The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Distinct DNA methylation changes highly correlated with chronological age in the human brain
Open accessAbstract
Methylation at CpG sites is a critical epigenetic modification in mammals. Altered DNA methylation has been suggested to be a central mechanism in development, some disease processes and cellular senescence. Quantifying the extent and identity of epigenetic changes in the aging process is therefore potentially important for understanding longevity and age-related diseases. In the current study, we have examined DNA methylation at >27,000 CpG sites throughout the human genome, in frontal cortex, temporal cortex, pons and cerebellum from 387 human donors between the ages of 1 and 102 years. We identify CpG loci that show a highly significant, consistent correlation between DNA methylation and chronological age. The majority of these loci are within CpG islands and there is a positive correlation between age and DNA methylation level. Lastly, we show that the CpG sites where the DNA methylation level is significantly associated with age are physically close to genes involved in DNA binding and regulation of transcription. This suggests that specific age-related DNA methylation changes may have quite a broad impact on gene expression in the human brain.
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Cites
CpG Islands in vertebrate genomes
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Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
Gibbs, J. R., van der Brug, M. P., Hernandez, D. G., Traynor, B. J., Nalls, M. A., Lai, S.-L., Arepalli, S., Dillman, A., Rafferty, I. P., Troncoso, J., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000952 · Cited by 769
Self-citationHuman aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
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Cited by
DNA methylation age of human tissues and cell types
Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
Horvath, S., & Raj, K. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0004-3 · Cited by 3,095
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Self-citationAlzheimer’s disease: pathogenesis, diagnostics, and therapeutics
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Ageing, neurodegeneration and brain rejuvenation
Wyss-Coray, T. (2016) · Nature · doi:10.1038/nature20411 · Cited by 1,147
Metadata
- Authors
- Hernandez, D. G., Nalls, M. A., Gibbs, J. R., Arepalli, S., van der Brug, M., Chong, S., Moore, M., Longo, D. L., Cookson, M. R., Traynor, B. J., & Singleton, A. B.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-07
- Volume
- 20
- Issue
- 6
- Pages
- 1164-1172
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2105767248
- Cited by
- 375
- References
- 13
- FWCI
- 14.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Hernandez, D. G., Nalls, M. A., Gibbs, J. R., Arepalli, S., van der Brug, M., Chong, S., Moore, M., Longo, D. L., Cookson, M. R., Traynor, B. J., & Singleton, A. B. (2011). Distinct DNA methylation changes highly correlated with chronological age in the human brain. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddq561
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