Cited by 299Muscle Physiology and DisordersNeurogenetic and Muscular Disorders ResearchInflammatory Myopathies and Dermatomyositis

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Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype

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Villalta, S. A., Rinaldi, C., Deng, B., Liu, G., Fedor, B., Tidball, J. G.·2011·Human Molecular Genetics

DOI 10.1093/hmg/ddq523PMC PMC3024048

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Abstract

M1 macrophages play a major role in worsening muscle injury in the mdx mouse model of Duchenne muscular dystrophy. However, mdx muscle also contains M2c macrophages that can promote tissue repair, indicating that factors regulating the balance between M1 and M2c phenotypes could influence the severity of the disease. Because interleukin-10 (IL-10) modulates macrophage activation in vitro and its expression is elevated in mdx muscles, we tested whether IL-10 influenced the macrophage phenotype in mdx muscle and whether changes in IL-10 expression affected the pathology of muscular dystrophy. Ablation of IL-10 expression in mdx mice increased muscle damage in vivo and reduced mouse strength. Treating mdx muscle macrophages with IL-10 reduced activation of the M1 phenotype, assessed by iNOS expression, and macrophages from IL-10 null mutant mice were more cytolytic than macrophages isolated from wild-type mice. Our data also showed that muscle cells in mdx muscle expressed the IL-10 receptor, suggesting that IL-10 could have direct effects on muscle cells. We assayed whether ablation of IL-10 in mdx mice affected satellite cell numbers, using Pax7 expression as an index, but found no effect. However, IL-10 mutation significantly increased myogenin expression in vivo during the acute and the regenerative phase of mdx pathology. Together, the results show that IL-10 plays a significant regulatory role in muscular dystrophy that may be caused by reducing M1 macrophage activation and cytotoxicity, increasing M2c macrophage activation and modulating muscle differentiation.

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Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments
Bustin, S. A., Benes, V., Garson, J. A., Hellemans, J., Huggett, J., Kubista, M., Mueller, R., Nolan, T., Pfaffl, M. W., Shipley, G. L., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.112797 · Cited by 16,303
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Dystrophin: the protein product of the Duchenne muscular dystrophy locus
Hoffman, E. P., Brown, R. H., & Kunkel, L. M. (1987) · Cell · doi:10.1016/0092-8674(87)90579-4 · Cited by 4,693
Macrophage activation and polarization
Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160
IL-10 inhibits cytokine production by activated macrophages
Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.
Fiorentino, D. F., Bond, M. W., & Mosmann, T. R. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.6.2081 · Cited by 2,733
Quantification of mRNA using real-time RT-PCR
Nolan, T., Hands, R. E., & Bustin, S. A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.236 · Cited by 2,247
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Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,244

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Woodman, K., Coles, C., Toulson, S., Gibbs, E. M., Knight, M., Mcdonagh, M., Crosbie-Watson, R. H., Lamandé, S., & White, J. (2018) · bioRxiv · doi:10.1101/288621 · Cited by 1
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Dumont, N. A. (2013) · Corpus Université Laval (Université Laval)
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(2011) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32834ccef6
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Qin, K., Li, Y., Liang, W., Lichte, P., Zhang, X., Zhao, Q., Fragoulis, A., Pufe, T., Kobbe, P., Ma, C., et al. (2022) · Shock · doi:10.1097/shk.0000000000002074
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Belios, I., Zazara, D. E., & Arck, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00111-3
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Lavine, K. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13279-7.00033-x
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Lorant, J. (2016) · theses.fr (ABES) · doi:10.70675/87808109zf52cz4402z9da6z81f59cf2d98e
Role of CTGF and TNF on fibrosis in muscular dystrophy
Steger, J. G. C. (2014) · theses.fr (ABES) · doi:10.70675/0e5cabb6zabbbz47bfza555z5a0e014f1c39
Cellules souches dérivées du muscle humain « MuStem » : modalités de préparation in vitro et caractéristiques biologiques pour une application clinique
Saury, C. (2017) · theses.fr (ABES) · doi:10.70675/5ad5ac21z12afz4845zb3e5zb9716e79df0b
Towards the development of a gene therapy for Pompe disease : Characterization of the immune phenotype in Pompe disease and comparison of the therapeutic potential of gene therapy with the current standard of care
Verdera, H. C. (2019) · theses.fr (ABES) · doi:10.70675/3d2d8524z211ez4408zbdfbz56c065f452a1
Formulation d'hydrogels injectables poreux et modulables : nouvelles perspectives pour la régénération du tissu musculaire squelettique et l'évaluation de la myogénèse in vitro
Griveau, L. (2021) · doi:10.70675/f23709abz6cebz44a3za064zc73bec804426
Leflunomide-inhibited STAT1 activity ameliorates intramuscular M1 macrophage infiltration and promotes muscle regeneration in Duchenne muscular dystrophy.
Hu, W., Tong, H., Zhu, M., Wang, H., Huang, X.-F., Fan, S., Guo, G., Ismail, M., Zhao, L., Li, X.-H., et al. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70518
Inhibiting trained immunity in Duchenne muscular dystrophy enhances muscle regeneration and reduces fat depositionPreprint
Esposito, L., Bracaglia, A., Picca, A., Cavioli, G., Ruggieri, V., Nicoletti, C., Madaro, L., Riera, C. S., Coletti, D., Ranzenigo, A., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10008020/v1
Allium tuberosum extract attenuates dexamethasone-induced muscle atrophy by modulating the PI3K/AKT pathway
Bae, S., & Park, J. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109978
Therapeutic Potential of SAT-3247 in a Canine Model of Duchenne Muscular DystrophyPreprint
Rayagiri, S., Smid, J. K., Lambert, P., Jaquith, J., Murray, T., Mitchell, R., Gleeson, F., Monast, J. G., Teixeira, J. A., Yue, Y., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-11220671/v1
The annexin A1 mimetic peptide Ac2-26 promotes inflammation-resolution and stimulates skeletal muscle regeneration in the mdx mouse model of Duchenne muscular dystrophyPreprint
Rehman, H. J. U., Lu, X., Nasrallah, S. M., Sharma, B., Lies, S. A., Adhikari, S., Welc, S. S., & Markworth, J. F. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.05.756885

Authors: Villalta, S. A., Rinaldi, C., Deng, B., Liu, G., Fedor, B., & Tidball, J. G.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Tidball, J. G.
ORCID: Villalta, S. A.
Rinaldi, C.
Deng, B.
Tidball, J. G.
Venue: Human Molecular Genetics
Publisher: Oxford University Press (OUP)
Published: 2010-11-30
Volume: 20
Issue: 4
Pages: 790-805
ISSN: 0964-6906 (ISSN-L)
1460-2083
DOI: 10.1093/hmg/ddq523
PMC: PMC3024048
OpenAlex: W2149152441
Cited by: 299
References: 67
Citations by year: 2026: 10 · 2025: 19 · 2024: 11 · 2023: 13 · 2022: 18 · 2021: 20 · 2020: 14 · 2019: 26 · 2018: 25 · 2017: 25 · 2016: 16 · 2015: 24 · 2014: 23 · 2013: 21 · 2012: 21
FWCI: 7.17
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Human Molecular Genetics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Muscular Dystrophy Association (157881)
National Institutes of Health (5r01ar040343-12, AR40343)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR47721, R01 AR 40343, R01AR047721, F31AR054724)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Genetics (clinical) › Neurogenetic and Muscular Disorders Research
Health Sciences › Medicine › Rheumatology › Inflammatory Myopathies and Dermatomyositis
Keywords: IL-10, Duchenne muscular dystrophy, mdx mice, M1 macrophages, M2c macrophages, macrophage polarization, muscle damage, inducible nitric oxide synthase, macrophage cytotoxicity, IL-10 receptor, satellite cells, Pax7, myogenin, muscle regeneration, myogenesis
MeSH terms: Animals, Cell Differentiation, Cell Line, Macrophage Activation, Macrophages, Mice, Inbred C57BL, Phagocytosis, Phenotype, Regeneration, Interleukin-10, Mice, Inbred mdx, Muscle, Skeletal, Muscular Dystrophy, Duchenne, Mice, Receptors, Interleukin-10

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Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype

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