Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

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A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance

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Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans

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The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions

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AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs

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The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense‐mediated mRNA decay

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A Perfect Message

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Evidence for a Pioneer Round of mRNA Translation

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Human Upf Proteins Target an mRNA for Nonsense-Mediated Decay When Bound Downstream of a Termination Codon

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The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans

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A nuclear cap binding protein complex involved in pre-mRNA splicing

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When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

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Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures

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The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.Preprint

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SR Splicing Factors Serve as Adapter Proteins for TAP-Dependent mRNA Export

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mRNA surveillance by the Caenorhabditis elegans smg genes.Preprint

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The yeast exosome and human PM-Scl are related complexes of 3' right-arrow 5' exonucleasesPreprint

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The Mex67p‐mediated nuclear mRNA export pathway is conserved from yeast to human

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Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

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A quantitative analysis of intron effects on mammalian gene expression

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Premature translational termination triggers mRNA decapping

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Binary specification of nonsense codons by splicing and cytoplasmic translation

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The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrn1 in distinct cytoplasmic foci

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Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly

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Gene Structure Prediction and Alternative Splicing Analysis Using Genomically Aligned ESTsPreprint

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A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing

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Splicing Factors SRp20 and 9G8 Promote the Nucleocytoplasmic Export of mRNA

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Nonsense-Mediated mRNA Decay in Mammalian Cells Involves Decapping, Deadenylating, and Exonucleolytic Activities

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Coupled Transcription and Translation Within Nuclei of Mammalian Cells

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Communication of the Position of Exon-Exon Junctions to the mRNA Surveillance Machinery by the Protein RNPS1

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Splicing is required for rapid and efficient mRNA export in metazoans

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Identification of a Human Decapping Complex Associated with hUpf Proteins in Nonsense-Mediated Decay

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Yra1p, a conserved nuclear RNA‐binding protein, interacts directly with Mex67p and is required for mRNA export

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Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection

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The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAsPreprint

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A Mouse Cytoplasmic Exoribonuclease (mXRN1p) with Preference for G4 Tetraplex Substrates

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The hDcp2 protein is a mammalian mRNA decapping enzyme

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Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon–exon junctionsPreprint

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Gene Products That Promote mRNA Turnover in Saccharomyces cerevisiae

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Pre-mRNA Splicing Imprints mRNA in the Nucleus with a Novel RNA-Binding Protein that Persists in the Cytoplasm

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A Regulatory Mechanism That Detects Premature Nonsense Codons in T-cell Receptor Transcripts in Vivo Is Reversed by Protein Synthesis Inhibitors in Vitro

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The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates

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Quality Control of mRNA Function

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Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability

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Intron function in the nonsense-mediated decay of β-globin mRNA: Indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

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Nonsense‐mediated mRNA decay in Drosophila:at the intersection of the yeast and mammalian pathways

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Role of the Nonsense-Mediated Decay Factor hUpf3 in the Splicing-Dependent Exon-Exon Junction Complex

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At Least One Intron Is Required for the Nonsense-Mediated Decay of Triosephosphate Isomerase mRNA: a Possible Link between Nuclear Splicing and Cytoplasmic Translation

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Y14 and hUpf3b Form an NMD-Activating Complex

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A splicing‐dependent regulatory mechanism that detects translation signals.

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The Role of the Cap Structure in RNA Processing and Nuclear Export

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REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus

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Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing‐dependent exon–exon junction complex

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Aberrant mRNAs with extended 3′ UTRs are substrates for rapid degradation by mRNA surveillance

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mRNA surveillance: the perfect persist

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A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export.

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The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila

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Poly(A) Tail Shortening by a Mammalian Poly(A)-specific 3′-Exoribonuclease

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SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast

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An NMD Pathway in Yeast Involving Accelerated Deadenylation and Exosome-Mediated 3′→5′ Degradation

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A coactivator of pre-mRNA splicingPreprint

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Selenium Deficiency Reduces the Abundance of mRNA for Se-Dependent Glutathione Peroxidase 1 by a UGA-Dependent Mechanism Likely To Be Nonsense Codon-Mediated Decay of Cytoplasmic mRNA

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A Pre-mRNA-Binding Protein Accompanies the RNA from the Gene through the Nuclear Pores and into Polysomes

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Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport

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The role of Upf proteins in modulating the translation read‐through of nonsense‐containing transcripts

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Translation Is Required to Remove Y14 from mRNAs in the Cytoplasm

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Exon junction complexes mediate the enhancing effect of splicing on mRNA expression

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A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus.

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Mechanisms of mRNA Surveillance in Eukaryotes

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Nonsense Surveillance in Lymphocytes?

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Exportin‐5‐mediated nuclear export of eukaryotic elongation factor 1A and tRNA

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The protein Mago provides a link between splicing and mRNA localization

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Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

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A Human Homolog of Yeast Est1 Associates with Telomerase and Uncaps Chromosome Ends When Overexpressed

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REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export

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Evidence that translation reinitiation abrogates nonsense‐mediated mRNA decay in mammalian cells

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The RNA Binding Protein Pub1 Modulates the Stability of Transcripts Containing Upstream Open Reading Frames

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A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsensecontaining mRNAs in mammalian cells

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Cap‐dependent deadenylation of mRNA

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Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay

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Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

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The Y14 protein communicates to the cytoplasm the position of exon–exon junctions

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The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesisPreprint

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Novel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes

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A novel mode of RBD-protein recognition in the Y14–Mago complex

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