Cited by 1,290Epigenetics and DNA MethylationGenomics and Chromatin DynamicsCancer-related gene regulation

JmjC-domain-containing proteins and histone demethylation

Klose, Robert J., Kallin, Eric M., Zhang, Yi·2006·Nature Reviews Genetics

Abstract

Histone methylation has important roles in regulating gene expression and forms part of the epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove methyl marks from histones have recently been identified, revealing a new level of plasticity within this epigenetic modification system. Here we analyse the evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins and discuss their cellular functions in relation to their potential enzymatic activities.

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Crossref · 10.1038/nrg1945

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  • Epigenetic therapies targeting MYC through transcriptional repression are only transiently effective as cancer cells evolve multiple adaptive responses to retain MYC expression.

    “whilst several epigenetic therapies targeting the prototypical oncogene MYC through transcriptional repression generated much excitement, it is now clear that this is only transiently effective as cancer cells evolve multiple adaptive responses to retain MYC expression 184-186 .”
  • Preclinical modelling of resistance mechanisms has shown that resistance to epigenetic therapies largely emerges through cellular reprogramming and transcriptional plasticity.

    “Preclinical modelling of resistance mechanisms has shown that resistance to these therapies largely emerge through cellular reprogramming and transcriptional plasticity 184-186 .”

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Authors
Klose, R. J., Kallin, E. M., & Zhang, Y.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
Zhang, Yi
Venue
Nature Reviews Genetics
Published
2006-09
Volume
7
Issue
9
Pages
715-727
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W1982409009
Cited by
1,290
References
106
Citations by year
2026: 40 · 2025: 47 · 2024: 53 · 2023: 69 · 2022: 57 · 2021: 83 · 2020: 64 · 2019: 73 · 2018: 84 · 2017: 58 · 2016: 66 · 2015: 83 · 2014: 80 · 2013: 57 · 2012: 68
FWCI
4.01
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Keywords
Jumonji C domain, histone demethylation, histone methylation, chromatin modification, epigenetic inheritance, protein evolution, gene expression regulation
MeSH terms
Histone Methyltransferases, Amino Acid Sequence, Animals, Gene Expression Regulation, Histones, Humans, Molecular Sequence Data, Nuclear Proteins, Oxidoreductases, N-Demethylating, Phylogeny, Histone-Lysine N-Methyltransferase, Protein Methyltransferases, Transcription, Genetic, Sequence Alignment, Protein Structure, Tertiary, Amino Acid Motifs, Epigenesis, Genetic

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