The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Foxl2 is required for commitment to ovary differentiation
Open accessAbstract
Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.
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Citations
Cites
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene
Foster, J. W., Dominguez-Steglich, M. A., Guioli, S., Kwok, C., Weller, P. A., Stevanović, M., Weissenbach, J., Mansour, S., Young, I. D., Goodfellow, P. N., et al. (1994) · Nature · doi:10.1038/372525a0 · Cited by 1,612
Germline stem cells and follicular renewal in the postnatal mammalian ovary
Johnson, J., Canning, J., Kaneko, T., Pru, J. K., & Tilly, J. L. (2004) · Nature · doi:10.1038/nature02316 · Cited by 1,278
Development of Follicles in the Mammalian Ovary
Hirshfield, A. N. (1991) · International Review of Cytology · doi:10.1016/s0074-7696(08)61524-7 · Cited by 1,277
Female development in mammals is regulated by Wnt-4 signalling
Vainio, S., Heikkilä, M., Kispert, A., Chin, N., & McMahon, A. P. (1999) · Nature · doi:10.1038/17068 · Cited by 1,271
Crisponi, L., Deiana, M., Loi, A., Chiappe, F., Uda, M., Amati, P., Bisceglia, L., Zelante, L., Nagaraja, R., Porcu, S., et al. (2001) · Nature Genetics · doi:10.1038/84781 · Cited by 990
Self-citationSchmidt, D., Ovitt, C. E., Anlag, K., Fehsenfeld, S., Gredsted, L., Treier, A.-C., & Treier, M. (2004) · Development · doi:10.1242/dev.00969 · Cited by 762
Peters, A. H. F. M., Plug, A. W., van Vugt, M. J., & de Boer, P. (1997) · Chromosome Research · doi:10.1023/a:1018445520117 · Cited by 728
Sox9 induces testis development in XX transgenic mice
Vidal, V. P. I., Chaboissier, M.-C., de Rooij, D. G., & Schedl, A. (2001) · Nature Genetics · doi:10.1038/90046 · Cited by 679
Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β
Couse, J. F., Hewitt, S. C., Bunch, D. O., Sar, M., Walker, V. R., Davis, B. J., & Korach, K. S. (1999) · Science · doi:10.1126/science.286.5448.2328 · Cited by 595
Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development
Uda, M., Ottolenghi, C., Crisponi, L., Garcia, J. E., Deiana, M., Kimber, W., Forabosco, A., Cao, A., Schlessinger, D., & Pilia, G. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh124 · Cited by 583
Self-citation
Cited by
Sex determination and SRY: down to a wink and a nudge?
Sekido, R., & Lovell-Badge, R. (2009) · Trends in Genetics · doi:10.1016/j.tig.2008.10.008 · Cited by 316
A post-translational modification code for transcription factors: sorting through a sea of signals
Benayoun, B. A., & Veitia, R. A. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.02.003 · Cited by 121
Impaired Fertility and FSH Synthesis in Gonadotrope-Specific Foxl2 Knockout Mice
Tran, S., Zhou, X., Lafleur, C., Calderon, M. J., Ellsworth, B. S., Kimmins, S., Boehm, U., Treier, M., Boerboom, D., & Bernard, D. J. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1286 · Cited by 74
Metadata
- Authors
- Ottolenghi, C., Omari, S., Garcia-Ortiz, J. E., Uda, M., Crisponi, L., Forabosco, A., Pilia, G., & Schlessinger, D.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-06-08
- Volume
- 14
- Issue
- 14
- Pages
- 2053-2062
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2125522014
- Cited by
- 355
- References
- 36
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Foxl2 is required for commitment to ovary differentiation. https://app.cochat.ai/papers/10.1093/hmg/ddi210
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- Ottolenghi, C., Omari, S., Garcia-Ortiz, J. E., Uda, M., Crisponi, L., Forabosco, A., Pilia, G., & Schlessinger, D. (2005). Foxl2 is required for commitment to ovary differentiation. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddi210
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
