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The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling
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“a number of HSP proteins are inhibitors of BMP signalling in model organisms or in cultured cells”
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“upregulated BMP signalling has been proposed as a unifying pathogenic mechanism for HSP [34–36].”
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Cites
Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts
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NIPA1 gene mutations cause autosomal dominant hereditary spastic paraplegia (SPG6)
Rainier, S., Chai, J.-H., Tokarz, D., Nicholls, R. D., & Fink, J. K. (2003) · The American Journal of Human Genetics · doi:10.1086/378817 · Cited by 207
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Cited by
Magnesium in man: implications for health and disease
de Baaij, J. H. F., Hoenderop, J. G. J., & Bindels, R. J. M. (2015) · Physiological Reviews · doi:10.1152/physrev.00012.2014 · Cited by 1,726
Harbour, M. E., Breusegem, S. Y. A., Antrobus, R., Freeman, C., Reid, E., & Seaman, M. N. J. (2010) · Journal of Cell Science · doi:10.1242/jcs.071472 · Cited by 246
Self-citationCafferkey, M., Ahn, J. W., Flinter, F., & Ogilvie, C. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36554 · Cited by 92
Silva, A. I., Haddon, J. E., Ahmed Syed, Y., Trent, S., Lin, T.-C. E., Patel, Y., Carter, J., Haan, N., Honey, R. C., Humby, T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11119-7 · Cited by 71
Freeman, C., Seaman, M. N. J., & Reid, E. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.10.011 · Cited by 50
Self-citation
Metadata
- Authors
- Tsang, H. T. H., Edwards, T. L., Wang, X., Connell, J. W., Davies, R. J., Durrington, H. J., O'Kane, C. J., Luzio, J. P., & Reid, E.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-07-20
- Volume
- 18
- Issue
- 20
- Pages
- 3805-3821
- ISSN
- 1460-2083
- 0964-6906
- Cited by
- 131
- References
- 2
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.