The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Nonsense-mediated mRNA decayin health and disease
Abstract
All eukaryotes possess the ability to detect and degrade transcripts harboring premature signals for the termination of translation. Despite the ubiquitous nature of nonsense-mediated mRNA decay (NMD) and its demonstrated role in the modulation of phenotypes resulting from selected nonsense alleles, very little is known regarding its basic mechanism or the selective pressure for complete evolutionary conservation of this function. This review will present the current models of NMD that have been generated during the study of model organisms and mammalian cells. The physiological burden of nonsense transcripts and the emerging view that NMD plays a broad and critical role in the regulation of gene expression will also be discussed. Such issues are relevant to the proposal that pharmacological manipulation of NMD will find therapeutic application.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition
Kronenberg, M. (1986) · Annual Review of Immunology · doi:10.1146/annurev.immunol.4.1.529 · Cited by 765
When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.
Maquat, L. E. (1995) · Europe PMC (PubMed Central) · Cited by 513
Leeds, P., Peltz, S. W., Jacobson, A., & Culbertson, M. R. (1991) · Genes & Development · doi:10.1101/gad.5.12a.2303 · Cited by 502
Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations
Howard, M., Frizzell, R. A., & Bedwell, D. M. (1996) · Nature Medicine · doi:10.1038/nm0496-467 · Cited by 493
mRNA surveillance by the Caenorhabditis elegans smg genes.
Pulak, R., & Anderson, P. (1993) · Genes & Development · doi:10.1101/gad.7.10.1885 · Cited by 475
Interference of nonsense mutations with eukaryotic messenger RNA stability.
Losson, R., & Lacroute, F. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.10.5134 · Cited by 473
The Skipping of Constitutive Exons in Vivo Induced by Nonsense Mutations
Dietz, H. C., Valle, D., Francomano, C. A., Kendzior, R. J., Pyeritz, R. E., & Cutting, G. A. (1993) · Science · doi:10.1126/science.8430317 · Cited by 417
Self-citationPremature translational termination triggers mRNA decapping
Muhlrad, D., & Parker, R. (1994) · Nature · doi:10.1038/370578a0 · Cited by 415
Binary specification of nonsense codons by splicing and cytoplasmic translation
Thermann, R., Neu‐Yilik, G., Deters, A., Frede, U., Wehr, K., Hagemeier, C., Hentze, M. W., & Kulozik, A. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3484 · Cited by 406
Culbertson, M. R. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(98)01658-8 · Cited by 396
Cited by
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics
Maquat, L. E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1310 · Cited by 1,214
Brunkow, M. E., Gardner, J. C., Van Ness, J., Paeper, B. W., Kovacevich, B. R., Proll, S., Skonier, J. E., Zhao, L., Sabo, P. J., Fu, Y.-H., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/318811 · Cited by 1,011
Sosnay, P. R., Siklosi, K. R., Van Goor, F., Kaniecki, K., Yu, H., Sharma, N., Ramalho, A. S., Amaral, M. D., Dorfman, R., Zielenski, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2745 · Cited by 630
Yamashita, A., Ohnishi, T., Kashima, I., Taya, Y., & Ohno, S. (2001) · Genes & Development · doi:10.1101/gad.913001 · Cited by 420
Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease
Khajavi, M., Inoue, K., & Lupski, J. R. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201649 · Cited by 417
Metadata
- Authors
- Frischmeyer, P. A.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-09-01
- Volume
- 8
- Issue
- 10
- Pages
- 1893-1900
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2109276727
- Cited by
- 992
- References
- 74
- FWCI
- 15.66
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nonsense-mediated mRNA decayin health and disease. https://app.cochat.ai/papers/10.1093/hmg/8.10.1893
- The paper
- Frischmeyer, P. A. (1999). Nonsense-mediated mRNA decayin health and disease. Human Molecular Genetics. https://doi.org/10.1093/hmg/8.10.1893
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
