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Pharmacokinetic and Pharmacodynamic Effects of a γ‐Secretase Modulator, PF ‐06648671, on CSF Amyloid‐β Peptides in Randomized Phase I Studies

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Hereditary and Sporadic Forms of Aβ-Cerebrovascular Amyloidosis and Relevant Transgenic Mouse Models

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Evidence from Solid-State NMR for Nonhelical Conformations in the Transmembrane Domain of the Amyloid Precursor Protein

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The Amyloid Cascade Hypothesis

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Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer’s Agents by Structure-Based Design

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Molecular Determinants and Thermodynamics of the Amyloid Precursor Protein Transmembrane Domain Implicated in Alzheimer's Disease

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Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives

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Homozygous carriers of APP A713T mutation in an autosomal dominant Alzheimer disease family

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Effects of Intrinsic and Extrinsic Factors on Aggregation of Physiologically Important Intrinsically Disordered Proteins

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APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer’s disease mutations

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Immunodominant epitope and properties of pyroglutamate-modified Aβ-specific antibodies produced in rabbits

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Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations

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γ-Secretase: Substrates and Inhibitors

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An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo

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Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4

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Molecular and clinical insights into protein misfolding and associated amyloidosis

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Lessons from genome‐wide association studies findings in Alzheimer's disease

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Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer’s agents: Structure-activity relationship study of Arg-mimetic region

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Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex

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Disordered proteins in dementia

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Histological and immunohistochemical characteristics of cerebral amyloid angiopathy in elderly dogs

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Fractal analysis of amyloid plaques in Alzheimer's disease patients and mouse models

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Using γ-Secretase Inhibitors to Distinguish the Generation of the Aβ Peptides Terminating at Val-40 and Ala-42

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Unusual Aß amyloid deposition in Alzheimer's disease due to an APP T7141 mutation at the γ42-secretase site

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Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575

Effects of γ‐secretase cleavage‐region mutations on APP processing and Aβ formation: interpretation with sequential cleavage and α‐helical model

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P‐012: Sequence around the ζ‐cleavage site plays a key role in γ‐secretase‐mediated app processing and aβ formation

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