The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Phenotypic differences in genetically identical organisms: the epigenetic perspective
Abstract
Human monozygotic twins and other genetically identical organisms are almost always strikingly similar in appearance, yet they are often discordant for important phenotypes including complex diseases. Such variation among organisms with virtually identical chromosomal DNA sequences has largely been attributed to the effects of environment. Environmental factors can have a strong effect on some phenotypes, but evidence from both animal and human experiments suggests that the impact of environment has been overstated and that our views on the causes of phenotypic differences in genetically identical organisms require revision. New theoretical and experimental opportunities arise if epigenetic factors are considered as part of the molecular control of phenotype. Epigenetic mechanisms may explain paradoxical findings in twin and inbred animal studies when phenotypic differences occur in the absence of observable environmental differences and also when environmental differences do not significantly increase the degree of phenotypic variation.
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Citations
Cites
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Epigenetic inheritance at the agouti locus in the mouse
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Classical twin studies and beyond
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BackgroundInfluential
Cited by
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307
Gene-environment interplay and psychopathology: multiple varieties but real effects
Rutter, M., Moffitt, T. E., & Caspi, A. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01557.x · Cited by 1,058
Epigenetics and aging: the targets and the marks
Fraga, M. F., & Esteller, M. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.05.008 · Cited by 690
Metadata
- Authors
- Wong, A. H. C., Gottesman, I. I., & Petronis, A.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-04-15
- Volume
- 14
- Issue
- suppl_1
- Pages
- R11-R18
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2124600498
- Cited by
- 431
- References
- 9
- FWCI
- 10.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wong, A. H. C., Gottesman, I. I., & Petronis, A. (2005). Phenotypic differences in genetically identical organisms: the epigenetic perspective. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddi116
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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