Ageing, neurodegeneration and brain rejuvenation
Open accessAbstract
Although systemic diseases take the biggest toll on human health and well-being, increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the essence of being. Ageing, which is fundamental to neurodegeneration and dementia, affects every organ in the body and seems to be encoded partly in a blood-based signature. Indeed, factors in the circulation have been shown to modulate ageing and to rejuvenate numerous organs, including the brain. The discovery of such factors, the identification of their origins and a deeper understanding of their functions is ushering in a new era in ageing and dementia research.
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The removal of circulating pro-ageing factors holds the potential to revitalize the brain in animal studies.
“The removal of circulating pro-ageing factors also holds the potential to revitalize the brain in animal studies.391”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [391]
The ability of interventions not only to slow the rate of aging but actually to rejuvenate cells and tissues seemingly by reversing aging processes expands the spectrum of healthspan-promoting treatments.
“Furthermore, the ability of interventions not only to slow the rate of aging but actually to rejuvenate cells and tissues seemingly by reversing aging processes expands the spectrum of healthspan-promoting treatments.79,80,81,82,83”
From Asynchronous, contagious and digital aging (2021) · cites this paper as [81]
The study details ligand-receptor interactions among nearly all cell types in the brain that are modified by aging.
“Given that cell non-autonomous changes are also known to regulate aging-dependent changes 2,3 , we also detail ligand-receptor interactions among nearly all the cell types in the brain that are modified by aging.”
From Single-cell transcriptomic profiling of the aging mouse brain (2019) · cites this paper as [2]
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
DNA methylation age of human tissues and cell types
Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075 · see citing works
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
Self-citationMeta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336 · see citing works
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works
<i>TREM2</i> Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020 · see citing works
Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease
Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558 · see citing works
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works
Initiative, T. A. D. N., Hollingworth, P., CHARGE consortium, EADI1 consortium, Harold, D., Sims, R., Gerrish, A., Lambert, J.-C., Carrasquillo, M. M., Abraham, R., et al. (2011) · Nature Genetics · doi:10.1038/ng.803 · Cited by 1,997 · see citing works
Preclinical Alzheimer’s Disease: Definition, Natural History, and Diagnostic Criteria
Dubois, B., Hampel, H., Feldman, H. H., Scheltens, P., Aisen, P., Andrieu, S., Bakardjian, H., Benali, H., Bertram, L., Blennow, K., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.002 · Cited by 1,925 · see citing works
Naj, A. C., Jun, G., Beecham, G. W., Wang, L.-S., Vardarajan, B. N., Buros, J., Gallins, P. J., Buxbaum, J. D., Jarvik, G. P., Crane, P. K., et al. (2011) · Nature Genetics · doi:10.1038/ng.801 · Cited by 1,901 · see citing works
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works
Self-citationIntegrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Zhang, B., Gaiteri, C., Bodea, L.-G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.030 · Cited by 1,657 · see citing works
Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study
Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588 · see citing works
Pickford, F., Masliah, E., Britschgi, M., Lucin, K. M., Narasimhan, R., Jaeger, P. A., Small, S., Spencer, B., Rockenstein, E., Levine, B., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33585 · Cited by 1,186 · see citing works
Self-citationMicroglial brain region-dependent diversity and selective regional sensitivities to aging
Grabert, K., Michoel, T., Karavolos, M. H., Clohisey, S., Baillie, J. K., Stevens, M. P., Freeman, T. C., Summers, K. M., & McColl, B. W. (2016) · Nature Neuroscience · doi:10.1038/nn.4222 · Cited by 1,151 · see citing works
Systemic inflammation and disease progression in Alzheimer disease
Holmes, C., Cunningham, C., Zotova, E., Woolford, J., Dean, C., Kerr, S., Culliford, D., & Perry, V. H. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b6bb95 · Cited by 1,139 · see citing works
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081 · see citing works
Self-citationClassification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
Ray, S., Britschgi, M., Herbert, C., Takeda-Uchimura, Y., Boxer, A., Blennow, K., Friedman, L. F., Galasko, D. R., Jutel, M., Karydas, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1653 · Cited by 1,048 · see citing works
Self-citationVascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
Katsimpardi, L., Litterman, N. K., Schein, P. A., Miller, C. M., Loffredo, F. S., Wojtkiewicz, G. R., Chen, J. W., Lee, R. T., Wagers, A. J., & Rubin, L. L. (2014) · Science · doi:10.1126/science.1251141 · Cited by 1,037 · see citing works
Trejo, J. L., Carro, E., & Torres-Alemán, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01628.2001 · Cited by 1,017 · see citing works
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
De Jager, P. L., Srivastava, G., Lunnon, K., Burgess, J., Schalkwyk, L. C., Yu, L., Eaton, M. L., Keenan, B. T., Ernst, J., McCabe, C., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3786 · Cited by 956 · see citing works
Loffredo, F. S., Steinhauser, M. L., Jay, S. M., Gannon, J., Pancoast, J. R., Yalamanchi, P., Sinha, M., Dall’Osso, C., Khong, D., Shadrach, J. L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.015 · Cited by 948 · see citing works
A pathophysiological framework of hippocampal dysfunction in ageing and disease
Small, S. A., Schobel, S., Buxton, R. B., Witter, M. P., & Barnes, C. A. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3085 · Cited by 920 · see citing works
Herskind, A. M., McGue, M., Holm, N. V., Sørensen, T. I. A., Harvald, B., & Vaupel, J. W. (1996) · Human Genetics · doi:10.1007/bf02185763 · Cited by 879 · see citing works
Compromised autophagy and neurodegenerative diseases
Menzies, F. M., Fleming, A., & Rubinsztein, D. C. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3961 · Cited by 851 · see citing works
Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
Zhang, G., Li, J., Purkayastha, S., Tang, Y., Zhang, H., Yin, Y., Li, B., Liu, G., & Cai, D. (2013) · Nature · doi:10.1038/nature12143 · Cited by 834 · see citing works
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle
Sinha, M., Jang, Y. C., Oh, J., Khong, D., Wu, E. Y., Manohar, R., Miller, C., Regalado, S. G., Loffredo, F. S., Pancoast, J. R., et al. (2014) · Science · doi:10.1126/science.1251152 · Cited by 824 · see citing works
The mitochondrial‐lysosomal axis theory of aging
Brunk, U. T., & Terman, A. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02869.x · Cited by 729 · see citing works
Immune activation in brain aging and neurodegeneration: too much or too little?
Lucin, K. M., & Wyss-Coray, T. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.039 · Cited by 679 · see citing works
Self-citationRejuvenation of Regeneration in the Aging Central Nervous System
Ruckh, J. M., Zhao, J.-W., Shadrach, J. L., van Wijngaarden, P., Rao, T. N., Wagers, A. J., & Franklin, R. J. M. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.019 · Cited by 649 · see citing works
Microglial dysfunction in brain aging and Alzheimer's disease
Mosher, K. I., & Wyss-Coray, T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.008 · Cited by 618 · see citing works
Self-citationAge-related myelin degradation burdens the clearance function of microglia during aging
Safaiyan, S., Kannaiyan, N., Snaidero, N., Brioschi, S., Biber, K., Yona, S., Edinger, A. L., Jung, S., Rossner, M. J., & Simons, M. (2016) · Nature Neuroscience · doi:10.1038/nn.4325 · Cited by 604 · see citing works
Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease
Gjoneska, E., Pfenning, A. R., Mathys, H., Quon, G., Kundaje, A., Tsai, L.-H., & Kellis, M. (2015) · Nature · doi:10.1038/nature14252 · Cited by 576 · see citing works
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
Lunnon, K., Smith, R., Hannon, E., De Jager, P. L., Srivastava, G., Volta, M., Troakes, C., Al-Sarraj, S., Burrage, J., Macdonald, R., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3782 · Cited by 574 · see citing works
Protective effects of NSAIDs on the development of Alzheimer disease
Vlad, S. C., Miller, D. R., Kowall, N. W., & Felson, D. T. (2008) · Neurology · doi:10.1212/01.wnl.0000311269.57716.63 · Cited by 535 · see citing works
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
Smith, L. K., He, Y., Park, J.-S., Bieri, G., Snethlage, C. E., Lin, K., Gontier, G., Wabl, R., Plambeck, K. E., Udeochu, J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3898 · Cited by 500 · see citing works
Self-citationGenetic influence on human lifespan and longevity
Hjelmborg, J., Iachine, I. A., Skytthe, A., Vaupel, J. W., McGue, M. K., Koskenvuo, M. J., Kaprio, J. A., Pedersen, N. L., & Christensen, K. (2006) · Human Genetics · doi:10.1007/s00439-006-0144-y · Cited by 498 · see citing works
Aβ Secretion and Plaque Formation Depend on Autophagy
Nilsson, P., Loganathan, K., Sekiguchi, M., Matsuba, Y., Hui, K., Tsubuki, S., Tanaka, M., Iwata, N., Saito, T., & Saido, T. C. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.042 · Cited by 459 · see citing works
Anti-inflammatory drugs and Alzheimer disease
McGeer, P. L., McGeer, E. G., Rogers, J., & Sibley, J. T. (1990) · The Lancet · doi:10.1016/0140-6736(90)91101-f · Cited by 437 · see citing works
Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients
Horvath, S., & Ritz, B. R. (2015) · Aging · doi:10.18632/aging.100859 · Cited by 435 · see citing works
Distinct DNA methylation changes highly correlated with chronological age in the human brain
Hernandez, D. G., Nalls, M. A., Gibbs, J. R., Arepalli, S., van der Brug, M., Chong, S., Moore, M., Longo, D. L., Cookson, M., Traynor, B. J., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddq561 · Cited by 376 · see citing works
Deep biomarkers of human aging: Application of deep neural networks to biomarker development
Putin, E., Mamoshina, P., Aliper, A. M., Korzinkin, M., Moskalev, A., Kolosov, A., Ostrovskiy, A., Cantor, C. R., Vijg, J., & Zhavoronkov, A. A. (2016) · Aging · doi:10.18632/aging.100968 · Cited by 373 · see citing works
MHC Class I: An Unexpected Role in Neuronal Plasticity
Shatz, C. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.044 · Cited by 369 · see citing works
Caccamo, A., Magrì, A., Medina, D. X., Wisely, E. V., López‐Aranda, M. F., Silva, A. J., & Oddo, S. (2013) · Aging Cell · doi:10.1111/acel.12057 · Cited by 362 · see citing works
Salminen, A., Ojala, J., Kaarniranta, K., Haapasalo, A., Hiltunen, M., & Soininen, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07738.x · Cited by 333 · see citing works
The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review
Nixon, R., Cataldo, A., & Mathews, P. (2000) · Neurochemical Research · doi:10.1023/a:1007675508413 · Cited by 332 · see citing works
Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study
Kawas, C. H., Kim, R. C., Sonnen, J. A., Bullain, S. S., Trieu, T., & Corrada, M. M. (2015) · Neurology · doi:10.1212/wnl.0000000000001831 · Cited by 303 · see citing works
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works
Suspected non-Alzheimer disease pathophysiology — concept and controversy
Jack, C. R., Knopman, D. S., Chételat, G., Dickson, D. W., Fagan, A. M., Frisoni, G. B., Jagust, W. J., Mormino, E. C., Petersen, R. C., Sperling, R. A., et al. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.251 · Cited by 299 · see citing works
Baruch, K., Ron‐Harel, N., Gal, H., Deczkowska, A., Shifrut, E., Ndifon, W. O., Mirlas-Neisberg, N., Cardon, M., Vaknin, I., Cahalon, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211270110 · Cited by 296 · see citing works
Conboy, M. J., Conboy, I. M., & Rando, T. A. (2013) · Aging Cell · doi:10.1111/acel.12065 · Cited by 265 · see citing works
Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging
Sonntag, W. E., Ramsey, M. M., & Carter, C. S. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.02.001 · Cited by 254 · see citing works
Proinflammatory cytokines, sickness behavior, and Alzheimer disease
Holmes, C., Cunningham, C. M., Zotova, E., Culliford, D. J., & Perry, V. H. (2011) · Neurology · doi:10.1212/wnl.0b013e318225ae07 · Cited by 242 · see citing works
Contrasting Pathology of the Stress Granule Proteins TIA-1 and G3BP in Tauopathies
Vanderweyde, T. E., Yu, W. H., Varnum, M. M., Liu‐Yesucevitz, L., Citro, A., Ikezu, T., Duff, K., & Wolozin, B. L. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1592-12.2012 · Cited by 235 · see citing works
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
Hu, W. T., Holtzman, D. M., Fagan, A. M., Shaw, L. M. J., Perrin, R. J., Arnold, S. E., Grossman, M., Xiong, C., Craig‐Schapiro, R., Clark, C. M., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318266fa70 · Cited by 234 · see citing works
Whole-Genome Sequencing of a Healthy Aging Cohort
Erikson, G. A., Bodian, D. L., Rueda, M., Molparia, B., Scott, E. R., Zeeland, A. A. S., Topol, S. E., Wineinger, N. E., Niederhuber, J. E., Topol, E. J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.03.022 · Cited by 230 · see citing works
Aging-associated Changes in Human Brain
Mrak, R. E., Griffin, W. S. T., & Graham, D. I. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199712000-00001 · Cited by 229 · see citing works
Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology
Sattlecker, M., Kiddle, S. J., Newhouse, S., Proitsi, P., Nelson, S., Williams, S., Johnston, C., Killick, R., Simmons, A., Westman, E., et al. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.09.016 · Cited by 223 · see citing works
Plasma Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease
Soares, H. D. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.1070 · Cited by 218 · see citing works
Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin
Baht, G. S., Silkstone, D., Vi, L., Nadesan, P., Amani, Y., Whetstone, H., Wei, Q., & Alman, B. A. (2015) · Nature Communications · doi:10.1038/ncomms8131 · Cited by 211 · see citing works
Biochemistry and Biology of GDF11 and Myostatin
Walker, R. G., Poggioli, T., Katsimpardi, L., Buchanan, S. M., Oh, J., Wattrus, S. J., Heidecker, B., Fong, Y. W., Rubin, L. L., Ganz, P., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.308391 · Cited by 210 · see citing works
Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease
Schafer, M. J., Atkinson, E. J., Vanderboom, P. M., Kotajarvi, B. R., White, T. A., Moore, M. M., Bruce, C. J., Greason, K. L., Suri, R. M., Khosla, S., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.023 · Cited by 206 · see citing works
Altered Proteins in the Aging Brain
Elobeid, A., Libard, S., Leino, M., Popova, S. N., & Alafuzoff, I. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw002 · Cited by 202 · see citing works
Plasma proteins predict conversion to dementia from prodromal disease
Hye, A., Riddoch‐Contreras, J., Baird, A. L., Ashton, N. J., Bazenet, C. E., Leung, R., Westman, E., Simmons, A., Dobson, R., Sattlecker, M., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.05.1749 · Cited by 197 · see citing works
Novel loci and pathways significantly associated with longevity
Zeng, Y., Nie, C., Min, J., Liu, X., Li, M., Chen, H., Xu, H., Wang, M., Ni, T., Li, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep21243 · Cited by 195 · see citing works
Preclinical Assessment of Young Blood Plasma for Alzheimer Disease
Middeldorp, J., Lehallier, B., Villeda, S. A., Miedema, S. S. M., Evans, E., Czirr, E., Zhang, H., Luo, J., Stan, T., Mosher, K. I., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.3185 · Cited by 153 · see citing works
Self-citationCirculating Proteomic Signatures of Chronological Age
Menni, C., Kiddle, S. J., Mangino, M., Viñuela, A., Psatha, M., Steves, C., Sattlecker, M., Buil, A., Newhouse, S., Nelson, S., et al. (2015) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu121 · Cited by 144 · see citing works
Baker, L. D., Barsness, S. M., Borson, S., Merriam, G. R., Friedman, S. D., Craft, S., & Vitiello, M. V. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.1970 · Cited by 138 · see citing works
Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants
Pilling, L. C., Atkins, J. L., Bowman, K., Jones, S. E., Tyrrell, J., Beaumont, R. N., Ruth, K. S., Tuke, M. A., Yaghootkar, H., Wood, A. R., et al. (2016) · Aging · doi:10.18632/aging.100930 · Cited by 136 · see citing works
Vasudevan, A. R., Wu, H., Xydakis, A. M., Jones, P. H., Smith, E. O., Sweeney, J. F., Corry, D. B., & Ballantyne, C. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1280 · Cited by 132 · see citing works
Pathological stress granules in Alzheimer’s disease
Ash, P. E. A., Vanderweyde, T. E., Youmans, K. L., Apicco, D. J., & Wolozin, B. (2014) · Brain Research · doi:10.1016/j.brainres.2014.05.052 · Cited by 129 · see citing works
The Epidemiology of Longevity and Exceptional Survival
Newman, A. B., & Murabito, J. M. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs013 · Cited by 126 · see citing works
Amyloid negativity in patients with clinically diagnosed Alzheimer disease and MCI
Landau, S. M., Horng, A., Fero, A., Jagust, W. J., Initiative, A. D. N., Initiative, A. D. N., Weiner, M. W., Aisen, P., Weiner, M. W., Aisen, P., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002576 · Cited by 126 · see citing works
The epigenetic landscape of Alzheimer's disease
Lord, J., & Cruchaga, C. (2014) · Nature Neuroscience · doi:10.1038/nn.3792 · Cited by 122 · see citing works
Nonsteroidal anti‐inflammatory drug use and the risk of cognitive impairment and Alzheimer's disease
Côté, S., Carmichael, P., Verreault, R., Lindsay, J., Lefèbvre, J., & Laurin, D. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.03.012 · Cited by 122 · see citing works
Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication
Salpeter, S. J., Khalaileh, A., Weinberg-Corem, N., Ziv, O., Glaser, B., & Dor, Y. (2013) · Diabetes · doi:10.2337/db13-0160 · Cited by 122 · see citing works
Friedlander, A. L., Butterfield, G. E., Moynihan, S., Grillo, J., Pollack, M., Holloway, L., Friedman, L., Yesavage, J. A., Matthias, D., Lee, S., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7377 · Cited by 118 · see citing works
Linnartz‐Gerlach, B., & Neumann, H. (2012) · Glia · doi:10.1002/glia.22359 · Cited by 117 · see citing works
Genetic factors associated with longevity: A review of recent findings
Shadyab, A. H., & LaCroix, A. Z. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.10.005 · Cited by 112 · see citing works
Effect of exercise training on plasma visfatin and eotaxin levels
Choi, K. M., Kim, J. H., Cho, G. J., Baik, S. H., Park, H. S., & Kim, S. M. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0127 · Cited by 112 · see citing works
Age-Dependent Changes in the Cerebrospinal Fluid Proteome by Slow Off-Rate Modified Aptamer Array
Baird, G. S., Nelson, S. K., Keeney, T. R., Stewart, A., Williams, S., Kraemer, S., Peskind, E. R., & Montine, T. J. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.10.024 · Cited by 110 · see citing works
Plasma Based Markers of [11C] PiB-PET Brain Amyloid Burden
Kiddle, S. J., Thambisetty, M., Simmons, A., Riddoch-Contreras, J., Hye, A., Westman, E., Pike, I., Ward, M., Johnston, C., Lupton, M. K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044260 · Cited by 100 · see citing works
Meta-analysis of genetic variants associated with human exceptional longevity
Paola Sebastiani, B., Bae, H. T., Sun, F. X., Andersen, S. L., Daw, E. W., Malovini, A. L., Kojima, T., Hirose, N., Schupf, N., Puca, A. A., et al. (2013) · Aging · doi:10.18632/aging.100594 · Cited by 91 · see citing works
Blood-Borne Revitalization of the Aged Brain
Castellano, J. M., Kirby, E. D., & Wyss-Coray, T. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1616 · Cited by 83 · see citing works
Self-citationJohnstone, D. M., Milward, E. A., Berretta, R. E., Moscato, P., & Initiative, A. D. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034341 · Cited by 82 · see citing works
Young, Proliferative Thymic Epithelial Cells Engraft and Function in Aging Thymuses
Kim, M., Miller, C. M., Shadrach, J. L., Wagers, A. J., & Serwold, T. F. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403158 · Cited by 75 · see citing works
Molecular Insights into the Pathogenesis of Alzheimer's Disease and Its Relationship to Normal Aging
Podtelezhnikov, A. A., Tanis, K. Q., Nebozhyn, M., Ray, W. J., Stone, D. J., & Loboda, A. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029610 · Cited by 75 · see citing works
A comprehensive profile of ChIP-Seq-based PU.1/Spi1 target genes in microglia.
Satoh, J.-I., Asahina, N., Kitano, S., & Kino, Y. (2014) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s19711 · Cited by 74 · see citing works
Lalli, M. A., Bettcher, B. M., Arcila, M. L., Garcia, G., Guzman, C., Madrigal, L., Ramirez, L., Acosta-Uribe, J., Baena, A., Wojta, K. J., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.131 · Cited by 73 · see citing works
Immunotherapy for Alzheimer’s disease: past, present and future
Spencer, B. J., & Masliah, E. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00114 · Cited by 73 · see citing works
Britschgi, M., Rufibach, K., Huang, S. L. B., Clark, C. M., Kaye, J. A., Li, G., Peskind, E. R., Quinn, J. F., Galasko, D. R., & Wyss‐Coray, T. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.008862 · Cited by 71 · see citing works
Self-citationEnhancement of Memories by Systemic Administration of Insulin-Like Growth Factor II
Stern, S. A., Kohtz, A. S., Pollonini, G., & Alberini, C. M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.69 · Cited by 68 · see citing works
GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium
Matteini, A. M., Tanaka, T., Karasik, D., Atzmon, G., Chou, W., Eicher, J. D., Johnson, A. D., Arnold, A. M., Callisaya, M. L., Davies, G., et al. (2016) · Aging Cell · doi:10.1111/acel.12468 · Cited by 64 · see citing works
Non-Steroidal Anti-Inflammatory Drug Use and the Risk of Parkinson’s Disease
Manthripragada, A. D., Schernhammer, E. S., Qiu, J., Friis, S., Wermuth, L., Olsen, J. H., & Ritz, B. R. (2011) · Neuroepidemiology · doi:10.1159/000325653 · Cited by 57 · see citing works
Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain
Jaeger, P. A., Lucin, K. M., Britschgi, M., Vardarajan, B. N., Huang, R.-P., Kirby, E. D., Abbey, R. J., Boeve, B. F., Boxer, A. L., Farrer, L. A., et al. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0095-2 · Cited by 34 · see citing works
Self-citationSalpeter, S., Khalaileh, A., Weinberg-Corem, N., Ziv, O., Gläser, B., & Dor, Y. (2013) · Diabetes · doi:10.2337/db13-er09 · Cited by 26 · see citing works
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Ageing as a risk factor for neurodegenerative disease
Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, S. G., Croteau, D. L., & Bohr, V. A. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0244-7 · Cited by 3,310 · see citing works
RNA targeting with CRISPR–Cas13
Abudayyeh, O. O., Gootenberg, J. S., Essletzbichler, P., Han, S., Joung, J., Belanto, J. J., Verdine, V., Cox, D. B. T., Kellner, M. J., Regev, A., et al. (2017) · Nature · doi:10.1038/nature24049 · Cited by 2,093 · see citing works
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
Platten, M., Nollen, E. A. A., Röhrig, U. F., Fallarino, F., & Opitz, C. A. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0016-5 · Cited by 1,586 · see citing works
cGAS–STING drives ageing-related inflammation and neurodegeneration
Gulen, M. F., Samson, N., Keller, A., Schwabenland, M., Liu, C., Glück, S., Thacker, V. V., Favre, L., Mangeat, B., Kroese, L. J., et al. (2023) · Nature · doi:10.1038/s41586-023-06373-1 · Cited by 1,074 · see citing works
Mrdjen, D., Pavlovic, A., Hartmann, F. J., Schreiner, B., Utz, S. G., Leung, B. P., Lelios, I., Heppner, F. L., Kipnis, J., Merkler, D., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.011 · Cited by 1,010 · see citing works
A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain
Davie, K., Janssens, J., Koldere, D., De Waegeneer, M., Pech, U., Kreft, Ł., Aibar, S., Makhzami, S., Christiaens, V., Bravo González-Blas, C., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.057 · Cited by 840 · see citing works
Neurodegenerative disease: models, mechanisms, and a new hope
Gitler, A. D., Dhillon, P., & Shorter, J. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030205 · Cited by 752 · see citing works
Single-cell transcriptomic profiling of the aging mouse brain
Ximerakis, M., Lipnick, S. L., Innes, B. T., Simmons, S. K., Adiconis, X., Dionne, D., Mayweather, B. A., Nguyen, L., Niziolek, Z., Ozek, C., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0491-3 · Cited by 736 · see citing works
SIRT1 and aging related signaling pathways
Chen, C., Zhou, M., Ge, Y., & Wang, X. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111215 · Cited by 693 · see citing works
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity
Nguyen, P. T., Dorman, L. C., Pan, S., Vainchtein, I. D., Han, R. T., Nakao-Inoue, H., Taloma, S. E., Barron, J. J., Molofsky, A. B., Kheirbek, M. A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.050 · Cited by 615 · see citing works
Ageing, age-related diseases and oxidative stress: What to do next?
Luo, J., Mills, K., le Cessie, S., Noordam, R., & van Heemst, D. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100982 · Cited by 581 · see citing works
Mathys, H., Peng, Z., Boix, C. A., Victor, M. B., Leary, N., Babu, S., Abdelhady, G., Jiang, X., Ng, A. P., Ghafari, K., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.039 · Cited by 495 · see citing works
A transcriptomic atlas of aged human microglia
Olah, M., Patrick, E., Villani, A.-C., Xu, J., White, C. C., Ryan, K. J., Piehowski, P., Kapasi, A., Nejad, P., Cimpean, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02926-5 · Cited by 482 · see citing works
The quest to slow ageing through drug discovery
Partridge, L., Fuentealba, M., & Kennedy, B. K. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0067-7 · Cited by 468 · see citing works
Neuroinflammation and Perioperative Neurocognitive Disorders
Subramaniyan, S., & Terrando, N. (2019) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004053 · Cited by 453 · see citing works
Ramzan, F., Khan, M. U. G., Rehmat, A., Iqbal, S., Saba, T., Rehman, A. U., & Mehmood, Z. (2019) · Journal of Medical Systems · doi:10.1007/s10916-019-1475-2 · Cited by 446 · see citing works
Yousef, H., Czupalla, C. J., Lee, D., Chen, M. B., Burke, A. N., Zera, K. A., Zandstra, J., Berber, E., Lehallier, B., Mathur, V., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0440-4 · Cited by 442 · see citing works
Self-citationMolecular and spatial signatures of mouse brain aging at single-cell resolution
Allen, W. E., Blosser, T. R., Sullivan, Z. A., Dulac, C., & Zhuang, X. (2023) · Cell · doi:10.1016/j.cell.2022.12.010 · Cited by 423 · see citing works
“nectivity or physiology(2) to senescence of glial and immune cells and the role of circulating inflammatory factors.(48) Previous transcriptomic studies have revealed widespread changes in cell state in specific cell types with age, with many of these studies highlighting a role for increased inflammation as a key asp…”
BackgroundTherapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism
Cui, Z., Zhao, X., Amevor, F. K., Du, X., Wang, Y., Li, D., Shu, G., Tian, Y., & Zhao, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.943321 · Cited by 400 · see citing works
Cole, J. H. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.03.014 · Cited by 379 · see citing works
Black Phosphorus Nanosheets as a Neuroprotective Nanomedicine for Neurodegenerative Disorder Therapy
Chen, W., Ouyang, J., Yi, X., Xu, Y., Niu, C., Zhang, W., Wang, L., Sheng, J., Deng, L., Liu, Y., et al. (2018) · Advanced Materials · doi:10.1002/adma.201703458 · Cited by 374 · see citing works
The role of mitochondrial <scp>ROS</scp> in the aging brain
Stefanatos, R., & Sanz, A. (2018) · FEBS Letters · doi:10.1002/1873-3468.12902 · Cited by 358 · see citing works
Yan, S., Tu, Z., Liu, Z., Fan, N., Yang, H., Yang, S., Yang, W., Zhao, Y., Ouyang, Z., Lai, C., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.005 · Cited by 339 · see citing works
Innate Immunity and Neurodegeneration
Labzin, L. I., Heneka, M. T., & Latz, E. (2018) · Annual Review of Medicine · doi:10.1146/annurev-med-050715-104343 · Cited by 319 · see citing works
Sanders, L. M. J., Hortobágyi, T., Gemert, S. L. B., van der Zee, E. A., & van Heuvelen, M. J. G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210036 · Cited by 319 · see citing works
Sengupta, U., & Kayed, R. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102270 · Cited by 303 · see citing works
Cellular senescence and Alzheimer disease: the egg and the chicken scenario
Saez-Atienzar, S., & Masliah, E. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0325-z · Cited by 257 · see citing works
The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration
Azam, S., Haque, M. E., Balakrishnan, R., Kim, I., & Choi, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.683459 · Cited by 257 · see citing works
Horizons in the evolution of aging
Flatt, T., & Partridge, L. (2018) · BMC Biology · doi:10.1186/s12915-018-0562-z · Cited by 255 · see citing works
Matter over mind: Liquid phase separation and neurodegeneration
Elbaum‐Garfinkle, S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev118.001188 · Cited by 244 · see citing works
Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues
Chen, M. B., Yang, A. C., Yousef, H., Lee, D., Chen, W., Schaum, N., Lehallier, B., Quake, S. R., & Wyss-Coray, T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.012 · Cited by 233 · see citing works
“…M anuscript Luminal Exposure of BECs to Young Plasma Reverses Aspects of Transcriptional Aging The plasma of young mice can rejuvenate the brains of aged mice, as assessed by enhanced neurogenesis, memory and learning, dendritic spine density, and diminished neuroinflammation (Wyss-Coray, 2016).”
InfluentialSelf-citationTanaka, M., Toldi, J., & Vécsei, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072431 · Cited by 225 · see citing works
Peripheral immune system in aging and Alzheimer’s disease
Cao, W., & Zheng, H. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0284-2 · Cited by 214 · see citing works
Kim, T., Kim, H. J., Choi, W., Lee, Y. M., Pyo, J. H., Lee, J., Kim, J., Kim, J., Kim, J., Kim, C., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00965-4 · Cited by 208 · see citing works
Old Maids: Aging and Its Impact on Microglia Function
Koellhoffer, E. C., McCullough, L. D., & Ritzel, R. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040769 · Cited by 205 · see citing works
GABAergic Inhibitory Interneuron Deficits in Alzheimer’s Disease: Implications for Treatment
Xu, Y., Zhao, M., Han, Y., & Zhang, H. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00660 · Cited by 203 · see citing works
Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism
Fernández‐Mendívil, C., Luengo, E., Trigo-Alonso, P., García‐Magro, N., Negredo, P., & López, M. G. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101789 · Cited by 197 · see citing works
Bido, S., Muggeo, S., Massimino, L., Marzi, M. J., Giannelli, S. G., Melacini, E., Nannoni, M., Gambarè, D., Bellini, E., Ordazzo, G., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26519-x · Cited by 190 · see citing works
Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?
Mayne, K., White, J. A., McMurran, C. E., Rivera, F. J., & de la Fuente, A. G. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.572090 · Cited by 167 · see citing works
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165 · see citing works
Devkota, H. P., Paudel, K. R., Khanal, S., Baral, A., Panth, N., Adhikari‐Devkota, A., Jha, N. K., Das, N., Singh, S. K., Chellappan, D. K., et al. (2022) · Molecules · doi:10.3390/molecules27165219 · Cited by 161 · see citing works
Ashraf, A., Clark, M., & So, P. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00065 · Cited by 158 · see citing works
Blood-to-brain communication in aging and rejuvenation
Bieri, G., Schroer, A. B., & Villeda, S. A. (2023) · Nature Neuroscience · doi:10.1038/s41593-022-01238-8 · Cited by 156 · see citing works
Peng, B., Yang, Q., B Joshi, R., Liu, Y., Akbar, M., Song, B.-J., Zhou, S., & Wang, X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072316 · Cited by 156 · see citing works
Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders
Choi, J. G., Kim, S. Y., Jeong, M., & Oh, M. S. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.08.010 · Cited by 155 · see citing works
Age‐ and disease‐specific changes of the kynurenine pathway in Parkinson’s and Alzheimer’s disease
Sorgdrager, F. J. H., Vermeiren, Y., van Faassen, M. H. J. R., van der Ley, C., Nollen, E. A. A., Kema, I. P., & Deyn, P. P. D. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14843 · Cited by 154 · see citing works
Cano, A., Sánchez-López, E., Ettcheto, M., López-Machado, A., Espina, M., Souto, E. B., Galindo, R., Camins, A., García, M. L., & Turowski, P. (2020) · Nanomedicine · doi:10.2217/nnm-2019-0443 · Cited by 144 · see citing works
Papadimitriou, C., Celikkaya, H., Cosacak, M. I., Mashkaryan, V., Bray, L., Bhattarai, P., Brandt, K., Hollak, H., Chen, X., He, S., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.005 · Cited by 143 · see citing works
Hassan, S. S. U., Samanta, S., Dash, R., Karpiński, T. M. M., Habibi, E., Sadiq, A., Ahmadi, A., & BUNGAU, S. G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1015835 · Cited by 139 · see citing works
Alorf, A. A., & Khan, M. U. G. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.106240 · Cited by 138 · see citing works
Castejón, M. L., Montoya, T., Alarcón‐de‐la‐Lastra, C., & Sánchéz‐Hidalgo, M. (2020) · Antioxidants · doi:10.3390/antiox9020149 · Cited by 135 · see citing works
Aging-suppressor Klotho: Prospects in diagnostics and therapeutics
Abraham, C. R., & Li, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101766 · Cited by 131 · see citing works
Singh, S., Singh, A. K., Garg, G., & Rizvi, S. I. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.11.004 · Cited by 128 · see citing works
RetractedMicroglial phagocytosis in aging and Alzheimer's disease
Gabandé‐Rodríguez, E., Keane, L., & Capasso, M. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24419 · Cited by 127 · see citing works
Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics
Zhu, Y., Ge, J., Huang, C., Liu, H., & Jiang, H. (2021) · Theranostics · doi:10.7150/thno.46436 · Cited by 125 · see citing works
Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders
Devi, S., Kumar, V., Singh, S. K., Dubey, A. K., & Kim, J.-J. (2021) · Biomedicines · doi:10.3390/biomedicines9020099 · Cited by 124 · see citing works
Asynchronous, contagious and digital aging
Rando, T. A., & Wyss-Coray, T. (2021) · Nature Aging · doi:10.1038/s43587-020-00015-1 · Cited by 121 · see citing works
Self-citationScassellati, C., Galoforo, A. C., Bonvicini, C., Esposito, C., & Ricevuti, G. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101138 · Cited by 121 · see citing works
Muscle-to-Brain Signaling Via Myokines and Myometabolites
Rai, M., & Demontis, F. (2022) · Brain Plasticity · doi:10.3233/bpl-210133 · Cited by 121 · see citing works
Rojo, A. I., Pajares, M., García‐Yagüe, Á. J., Buendía, I., LEUVEN, F. V., Yamamoto, M. P., López, M. G., & Cuadrado, A. (2018) · Redox Biology · doi:10.1016/j.redox.2018.07.006 · Cited by 119 · see citing works
Single-nucleus transcriptomic landscape of primate hippocampal aging
Zhang, H., Li, J., Ren, J., Sun, S., Ma, S., Zhang, W., Yu, Y., Cai, Y., Yan, K., Li, W., et al. (2021) · Protein & Cell · doi:10.1007/s13238-021-00852-9 · Cited by 119 · see citing works
Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease
Uddin, M. S., Yu, W. S., & Lim, L. W. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101417 · Cited by 118 · see citing works
Kim, Y., Zheng, X., Ansari, Z., Bunnell, M. C., Herdy, J. R., Traxler, L., Lee, H., Paquola, A. C. M., Blithikioti, C., Ku, M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.105 · Cited by 117 · see citing works
Feng, X., Jia, M., Cai, M., Zhu, T., Hashimoto, K., & Yang, J. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03085-y · Cited by 117 · see citing works
Cosacak, M. I., Bhattarai, P., Reinhardt, S., Petzold, A., Dahl, A., Zhang, Y., & Kizil, C. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.090 · Cited by 116 · see citing works
Gan, K. J., & Südhof, T. C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902672116 · Cited by 114 · see citing works
Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases
(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2020.03.019 · Cited by 114 · see citing works
Exercise effects on physiological function during aging
Radak, Z. O., Torma, F., Berkes, I., Goto, S., Mimura, T., Pósa, A., Balogh, L., Boldogh, I. R., Suzuki, K., Higuchi, M., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.444 · Cited by 112 · see citing works
Retinal neurodegeneration and brain MRI markers: the Rotterdam Study
Mutlu, Ü., Bonnemaijer, P. W. M., Ikram, M. A., Colijn, J. M., Cremers, L. G. M., Buitendijk, G. H. S., Vingerling, J. R., Niessen, W. J., Vernooij, M. W., Klaver, C. C. W., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.003 · Cited by 111 · see citing works
Chad, J. A., Pasternak, O., Salat, D. H., & Chen, J. J. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.07.018 · Cited by 110 · see citing works
Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases
Xiang, Y., Song, X., & Long, D. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03660-8 · Cited by 109 · see citing works
Pervin, Z., & Stephen, J. M. (2021) · AIMS neuroscience · doi:10.3934/neuroscience.2021021 · Cited by 107 · see citing works
Absolute quantitative lipidomics reveals lipidome-wide alterations in aging brain
Tu, J., Yin, Y., Xu, M., Wang, R., & Zhu, Z. (2017) · Metabolomics · doi:10.1007/s11306-017-1304-x · Cited by 106 · see citing works
Merelli, A., Rodríguez, J., Folch, J., Regueiro, M. R., Camins, A., & Lazarowski, A. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180110130253 · Cited by 105 · see citing works
The aging mouse brain: cognition, connectivity and calcium
Radulescu, C. I., Cerar, V., Haslehurst, P., Kopanitsa, M. V., & Barnes, S. J. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102358 · Cited by 105 · see citing works
Advanced model systems and tools for basic and translational human immunology
Wagar, L. E., DiFazio, R. M., & Davis, M. M. (2018) · Genome Medicine · doi:10.1186/s13073-018-0584-8 · Cited by 102 · see citing works
Neurodegenerative Disease: Roles for Sex, Hormones, and Oxidative Stress
Sumien, N., Cunningham, J. T., Davis, D., Engelland, R. E., Fadeyibi, O., Farmer, G. E., Mabry, S., Mensah-Kane, P., Trinh, O. T. P., Vann, P. H., et al. (2021) · Endocrinology · doi:10.1210/endocr/bqab185 · Cited by 102 · see citing works
A Systematic Review of the Biological Effects of Cordycepin
Radhi, M., Ashraf, S., Lawrence, S., Arendt-Tranholm, A., Wellham, P. A. D., Hafeez, A., Khamis, A. S., Thomas, R., McWilliams, D. F., & de Moor, C. H. (2021) · Molecules · doi:10.3390/molecules26195886 · Cited by 102 · see citing works
Focusing on mitochondria in the brain: from biology to therapeutics
Song, N., Mei, S., Wang, X.-X., Hu, G., & Lu, M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00409-w · Cited by 102 · see citing works
GLP1 Receptor Agonists—Effects beyond Obesity and Diabetes
Wilbon, S. S., & Kolonin, M. G. (2023) · Cells · doi:10.3390/cells13010065 · Cited by 101 · see citing works
Ozek, C., Krolewski, R. C., Buchanan, S. M., & Rubin, L. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-35716-6 · Cited by 99 · see citing works
Fernández-Francos, S., Eiró, N., Costa, L. A., Escudero-Cernuda, S., Fernández‐Sánchez, M. L., & Vizoso, F. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073576 · Cited by 98 · see citing works
Jankowska-Kieltyka, M., Roman, A., & Nalepa, I. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.647643 · Cited by 98 · see citing works
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Sun, E., Zhou, O. Y., Hauptschein, M., Rappoport, N., Xu, L., Negredo, P. N., Liu, L. A., Rando, T. A., Zou, J., & Brunet, A. (2024) · Nature · doi:10.1038/s41586-024-08334-8 · Cited by 98 · see citing works
Pomeshchik, Y., Klementieva, O., Gil, J., Martinsson, I., Hansen, M. G., de Vries, T., Sancho-Balsells, A., Russ, K., Savchenko, E., Collin, A., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.06.001 · Cited by 95 · see citing works
Curcumin nanoformulations to combat aging-related diseases
Mahjoob, M., & Stochaj, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101364 · Cited by 92 · see citing works
Classics in Chemical Neuroscience: Donepezil
Brewster, J. T., Dell’Acqua, S., Thach, D. Q., & Sessler, J. L. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00517 · Cited by 91 · see citing works
Tsoumpra, M. K., Fukumoto, S., Matsumoto, T., Takeda, S., Wood, M. J. A., & Aoki, Y. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.036 · Cited by 91 · see citing works
Rosenzweig, N., Kleemann, K. L., Rust, T., Carpenter, M., Grucci, M., Aronchik, M., Brouwer, N., Valenbreder, I., Cooper-Hohn, J., Iyer, M., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03122-3 · Cited by 90 · see citing works
Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis
Cui, L., Hou, N.-N., Wu, H., Zuo, X., Lian, Y.-Z., Zhang, C., Wang, Z., Zhang, X., & Zhu, J. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.603854 · Cited by 88 · see citing works
Culberson, J. W., Kopel, J. J., Sehar, U., & Reddy, P. H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102001 · Cited by 88 · see citing works
Aging Biomarkers: From Functional Tests to Multi‐Omics Approaches
Kudryashova, K. S., Burka, K., Kulaga, A. Y., Vorobyeva, N. S., & Kennedy, B. K. (2020) · PROTEOMICS · doi:10.1002/pmic.201900408 · Cited by 86 · see citing works
Aging biomarkers and the brain
Higgins‐Chen, A., Thrush, K., & Levine, M. E. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.01.003 · Cited by 86 · see citing works
CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer’s disease
Cherry, J. D., Stein, T. D., Tripodis, Y., Alvarez, V. E., Huber, B. R., Au, R., Kiernan, P. T., Daneshvar, D. H., Mez, J., Solomon, T. M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185541 · Cited by 85 · see citing works
Stem cells: Aging and transcriptional fingerprints
Keyes, B. E., & Fuchs, E. V. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201708099 · Cited by 84 · see citing works
Evans, A. K., Saw, N. L., Woods, C. E., Vidano, L. M., Blumenfeld, S. E., Lam, R. K., Chu, E. K., Reading, C., & Shamloo, M. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.025 · Cited by 84 · see citing works
The antioxidant activity and neuroprotective mechanism of isoliquiritigenin
Shi, D., Yang, J., Jiang, Y., Wen, L., Wang, Z., & Yang, B. J. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.016 · Cited by 83 · see citing works
Tan, H. Y., Cho, H., & Lee, L. P. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-020-00643-3 · Cited by 83 · see citing works
Brain Mitochondria, Aging, and Parkinson’s Disease
Rango, M., & Bresolin, N. (2018) · Genes · doi:10.3390/genes9050250 · Cited by 83 · see citing works
Ximerakis, M., Holton, K. M., Giadone, R. M., Ozek, C., Saxena, M., Santiago, S., Adiconis, X., Dionne, D. A., Nguyễn, L., Shah, K. M., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00373-6 · Cited by 82 · see citing works
- Authors
- Wyss-Coray, T.
- Venue
- Nature
- Published
- 2016-11
- Volume
- 539
- Issue
- 7628
- Pages
- 180-186
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5172605
- OpenAlex
- W2549552700
- Cited by
- 1,147
- References
- 99
- Citations by year
- 2026: 88 · 2025: 127 · 2024: 133 · 2023: 156 · 2022: 162 · 2021: 143 · 2020: 122 · 2019: 91 · 2018: 79 · 2017: 44 · 2015: 1 · 2012: 1
- FWCI
- 10.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute on Aging (P50AG047366, R01AG045034)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- brain aging, neurodegeneration, dementia, brain rejuvenation, circulating factors, blood-based biomarkers
- MeSH terms
- Aging, Animals, Brain, Cell Communication, Humans, Inflammation, Rejuvenation, Neurodegenerative Diseases, Proteome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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