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Cited by 260

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

HIP-I: A huntingtin interacting protein isolated by the yeast two-hybrid system

Wanker, E. E., Rovira, C., Scherzinger, E., Hasenbank, R., Walter, S., Tait, D., Colicelli, J., Lehrach, H.·1997·Human Molecular Genetics
DOI 10.1093/hmg/6.3.487
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Abstract

We report the discovery of the huntingtin interacting protein I (HIP-I) which binds specifically to the N-terminus of human huntingtin, both in the two-hybrid screen and in in vitro binding experiments. For the interaction in vivo, a protein region downstream of the polyglutamine stretch in huntingtin is essential. The HIP1 cDNA isolated by the two-hybrid screen encodes a 55 kDa fragment of a novel protein. Using an affinity-purified polyclonal antibody raised against recombinant HIP-I, a protein of 116 kDa was detected in brain extracts by Western blot analysis. The predicted amino acid sequence of the HIP-I fragment exhibits significant similarity to cytoskeleton proteins, suggesting that HIP-I and huntingtin play a functional role in the cell filament networks. The HIP1 gene is ubiquitously expressed in different brain regions at low level. HIP-I is enriched in human brain but can also be detected in other human tissues as well as in mouse brain. HIP-I and huntingtin behave almost identically during subcellular fractionation and both proteins are enriched in the membrane containing fractions.

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Crossref · 10.1093/hmg/6.3.487

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1 of 1 references verified0 citation errors · 0 not checkable

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  • A potential cargo for HIP1 is huntingtin.

    “A potential cargo for HIP1 is huntingtin, which interacts with the N-terminal segment of HIP1 (Wanker et al., 1997) and has been localized to clathrin-coated structures and endosomes (Velier et al., 1998).”

    From Disabled‐2 exhibits the properties of a cargo‐selective endocytic clathrin adaptor (2002) · cites this paper as Wanker et al., 1997

  • Huntingtin interacts with the N-terminal segment of HIP1.

    “A potential cargo for HIP1 is huntingtin, which interacts with the N-terminal segment of HIP1 (Wanker et al., 1997) and has been localized to clathrin-coated structures and endosomes (Velier et al., 1998).”

    From Disabled‐2 exhibits the properties of a cargo‐selective endocytic clathrin adaptor (2002) · cites this paper as Wanker et al., 1997

Citations

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Research works printed but not linked: 38

  1. Zuhlke, 1993, Human Molecular Genetics, 2, 2063, 10.1093/hmg/2.12.2063 · DOI
  2. Barron, 1993, Journal of Medical Genetics, 30, 1003, 10.1136/jmg.30.12.1003 · DOI
  3. Mangiarini, 1996, Cell, 87, 493, 10.1016/S0092-8674(00)81369-0 · DOI · Paper page
  4. Trottier, 1995, Nature genetics, 10, 104, 10.1038/ng0595-104 · DOI
  5. Schilling, 1995, Human Molecular Genetics, 4, 1365, 10.1093/hmg/4.8.1365 · DOI
  6. Barinaga, 1996, Science, 271, 1233, 10.1126/science.271.5253.1233 · DOI
  7. Li, 1995, Nature; Physical Science (London), 378, 398, 10.1038/378398a0 · DOI
  8. Burke, 1996, Nature medicine, 2, 347, 10.1038/nm0396-347 · DOI
  9. Graham, 1996, Journal of Biological Chemistry, 271, 19385, 10.1074/jbc.271.32.19385 · DOI
  10. 1995, 14, 1065
  11. 1995, 14, 1075
  12. Gutekunst, 1995, PNAS, 92, 8710, 10.1073/pnas.92.19.8710 · DOI
  13. Hoogeveen, 1993, Human Molecular Genetics, 2, 2069, 10.1093/hmg/2.12.2069 · DOI
  14. 1996, Human Molecular Genetics, 5, 1093, 10.1093/hmg/5.8.1093 · DOI
  15. Gerber, 1994, Science, 263, 808, 10.1126/science.8303297 · DOI
  16. Fields, 1994, Trends in genetics : TIG, 10, 286, 10.1016/0168-9525(90)90012-U · DOI
  17. Hoffmann, 1985, Journal of Biological Chemistry, 260, 11831, 10.1016/S0021-9258(17)39106-8 · DOI
  18. Han, 1995, Molecular and Cellular Biology, 15, 1318, 10.1128/MCB.15.3.1318 · DOI
  19. Andrade, 1995, Nature genetics, 11, 115, 10.1038/ng1095-115 · DOI
  20. Brent, 1985, Cell, 43, 729, 10.1016/0092-8674(85)90246-6 · DOI
  21. Kawaguchi, 1994, Nature genetics, 8, 221, 10.1038/ng1194-221 · DOI
  22. 1996, MOL CELL NEUROSCL, 7, 1, 10.1006/mcne.1996.0001 · DOI
  23. Breeden, 1985, Cold Spring Harbor Symposia on Quantitative Biology, 50, 643, 10.1101/SQB.1985.050.01.078 · DOI
  24. Kozak, 1987, Nucleic Acids Research, 15, 8125, 10.1093/nar/15.20.8125 · DOI
  25. Altschul, 1990, Journal of molecular biology, 215, 403, 10.1006/jmbi.1990.9999 · DOI · Paper page
  26. Wilson, 1994, Nature; Physical Science (London), 368, 32, 10.1038/368032a0 · DOI
  27. Holtzman, 1993, The Journal of Cell Biology, 122, 635, 10.1083/jcb.122.3.635 · DOI
  28. Rees, 1990, Nature; Physical Science (London), 347, 685, 10.1038/347685a0 · DOI
  29. Landschulz, 1988, Science, 240, 1759, 10.1126/science.3289117 · DOI · Paper page
  30. 1988, 67, 31
  31. Le Grice, 1990, FEBS Journal, 187, 307, 10.1111/j.1432-1033.1990.tb15306.x · DOI
  32. 1962, J ANAL, 96, 79
  33. Hesketh, 1994, Molecular biology reports, 19, 233, 10.1007/BF00986965 · DOI
  34. Luna, 1992, Science, 258, 955, 10.1126/science.1439807 · DOI
  35. Hollenberg, 1995, Molecular and Cellular Biology, 15, 3813, 10.1128/MCB.15.7.3813 · DOI
  36. Schiestl, 1989, Current genetics, 16, 339, 10.1007/BF00340712 · DOI
  37. 1994, 17, 257
  38. Towbin, 1979, PNAS, 76, 4350, 10.1073/pnas.76.9.4350 · DOI

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Metadata

Authors
Wanker, E. E., Rovira, C., Scherzinger, E., Hasenbank, R., Walter, S., Tait, D., Colicelli, J., & Lehrach, H.
Venue
Human Molecular Genetics
Publisher
Oxford University Press (OUP)
Published
1997-03-01
Volume
6
Issue
3
Pages
487-495
ISSN
  • 0964-6906
  • 1460-2083
DOI
10.1093/hmg/6.3.487
Cited by
260
References
1
Language
en

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