The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta
Abstract
The first definitive cell fate decision in development occurs at the blastocyst stage with establishment of the trophoblast and embryonic cell lineages. In the mouse, lineage commitment is achieved by epigenetic regulation of a critical gatekeeper gene, the transcription factor Elf5, that reinforces placental cell fate and is necessary for trophoblast stem (TS) cell self-renewal. In humans, however, the epigenetic lineage boundary seems to be less stringent since human embryonic stem (ES) cells, unlike their murine counterparts, harbour some potential to differentiate into trophoblast derivatives. Here, we show that ELF5 is expressed in the human placenta in villous cytotrophoblast cells but not in post-mitotic syncytiotrophoblast and invasive extravillous cytotrophoblast cells. ELF5 establishes a circuit of mutually interacting transcription factors with CDX2 and EOMES, and the highly proliferative ELF5(+)/CDX2(+) double-positive subset of cytotrophoblast cells demarcates a putative TS cell compartment in the early human placenta. In contrast to placental trophoblast, however, ELF5 is hypermethylated and largely repressed in human ES cells and derived trophoblast cell lines, as well as in induced pluripotent stem cells and murine epiblast stem cells. Thus, these cells exhibit an embryonic lineage-specific epigenetic signature and do not undergo an epigenetic reprogramming to reflect the trophoblast lineage at key loci such as ELF5. Our identification of the trophoblast-specific transcriptional circuit established by ELF5 will be instrumental to derive human TS cell lines that truly reflect early placental trophoblast and that will be most beneficial to gain insights into the aetiology of common pregnancy complications, including intra-uterine growth restriction and pre-eclampsia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The first trimester is a critical period for placental development, for expression of markers of trophoblast stemness decline rapidly after 12 weeks of gestation (252), suggesting loss of proliferative potential.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [252]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Embryonic Stem Cell Lines Derived from Human Blastocysts
Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947
Human DNA methylomes at base resolution show widespread epigenomic differences
Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Niwa, H., Miyazaki, J., & Smith, A. G. (2000) · Nature Genetics · doi:10.1038/74199 · Cited by 3,904
New cell lines from mouse epiblast share defining features with human embryonic stem cells
Tesar, P. J., Chenoweth, J. G., Brook, F. A., Davies, T. J., Evans, E. P., Mack, D. L., Gardner, R. L., & McKay, R. D. G. (2007) · Nature · doi:10.1038/nature05972 · Cited by 2,187
Self-citationDerivation of pluripotent epiblast stem cells from mammalian embryos
Brons, I. G. M., Smithers, L. E., Trotter, M. W. B., Rugg‐Gunn, P. J., Sun, B., Lopes, S. M. C. D. S., Howlett, S., Clarkson, A., Ährlund‐Richter, L., Pedersen, R. A., et al. (2007) · Nature · doi:10.1038/nature05950 · Cited by 2,007
Promotion of Trophoblast Stem Cell Proliferation by FGF4
Tanaka, S., Kunath, T., Hadjantonakis, A., Nagy, A., & Rossant, J. (1998) · Science · doi:10.1126/science.282.5396.2072 · Cited by 1,370
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA
Sharif, J., Muto, M., Takebayashi, S., Suetake, I., Iwamatsu, A., Endo, T. A., Shinga, J., Mizutani-Koseki, Y., Toyoda, T., Okamura, K., et al. (2007) · Nature · doi:10.1038/nature06397 · Cited by 1,360
The Uterine Spiral Arteries In Human Pregnancy: Facts and Controversies
Pijnenborg, R., Vercruysse, L., & HANSSENS, M. C. A. J. A. (2006) · Placenta · doi:10.1016/j.placenta.2005.12.006 · Cited by 1,229
Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation
Niwa, H., Toyooka, Y., Shimosato, D., Strumpf, D., Takahashi, K., Yagi, R., & Rossant, J. (2005) · Cell · doi:10.1016/j.cell.2005.08.040 · Cited by 1,192
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–181 of 181
Schmidt, J. K., Keding, L. T., Block, L. N., Wiepz, G. J., Koenig, M. R., Meyer, M. G., Dusek, B. M., Kroner, K. M., Bertogliat, M. J., Kallio, A. R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76313-w · Cited by 28
Placentation in the Human and Higher Primates
Burton, G. J., & Jauniaux, E. R. M. (2021) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-030-77360-1_11 · Cited by 30
Self-citationUnique features and emerging in vitro models of human placental development
Shibata, S., Kobayashi, E. H., Kobayashi, N., Oike, A., Okae, H., & Arima, T. (2020) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12347 · Cited by 27
Roles of CDX2 and EOMES in human induced trophoblast progenitor cells
Chen, Y., Wang, K., Gong, Y., Khoo, S. K., & Leach, R. E. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.12.135 · Cited by 26
Giakoumopoulos, M., & Golos, T. G. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0433 · Cited by 25
Wu, B., Cao, X., Liang, X., Zhang, X., Zhang, W., Sun, G., & Wang, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117510 · Cited by 24
Characterization of invasive trophoblasts generated from human embryonic stem cells
Udayashankar, R., Baker, D., Tuckerman, E. M., Laird, S. M., Li, T. C., & Moore, H. D. M. (2010) · Human Reproduction · doi:10.1093/humrep/deq350 · Cited by 24
Self-citationActivin/Nodal Signaling Switches the Terminal Fate of Human Embryonic Stem Cell-derived Trophoblasts
Sarkar, P., Randall, S. M., Collier, T. S., Nero, A., Russell, T. A., Muddiman, D. C., & Rao, B. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.620641 · Cited by 23
Review: Trophoblast differentiation from human embryonic stem cells
Golos, T. G., Giakoumopoulos, M., & Gerami‐Naini, B. (2012) · Placenta · doi:10.1016/j.placenta.2012.11.019 · Cited by 22
Cellular Dynamics of Mouse Trophoblast Stem Cells: Identification of a Persistent Stem Cell Type1
Motomura, K., Oikawa, M., Hirose, M., Honda, A., Togayachi, S., Miyoshi, H., Ohinata, Y., Sugimoto, M., Abe, K., Inoue, K., et al. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.115.137125 · Cited by 21
Chromosomal instability in human trophoblast stem cells and placentas
Wang, D., Cearlock, A., Lane, K., Xu, C., Jan, I., McCartney, S. A., Glass, I. A., McCoy, R. C., & Yang, M. (2025) · Nature Communications · doi:10.1038/s41467-025-59245-9 · Cited by 19
Lodewijk, G. A., Kozuki, S., Han, C. J., Topacio, B. R., Lee, S., Nixon, L., Zargari, A., Knight, G. T., Ashton, R. S., Qi, L. S., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.02.015 · Cited by 19
Human Trophoblast Progenitors: Where Do They Reside?
Genbačev, O., Lamb, J. D., Prakobphol, A., Donne, M. L., McMaster, M., & Fisher, S. J. (2013) · Seminars in Reproductive Medicine · doi:10.1055/s-0032-1331798 · Cited by 19
Hemberger, M. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.663930 · Cited by 18
Self-citationAccessing the human trophoblast stem cell state from pluripotent and somatic cells
Karvas, R. M., David, L., & Theunissen, T. W. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04549-y · Cited by 16
Genomic imprinting in human placentation
Kobayashi, E. H., Shibata, S., Oike, A., Kobayashi, N., Hamada, H., Okae, H., & Arima, T. (2022) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12490 · Cited by 16
Chen, A. C. H., Lee, Y. L., Ruan, H., Huang, W. M., Fong, S. W., Tian, S. I. P., Lee, K. C., Wu, G. M., Tan, Y., Wong, T. C. H., et al. (2023) · Advanced Science · doi:10.1002/advs.202204797 · Cited by 16
Nonvillous Parts and Trophoblast Invasion
Benirschke, K., Burton, G. J., & Baergen, R. N. (2012) · Springer eBooks · doi:10.1007/978-3-642-23941-0_9 · Cited by 16
Self-citationHuman Trophoblast in Trisomy 21: A Model for Cell–Cell Fusion Dynamic Investigation
Malassiné, A., Pidoux, G., Gerbaud, P., Frendo, J., & Evain‐Brion, D. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-0782-5_4 · Cited by 16
Weber, M., Göhner, C., Martín, S. S., Vattai, A., Hutter, S., Párraga, M., Jeschke, U., Schleußner, E., Markert, U. R., & Fitzgerald, J. S. (2016) · Cell Adhesion & Migration · doi:10.1080/19336918.2016.1142035 · Cited by 16
Flannery, C. A., Fleming, A. G., Choe, G. H., Naqvi, H., Zhang, M., Sharma, A. R., & Taylor, H. S. (2016) · Endocrinology · doi:10.1210/en.2016-1233 · Cited by 16
Dynamic changes in gene expression and signalling during trophoblast development in the horse
Read, J. E., Cabrera-Sharp, V., Offord, V., Mirczuk, S. M., Allen, S., Fowkes, R. C., & de Mestre, A. M. (2018) · Reproduction · doi:10.1530/rep-18-0270 · Cited by 16
Cellular systems biology identifies dynamic trophoblast populations in early human placentas
Wong, F., Lin, C., & Cox, B. (2019) · Placenta · doi:10.1016/j.placenta.2018.12.012 · Cited by 15
Development of the Human Placental Villus
Aplin, J., Lewis, R. M., & Jones, C. J. P. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99857-x · Cited by 15
Bianco, K., Gormley, M. J., Farrell, J., Zhou, Y., Oliverio, O., Tilden, H., McMaster, M., & Fisher, S. J. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4862 · Cited by 16
ELF5 in epithelial ovarian carcinoma tissues and biological behavior in ovarian carcinoma cells
Yan, H., Qiu, L., Xie, X., He, Y., Liu, Y., Lin, X., & Huang, H. (2017) · Oncology Reports · doi:10.3892/or.2017.5418 · Cited by 13
Unravelling the biological secrets of microchimerism by single-cell analysis
Ståhlberg, A., Heliebi, A. E., Sedlmayr, P., & Kroneis, T. (2017) · Briefings in Functional Genomics · doi:10.1093/bfgp/elx027 · Cited by 13
Chenthuran, T., Harendra, G. G., Jayasekara, R. W., & Dissanayake, V. H. W. (2014) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12362 · Cited by 11
The Chromosome 19 miRNA cluster guards trophoblasts against overacting innate immunity
Mouillet, J., Ouyang, Y., Sadovsky, E., Kothandan, V. K., Sorenson, H. L., Badeau, L. J., Sarkar, S. N., Chu, T., Sorkin, A. D., & Sadovsky, Y. (2025) · Communications Biology · doi:10.1038/s42003-025-08923-x · Cited by 10
Fullston, T., Mitchell, M., Wakefield, S. L., & Lane, M. (2011) · Reproduction Fertility and Development · doi:10.1071/rd10292 · Cited by 9
Sarkar, P., Mischler, A., Randall, S. M., Collier, T. S., Dorman, K. F., Boggess, K., Muddiman, D. C., & Rao, B. M. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b01118 · Cited by 9
Lee, B.-K., & Kim, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.673065 · Cited by 7
The impact of opioids on the transcriptional landscape of human villous trophoblasts
Sadovsky, E., Chu, T., Barak, O., Sadovsky, Y., & Ouyang, Y. (2023) · Placenta · doi:10.1016/j.placenta.2023.10.001 · Cited by 8
Joan Hunt Senior award lecture: New tools to shed light on the ‘black box’ of pregnancy
Burton, G. J., & Turco, M. Y. (2021) · Placenta · doi:10.1016/j.placenta.2021.12.017 · Cited by 8
Self-citationTrophoblast differentiation of human embryonic stem cells
Tiruthani, K., Sarkar, P., & Rao, B. M. (2013) · Biotechnology Journal · doi:10.1002/biot.201200203 · Cited by 8
Cellular analysis of trophoblast and placenta
Wong, F., & Cox, B. (2016) · Placenta · doi:10.1016/j.placenta.2016.11.015 · Cited by 8
Epigenetic control of cell invasion – the trophoblast model
Šerman, A., Simon, F., Fabijanović, D., & Šerman, L. (2012) · BioMolecular Concepts · doi:10.1515/bmc-2012-0019 · Cited by 7
Viukov, S. V., Shani, T., Bayerl, J., Sheban, D., Stelzer, Y., Novershtern, N., & Hanna, J. H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.20.492766 · Cited by 7
Strategies for Investigating Hemochorial Placentation
Renaud, S. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804239-7.00066-4 · Cited by 6
High Proliferative Placenta-Derived Multipotent Cells Express Cytokeratin 7 at Low Level
Shablii, V., Кучма, М. Д., Svitina, H. M., Skrypkina, I., Areshkov, P. O., Kyryk, V. M., Bukreieva, T., Nikulina, V. V., Шаблий, Ю. Н., & Лобынцева, Г. С. (2019) · BioMed Research International · doi:10.1155/2019/2098749 · Cited by 6
ELF5, normal mammary development and the heterogeneous phenotypes of breast cancer
Gallego‐Ortega, D., Oakes, S. R., Lee, H. J., Blyth, C., & Ormandy, C. J. (2013) · Breast Cancer Management · doi:10.2217/bmt.13.50 · Cited by 6
Stem Cells in the Reproductive System
Kyurkchiev, S., Gandolfi, F., Hayrabedyan, S., Brevini, T. A. L., Dimitrov, R., Fitzgerald, J. S., Asma, J., Mourdjeva, M., Photini, S. M., Spencer, P., et al. (2012) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2012.01140.x · Cited by 5
Placental Anatomy and Physiology
Burton, G. J., Sibley, C. P., & Jauniaux, E. R. M. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1935-2.00001-6 · Cited by 5
Self-citationRomanek, J. (2013) · Annals of Animal Science · doi:10.2478/aoas-2013-0044 · Cited by 5
Basic Structure of a Placental Villus
Burton, G. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-84725-8_6 · Cited by 5
Self-citationEarly Development of the Human Placenta
Burton, G. J., & Jauniaux, E. R. M. (2021) · Springer eBooks · doi:10.1007/978-3-030-84725-8_5 · Cited by 4
Self-citationHighly efficient generation of self-renewing trophoblast from human pluripotent stem cells
Slamecka, J., Ryu, S., Tristan, C. A., Chu, P., Weber, C., Deng, T., Gedik, Y., Ormanoglu, P., Voss, T. C., Simeonov, A. M., et al. (2024) · iScience · doi:10.1016/j.isci.2024.110874 · Cited by 4
Prasad, J. D., Steenwinckel, J. V., Gunn, A. J., Bennet, L., Korzeniewski, S. J., Gressèns, P., & Dean, J. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312999 · Cited by 5
Gołębiewska, K., Martyniuk, E., & Polak, G. (2013) · Annals of Animal Science · doi:10.2478/aoas-2013-0045 · Cited by 4
Architecture of the Villous Trees
Burton, G. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-84725-8_7 · Cited by 4
Self-citationIntrauterine growth restriction
Kingdom, J. C., Walker, M. G., Drewlo, S., & Keating, S. J. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511997778.036 · Cited by 4
Trophoblast stem cell derivation from naive and primed hPSC enables ELF5 functional analysis
Sokka, J., Lapinsuo, E., Kvist, J., Jalil, S., Yoshihara, M., Weltner, J., Lanner, F., Kere, J., Balboa, D., Otonkoski, T., et al. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102637 · Cited by 3
Organoids in modeling human trophoblast development
Beristain, A. G., & McNeill, G. L. (2025) · Fertility and Sterility · doi:10.1016/j.fertnstert.2025.10.004 · Cited by 3
Anvar, Z., Chakchouk, I., Sharif, M., Mahadevan, S. K., Su, L., Anikar, S. S., Naini, F. A., Utama, B., & den Veyver, I. B. V. (2023) · Reproductive Sciences · doi:10.1007/s43032-023-01334-5 · Cited by 3
Innovations in Placental Pathology
Pantham, P., Soncin, F., Zhang‐Rutledge, K., Srinivasan, S., Lamale‐Smith, L. M., Laurent, L. C., & Parast, M. M. (2021) · Springer eBooks · doi:10.1007/978-3-030-84725-8_31 · Cited by 3
A blastocyst-derived in vitro model of the human chorionPreprint
Schwarz, L. C., Shannon, M. J., McNeill, G. L., Sakata, R. C., Rosa, V. S., Cheah, K., Keller, L., Snell, P., Christie, L., Elder, K. T., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.06.668884 · Cited by 3
Placental Anatomy and Physiology
Burton, G. J., Sibley, C. P., & Jauniaux, E. R. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-32108-2.00001-9 · Cited by 2
Self-citationRapid retinoic acid-induced trophoblast cell model from human induced pluripotent stem cells
Lemke, K. A., Sarkar, C. A., & Azarin, S. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-68952-0 · Cited by 2
Jurkovic, I., Gecek, I., Škrtić, A., Partl, J. Z., Martić, T. N., Šerman, A., Ljubanović, D. G., & Šerman, L. (2016) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2016.1210596 · Cited by 2
Arginine methyltransferase PRMT1 equipoises trophoblast development to prevent early pregnancy loss
Dasgupta, P., Kumar, R., Ray, S. S., Roy, N., Niloy, A. J., VALLAKATI, M., Marsh, C. A., Arnold, S. J., & Paul, S. (2026) · Nature Communications · doi:10.1038/s41467-026-75452-4 · Cited by 1
Ezashi, T., Telugu, B. P. V. L., & Michael, R. (2011) · InTech eBooks · doi:10.5772/15367 · Cited by 1
Derivation and Invasive Function of Trophoblast from Human Pluripotent Stem Cells
Moore, H. D. M., & Udayashankar, R. (2012) · Springer eBooks · doi:10.1007/978-94-007-2993-3_10 · Cited by 1
Self-citationThe Role of Nodal in the Regulation of Bi-Potential Trophoblast Progenitor Cells
Cloutier-Bosworth, A. (2012) · Scholarship@Western (Western University) · Cited by 1
The Centre for Trophoblast Research: improving health through placental research
Burton, G. J. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.02.026 · Cited by 1
Self-citationMoffett, A., & Burton, G. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-84725-8_8 · Cited by 2
Self-citationStem Cells Derived From the Placental Villi
James, J. L., McGlashan, S. R., & Chamley, L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812015-6.00014-5 · Cited by 1
Zhou, X., Zhou, C., Sun, Y., Liu, D., Kong, S., Lu, J., Qi, H., & Wang, H. (2019) · Maternal-Fetal Medicine · doi:10.1097/fm9.0000000000000023 · Cited by 1
Strategies for investigating hemochorial placentation
Renaud, S. J., & Soares, M. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382032-7.10077-3 · Cited by 1
Aplin, J. (2013) · American Journal of Human Biology · doi:10.1002/ajhb.22391
Lonczak, A. (2013) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3ms3rg4
Molecular Regulation of Human Extravillous Trophoblast Development
Pollheimer, J., & Knöfler, M. (2015) · CRC Press eBooks · doi:10.1201/b19151-4
Characterizing a model of early human placenta
Karvas, R. M. (2020) · doi:10.32469/10355/83764
Strategies for investigating hemochorial placentation
Renaud, S. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89773-0.00066-7
A Comprehensive Roadmap of Human Placental Development in vitroPreprint
Slamecka, J., Tristan, C. A., Ryu, S., Chu, P., Weber, C., Deng, T., Gedik, Y., Ormanoglu, P., Michael, S., Voss, T. C., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.07.487558
Burton, G. J., & Jauniaux, E. R. M. (2017) · Cambridge University Press eBooks · doi:10.1017/9781139976787.004
Self-citationEpigenetic regulation of placental function
Nishi, K., & Balasinor, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821785-6.00006-2
Characterization of cytotrophoblast cell population dynamics throughout pregnancyPreprint
Schäffers, O. J. M., Verburgt, S., Harhangi, M. S., Broekhuizen, M., van Hengel, E. V. A., van der Meeren, L. E., Schoenmakers, S., Dekkers, D. H. W., Doff, W. A. S., Demmers, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.22.634235
Super-Enhancers in Placental Development and Diseases
Rosario, G. X., Brown, S., Karmakar, S., Rumi, M. A. K., & Nayak, N. R. (2025) · Journal of Developmental Biology · doi:10.3390/jdb13020011
Carrillo, L. (2024) · theses.fr (ABES) · doi:10.70675/20ae659az2fa6z4eeaz99bdz5557fcfb12c2
He, Y., Song, Y., Xie, B., Yang, J., Zhu, J., Xia, P., Zhao, L., Xu, D., Wang, H., & Tian, W. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c06392
Gene regulation at the early human maternal–fetal interface
Paredes, A. L., Kim, C. E., & Vento‐Tormo, R. (2026) · Nature Reviews Genetics · doi:10.1038/s41576-026-01014-5
Metadata
- Authors
- Hemberger, M., Udayashankar, R., Tesar, P., Moore, H., & Burton, G. J.
- Affiliations
- Babraham Institute (GB)
- University of Sheffield (GB)
- Case Western Reserve University (US)
- University of Cambridge (GB)
- Corresponding author
- Hemberger, Myriam
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-03-30
- Volume
- 19
- Issue
- 12
- Pages
- 2456-2467
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2134873562
- Cited by
- 181
- References
- 47
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 6 · 2023: 6 · 2022: 14 · 2021: 13 · 2020: 10 · 2019: 12 · 2018: 12 · 2017: 11 · 2016: 14 · 2015: 8 · 2014: 9 · 2013: 17 · 2012: 24
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Molecular Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Biotechnology and Biological Sciences Research Council (BBS/E/B/0000C230)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- ELF5, trophoblast stem cells, human placenta, epigenetic regulation, transcriptional regulatory networks, CDX2, Eomes, cytotrophoblast, syncytiotrophoblast, extravillous cytotrophoblast, DNA methylation, human embryonic stem cells, induced pluripotent stem cells, epiblast stem cells, fetal growth restriction, preeclampsia
- MeSH terms
- CDX2 Transcription Factor, Animals, DNA-Binding Proteins, Female, Humans, Placenta, Pregnancy, Pregnancy Complications, Stem Cells, Transcription Factors, Trophoblasts, Homeodomain Proteins, Cell Lineage, DNA Methylation, Oligonucleotide Array Sequence Analysis, T-Box Domain Proteins, Pluripotent Stem Cells, Epigenesis, Genetic, Proto-Oncogene Proteins c-ets, Mice, Gene Regulatory Networks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
