A Cell Biological Perspective on Alzheimer's Disease

Annaert, Wim; De Strooper, Bart

doi:10.1146/annurev.cellbio.18.020402.142302

Cited by 182

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

A Cell Biological Perspective on Alzheimer's Disease

Annaert, Wim, De Strooper, Bart·2002·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev.cellbio.18.020402.142302

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Abstract

▪ Abstract The amyloid precursor protein and the proteases cleaving this protein are important players in the pathogenesis of Alzheimer's disease via the generation of the amyloid peptide. Physiologically, the amyloid precursor protein is implied in axonal vesicular trafficking and the proteases are implicated in developmentally important signaling pathways, most significantly those involving regulated intramembrane proteolysis or RIP. We discuss the cell biology behind the amyloid and tangle hypothesis for Alzheimer's disease, drawing on the many links to the fields of cell biology and developmental biology that have been established in the recent years.

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From GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-Peptide (2006) · cites this paper as Annaert and de Strooper, 2002

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Authors: Annaert, W., & De Strooper, B.
Affiliations: Neuronal Cell Biology Laboratory, Flanders Interuniversity Institute for Biotechnology (VIB) and Catholic University of Leuven, Center for Human Genetics Herestraat 49, 3000 Leuven Belgium;
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2002-11
Volume: 18
Issue: 1
Pages: 25-51
ISSN: 1081-0706
1530-8995
DOI: 10.1146/annurev.cellbio.18.020402.142302
Cited by: 182
References: 13
Language: en

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A Cell Biological Perspective on Alzheimer's Disease

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