R. F., & Oostra, B. A. (2006) · Wiley-VCH eBooks · doi:10.1002/3527600906.mcb.200300051 · Cited by 3
Fragile X Syndrome
Nelson, D. L. (1998) · Humana Press eBooks · doi:10.1007/978-1-59259-726-0_118 · Cited by 3
Comment on Herring et al. The Use of “Retardation” in FRAXA, FMRP, FMR1 and Other Designations. Cells 2022, 11, 1044
Bruford, E. A. (2022) · Cells · doi:10.3390/cells11121937 · Cited by 3
Fragile X—A Family of Disorders: Changing Phenotype and Molecular Genetics
Spector, E. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1688-4_19 · Cited by 2
Fragile X Syndrome: A Disorder of Synaptic Protein Synthesis Dynamics
Muddashetty, R. S., Nalavadi, V., & Bassell, G. J. (2012) · Journal of the Indian Institute of Science · Cited by 2
Recent Progress in Polymerase II-Mediated Intronic microRNA Expression Systems
Lin, S.-L., & Ying, S. (2009) · CRC Press eBooks · doi:10.1201/9781420008708.ch15 · Cited by 2
Fragile X
Crawford, D. C., & Howard‐Peebles, P. N. (2005) · Humana Press eBooks · doi:10.1385/1-59259-833-1:495 · Cited by 2
Zebrafish as a Model to study Human Disease: Functional Studies of the FXR Proteins
Padje, S. V. ‘. (2007) · Cited by 2
Fragile X mental retardation protein interacts with TDG
Chen, Y., Bardoni, B., Yu, M., Zhu, N., Wu, G., Mandel, J., & Shen, Y. (2000) · Chinese Science Bulletin · doi:10.1007/bf02887096 · Cited by 2
Expression of FMRP by Neurosphere Derived Cells Following Transplantation in the Fragile X Mouse Model
Pacey, L. K. K. (2013) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.s12-001 · Cited by 1
A missense variant in the KH0-domain of FMRP downregulates the protein in a patient with the clinical hallmarks of fragile X syndrome
D’Incal, C. P., Dierckx, B., Vingerhoets, C., van Haelst, M. M., Annear, D. J., Dijck, A. V., Bastini, L., Konings, A., Elinck, E., Mateiu, L. M., et al. (2025) · European Journal of Human Genetics · doi:10.1038/s41431-025-01967-x · Cited by 1
The enigma of nuclear FMRP: facts and myths
Khandjian, É. W., & Davidovic, L. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1756661 · Cited by 1
Chromosomal fragility and human genetic disorders
Baskaran, S., & Brahmachari, V. (2000) · Indian Journal of Clinical Biochemistry · doi:10.1007/bf02867554 · Cited by 1
New X-chromosomal interactors of dFMRP regulate axonal and synaptic morphology of brain neurons inDrosophila melanogaster
Miteva, D., Dimitrov, R., Kitanova, M., & Genova, G. (2014) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2014.937897 · Cited by 1
Unbalanced autosomal translocation identification of unbalanced 1; 9 autosomal translocation in a gir (bos indicus) bull calf
Padeeri, M., Reddy, C., Jain, N., Reddy, S. K., & Patel, R. (2011) · The Indian Cow/The Indian cow : the scientific and economic journal · Cited by 1
Targeting the GABAB Receptor in Fragile X Syndrome and Autism Spectrum Disorders
Healy, A. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-46044-4_13 · Cited by 1
Interactome of FMRP-N-tat therapeutic unveils key interactions for cellular function in Fragile X neurons
Leguay, K., Acevedo, M., Colic, E., Patel, P. U., Abadi, S. S. K., Chan, H. L., Sun, S., Lang-Ouellette, D., Chan, B., Zhan, X., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110341 · Cited by 2
Insights into the human Fragile X syndrome gene family using Drosophila melanogaster
Coffee, R. L. (2011) · Cited by 1
Études de l'expression des protéines fragile X related 1 (FXR1P) durant le développement des vertébrés
Huot, M. (2005) · Corpus Université Laval (Université Laval) · Cited by 1
The Fragile X Syndrome and the Fragile X Mutation
Hirst, M. C., & Fisch, G. S. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-353-8_14 · Cited by 1
Role of mGluR5 and FMRP in mouse primary somatosensory cortex
Wijetunge, L. S. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Molekulare Grundlagen neurologischer Trinukleotidblockexpansionssyndrome
Epplen, J. T., & Haupt, A. (2000) · Springer eBooks · doi:10.1007/978-3-642-57043-8_18
Fragile X Syndrome: From Pathophysiology to New Therapeutic Perspectives
D’Antoni, S., Spatuzza, M., Carmela, M., Aloisi, E., Musumeci, S. A., & Vincenza, M. (2012) · InTech eBooks · doi:10.5772/31387
Molecular Genetics and Prenatal Diagnosis
Phillips, J. A. (2009) · Wiley eBooks · doi:10.1002/9781444314342.ch11
Scanning the Human Genome for Novel Therapeutic Targets for Breast Cancer
Hannon, G. J. (2003) · doi:10.21236/ada417950
Chapter 5.3 Trinucleotide repeat disorders
Sandberg, G., Lindblad‐Toh, K., Oostra, B. A., Schalling, M., Crusio, W. E., Gerlai, R. T., & Huston, J. P. (1999) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(99)80060-1
Variabilidade do domínio KH-2 da proteína do retardo mental do X frágil (FMRP)
Velloso, F. J. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2013.tde-21032014-090729
Levantamento de proteínas candidatas a ativadoras do splicing do éxon 12 do gene FMR1
de Campos, M. V. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.41.2014.tde-26082014-152426
Post-transcriptional gene regulation in Drosophila : an investigation into the roles of RNA silencing and the DEAD-box helicase Belle
Natalin, P. (2009) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00008939
Expressão de isoformas da proteína do retardo mental do X frágil (FMRP) e sua regulação
Velloso, F. J. (2008) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.41.2008.tde-19032009-144613
Implicancias del gen FMR1 en la función ovárica
Ferder, I. C. (2014) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
Identification of an Antigen Related to the Sea Urchin RNA-Binding Protein LP54 in Mammalian Central Nervous System
Romancino, D. P., Guarneri, P., Cascio, C., Dalmazio, S., Guarneri, R., & Carlo, M. D. (2001) · Molecular Cell Biology Research Communications · doi:10.1006/mcbr.2001.0305
Investigação de elementos regulatórios do éxon 14 do gene Fmr1 e análise de expressão de suas isoformas
Corrêa, J. D. C. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2014.tde-01092014-085006
History Tends to Repeat: FMR-1 Silencing in Fragile X Syndrome
Haas, J. G. (2007) · Eukaryon
A Fragile Synapse: Changes at the Synapse in Fragile X Syndrome
Webber, A. J., & Christie, B. R. (2006) · Springer eBooks · doi:10.1007/978-0-387-32562-0_31
Molecular Characterisation and Assessment of Clinical Significance of Small Fragile X Alleles
Khaniani, M. S., & Derakhshan, S. M. (2013) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.5681/jarcm.2013.001
Social dysfunction and mental retardation
Pietropaolo, S., Sluyter, F., & Crusio, W. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.010
FRAGILE X SYNDROME IN NORTHERN FINLAND
Väisänen, M. (1999)
Variabilidade do domínio KH-2 da proteína do retardo mental do X frágil (FMRP)
Paulo, S. (2013)
Splicing Regulatory Elements and mRNA-abundance of dlg1 and capt, Genetically Interacting with dFMRP in Drosophila Brain
Petrova, M., Молле, Е., Nedelcheva‐Veleva, M., & Genova, G. (2014) · DOAJ (DOAJ: Directory of Open Access Journals)
Multipotent neural stem/progenitor cells as a model of genetic neuronal diseases
Kärkkäinen, V. (2012) · UEF eRepo (University of Eastern Finland)
Rôle de la protéine FMRP dans la formation et le dynamisme des granules à ARN
Mellaoui, S. (2012) · Corpus Université Laval (Université Laval)
Dysregulated ERK signal pathway and immune profiles in Fragile X Syndrome
Weng, N. (2012) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Funktionelle Charakterisierung von FMRP, dem Krankheitsgenprodukt des Fragilen X-Syndroms
München, L.-M.-U. (2004)
FMRP and the Pathophysiology of Fragile X Syndrome
Barnes, S. A., Thomson, S. R., Kind, P. C., & Osterweil, E. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00008-x
Virus-mediated Delivery of the Fmr1 Gene as a Tool for the Treatment of Fragile X Syndrome
Moghaddam, S. G. (2016) · TSpace (University of Toronto)
Nuclear binding and translation regulation by FMRP through novel associated protein and putative RNA helicase MOV10
Kim, M. (2014) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Molecular mechanisms involved in altered differentiation of neural progenitors in Fragile X Syndrome
Achuta, V. S. (2018) · Työväentutkimus Vuosikirja
Molecular Correlates of Fragile X Syndrome and FXTAS
Tassone, F., & Hagerman, P. J. (2007) · Springer eBooks · doi:10.1007/3-540-33336-3_2
Cooperative Regulation of Translational Repression by FMRP and the miRNA Pathway
Kaul, N. (2018) · Digital Commons - DU (University of Denver)
Vignettes: Models in Absentia
Denman, R. B. (2011) · Results and problems in cell differentiation · doi:10.1007/978-3-642-21649-7_19
Do topo para a base: aconselhamento genético em famílias a partir da síndrome de tremor/ataxia associada ao X frágil (FXTAS)
Ribeiro, M. D. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.41.2018.tde-09052018-085516
The expression pattern of FMRP and MAP-1b during tooth development
Kim, H. J. (2017) · The Korean Journal of Oral Anatomy · doi:10.35607/kjoa.38.1.201712.004
A drosophila model of cellular and molecular mechanisms of fragile x syndrome.
Pan, L. (2007)
Functional characterization of the TTF complex and its role in neurodevelopmental disorders
Brosi, C. (2018) · Online Publication Service of Würzburg University (Würzburg University) · doi:10.25972/opus-15778
What Can the Study of Behavioral Phenotypes Teach Us About the Pathway from Genes to Behavior?
Flint, J. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-353-8_4
Faculty Opinions recommendation of Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies.
Davidovic, L. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718169565.793487178
Fmr1 exon 14 skipping in late embryonic development of the rat forebrain
Corrêa-Velloso, J. C., Linardi, A., Glaser, T., Velloso, F. J., Rivas, M. P., Leite, R. E. P., Grinberg, L. T., Ulrich, H., Akins, M. R., Chiavegatto, S., et al. (2022) · BMC Neuroscience · doi:10.1186/s12868-022-00711-1 · Cited by 1
Analysis of ribosomes from WT and FMR1 KO human embryonic stem cellsPreprint
Kharbanda, T., D’Souza, M. N., Palakodeti, D., Muddashetty, R. S., & Vinothkumar, K. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.18.624098
Dysregulation of an H3K79me2-dependent epigenetic barrier impairs neural progenitor cell proliferation and differentiation in Fragile X syndromePreprint
Dionne, O., Gaudreau, G.-L., Bergis, C., Avino, M., Sabatié, S., Corbin, F., & Laurent, B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.31.673358
Toward peptide-based protein replacement in fragile X syndrome: Evaluating the N-tat strategy
Kent, O. A. (2025) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2025.100244
Oxytocin and Vasopressin in Autism and Genetic Syndromes
Levin‐Decanini, T., Francis, S. M., Sagar, A., Liu, W., Carter, C. S., & Jacob, S. (2015) · Contemporary clinical neuroscience · doi:10.1007/978-1-4939-2190-4_14
Additional file 1 of Fmr1 exon 14 skipping in late embryonic development of the rat forebrain
Corrêa-Velloso, J. C., Linardi, A., Glaser, T., Velloso, F. J., Rivas, M. P., Leite, R. E. P., Grinberg, L. T., Ulrich, H., Akins, M. R., Chiavegatto, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19947736
RNA-Binding Proteins: Modulators of Canonical Wnt Signaling Pathway
Czap, M. S., Singh, V., & Spiegelman, V. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010205
Involvement of mGluR5/Homer crosstalk disruption in the pathophysiology of Fragile X Syndrome
Aloisi, E. (2015) · theses.fr (ABES) · doi:10.70675/e628d840zb6adz4e63z9d1fz71559b23fe24
Anomalies sensorielles visuelles du Syndrome de l'X fragile, contribution rétinienne au phénotype de dys-sensibilité
Felgerolle, C. (2019) · theses.fr (ABES) · doi:10.70675/fbd5cf69zed5az4a57zbfdez48e26a937a72
Functional characterization of new genes and molecular pathways implicated in developmental brain disorders
Drozd, M. M. (2020) · theses.fr (ABES) · doi:10.70675/bd6e393fzd4c4z4de0z8980z0e6ffa109757
Pathophysiological consequences of a Fragile X missense mutation
Garcia, M. P. (2020) · theses.fr (ABES) · doi:10.70675/b8e86263z5926z4a83zbaf6z0f61bf2d15f9
Pathophysiology of the FMRP-R138Q Fragile X Syndrome missense mutation in mice
Chato-Astrain, I. (2025) · theses.fr (ABES) · doi:10.70675/ce8d1ccfz4554z4c55z8782z624e392f72a1
Variants leading to ELAVL2 haploinsufficiency cause a neurodevelopmental disorder with prominent cognitive, behavioral, and neurological features
Boon, M., Mulligan, M. R., Verseput, J. J. A., Šakić, B., Schreurs, P., Coll-Tané, M., Accogli, A., Alderman, E., Athey, T. B. T., Boerkoel, C. F., et al. (2026) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2026.07.007
Hippocampal Astrocytes Impact Postnatal Development of Inhibitory Connections, Parvalbumin Levels, Social, and Spatial Navigation Behaviors in a Mouse Model of Fragile X Syndrome
Wagner, V. A., Maples, S., Thapa, R., Wimberly, J., Pettijohn, E., Varallo, A., Rais, M., Sutley-Koury, S. N., Hickmott, P., & Ethell, I. M. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70541
Nova Mediates Experience Dependent Processing of Orb2A mRNA
Gill, J. S. (2013) · Cited by 1
Inhibitory neurotransmission in the Fmr1 knockout mouse model of Fragile X Syndrome : region- and circuit-specific deficits
Paluszkiewicz, S. M. (2011) · DigitalGeorgetown (Georgetown University Library)
Molekulargenetische Grundlagen des fra(X)-Syndroms—Diagnostik und therapeutische Hilfen
Steinbach, P. J. (2000) · Springer eBooks · doi:10.1007/978-3-642-57043-8_17
Genetyczne przyczyny upośledzenia umysłowego, z którymi neurolog może spotkać się w codziennej praktyce
Jastrzębski, K., Kacperska, M. J., Pietras, T., & Radek, M. (2013) · DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Eberhart, D.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Eberhart, D.
Venue: Human Molecular Genetics
Publisher: Oxford University Press (OUP)
Published: 1996-08-01
Volume: 5
Issue: 8
Pages: 1083-1091
ISSN: 0964-6906 (ISSN-L)
1460-2083
DOI: 10.1093/hmg/5.8.1083
OpenAlex: W2106239245
Cited by: 390
References: 53
Citations by year: 2026: 3 · 2025: 7 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 11 · 2018: 13 · 2017: 10 · 2016: 11 · 2015: 13 · 2014: 17 · 2013: 21 · 2012: 21
FWCI: 9.58
Type: journal article
Language: en
Open access: closed
Locations: Human Molecular Genetics (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 20521)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: fragile X syndrome, FMRP, FMR1 gene, nuclear localization signal, nuclear export signal, ribonucleoprotein, RNA-binding proteins, ribosome association, exon 14, protein localization, translational regulation
MeSH terms: Amino Acid Sequence, Animals, Biological Transport, Active, Cell Nucleus, Exons, Fragile X Syndrome, Humans, Models, Biological, Molecular Sequence Data, Nerve Tissue Proteins, Recombinant Fusion Proteins, Ribonucleoproteins, Ribosomes, Transfection, RNA-Binding Proteins, COS Cells, Protein Sorting Signals, Fragile X Messenger Ribonucleoprotein 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks