The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cancer genetics of epigenetic genes
Abstract
The cancer epigenome is characterised by specific DNA methylation and chromatin modification patterns. The proteins that mediate these changes are encoded by the epigenetics genes here defined as: DNA methyltransferases (DNMT), methyl-CpG-binding domain (MBD) proteins, histone acetyltransferases (HAT), histone deacetylases (HDAC), histone methyltransferases (HMT) and histone demethylases. We review the evidence that these genes can be targeted by mutations and expression changes in human cancers.
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Cites
The polycomb group protein EZH2 is involved in progression of prostate cancer
Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717
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Induction of tumors in mice by genomic hypomethylation
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“Another study showed that mice carrying a hypomorphic and a null allele of Dnmt1 developed aggressive T cell lymphomas (79).”
BackgroundSchultz, D. C., Ayyanathan, K., Negorev, D., Maul, G. G., & Rauscher, F. J. (2002) · Genes & Development · doi:10.1101/gad.973302 · Cited by 1,313
JmjC-domain-containing proteins and histone demethylation
Klose, R. J., Kallin, E. M., & Zhang, Y. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1945 · Cited by 1,290
Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
Petrif, F., Giles, R. H., Dauwerse, H. G., Saris, J. J., Hennekam, R. C. M., Masuno, M., Tommerup, N., van Ommen, G.-J. B., Goodman, R. H., Peters, D. J. M., et al. (1995) · Nature · doi:10.1038/376348a0 · Cited by 1,217
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
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Risk of tumorigenesis in overgrowth syndromes: a comprehensive review
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“Because of reporter bias, the estimate of an increased risk of cancer for patients of Sotos syndrome is uncertain but has been reported to be in the range of 2–3% (144,145).”
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“Targeted inactivating mutations of PRDM2 in mice are associated with development of large B-cell lymphoma and a range of unusual tumors (168).”
Background
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EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Epigenetic Determinants of Cancer
Baylin, S. B., & Jones, P. A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019505 · Cited by 1,226
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Cheng, Y., He, C., Wang, M., Ma, X., Mo, F., Yang, S., Han, J., & Wei, X. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0095-0 · Cited by 1,097
Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions
Crider, K. S., Bailey, L. B., & Berry, R. J. (2011) · Nutrients · doi:10.3390/nu3030370 · Cited by 608
Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
Timp, W., & Feinberg, A. P. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3486 · Cited by 586
Metadata
- Authors
- Miremadi, A., Oestergaard, M. Z., Pharoah, P. D. P., & Caldas, C.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04-15
- Volume
- 16
- Issue
- R1
- Pages
- R28-R49
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2128814015
- Cited by
- 249
- References
- 10
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- closed
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