Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms
Shulman, J. M., Imboywa, S., Giagtzoglou, N., Powers, M. P., Hu, Y., Devenport, D., Chipendo, P., Chibnik, L. B., Diamond, A., Perrimon, N., Brown, N. H., De Jager, P. L., Feany, M. B.·2014·Human Molecular Genetics
Cited by (167)
Items 101–167 of 167
- The C-Terminus of Tau Protein Plays an Important Role in Its Stability and ToxicityJunhua Geng, Lu Xia, Wanjie Li, Fei Dou · 2014 · Journal of Molecular Neuroscience
- S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathyTomoki Chiku, Hayashishita Motoki, Taro Saito, Mikiko Oka, Kanako Shinno, Yosuke Ohtake, Sawako Shimizu, Akiko Asada, Shin‐ichi Hisanaga, Koichi Iijima et al. · 2018 · Neurobiology of Aging
- The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-ActinFarzaneh Sadat Mirfakhar, Jorge Castanheira, Raquel Domingues, Jose Silva Ramalho, Cláudia Guimas Almeida · 2024 · Journal of Neuroscience
- JNK is antagonized to ensure the correct number of interommatidial cells pattern the Drosophila retinaHenry L. Bushnell, Christina E. Steidele, Kwami F. Ketosugbo, Mark B. Hellerman, Valerie Nazzaro, Ruth I. Johnson · 2017 · Developmental Biology
- The Genetic Basis of Alzheimer's DiseaseBasavaraj V. Hooli, Rudolph E. Tanzi · 2016 · Elsevier eBooks
- Potential associations between immune signaling genes, deactivated microglia, and oligodendrocytes and cortical gray matter loss in patients with long-term remitted cushing’s diseaseBauduin, S.E.E.C., den Rooijen, I.L.B., Meijer, M., van der Werff, S.J.A., Keo, A., Dzyubachyk, O., Pereira, A.M., Giltay, E.J., van der Wee, N.J.A., Meijer, O.C. et al. · 2021 · Psychoneuroendocrinology
- Dissecting the shared genetic architecture between Alzheimer’s disease and frailty: a cross-trait meta-analyses of genome-wide association studiesNitesh Enduru, Brisa Simões Fernandes, Zhongming Zhao · 2024 · Frontiers in Genetics
- The relationship between four GWAS-identified loci in Alzheimer’s disease and the risk of Parkinson's disease, amyotrophic lateral sclerosis, and multiple system atrophyYongping Chen, Bei Cao, Xueping Chen, Ruwei Ou, Qianqian Wei, Bi Zhao, Ying Wu, Lixing Yuan, Huifang Shang · 2018 · Neuroscience Letters
- FERMT2 rs17125944 polymorphism with Alzheimer's disease risk: a replication and meta-analysisQiu-Yue Zhang, Hui-Fu Wang, Zhan-Jie Zheng, Lingli Kong, Meng‐Shan Tan, Chen‐Chen Tan, Wei Zhang, Zixuan Wang, Lin Tan, Jin‐Tai Yu et al. · 2016 · Oncotarget
- Novel Susceptibility Loci for Alzheimer's DXSiseaseChristiane Reitz · 2015 · Future Neurology
- Knowledge domains and emerging trends of Genome-wide association studies in Alzheimer’s disease: A bibliometric analysis and visualization study from 2002 to 2022Fanjing Kong, Tianyu Wu, Jingyi Dai, Jie Cai, Zhenwei Zhai, Zhishan Zhu, Ying Xu, Tao Sun · 2024 · PLoS ONE
- Association of Genes Involved in the Metabolic Pathways of Amyloid-β and Tau Proteins With Sporadic Late-Onset Alzheimer’s Disease in the Southern Han Chinese PopulationXuewen Xiao, Bin Jiao, Xinxin Liao, Weiwei Zhang, Zhenhua Yuan, Lina Guo, Xin Wang, Lu Zhou, Xixi Liu, Xinxiang Yan et al. · 2020 · Frontiers in Aging Neuroscience
- Identification of Sex-Specific Genetic Variants Associated With Tau PETXin Wang, Iris Broce, Kacie Deters, Chun Chieh Fan, Sarah Jane Banks · 2022 · Neurology Genetics
- Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLDTanzeen Yusuff, Shreyasi Chatterjee, Ya‐Chu Chang, Tzu-Kang Sang, George R. Jackson · 2023 · Frontiers in Genetics
- Identification of Tau Toxicity Modifiers in the Drosophila EyePierre Dourlen · 2016 · Methods in molecular biology
- Drosophila as a model to understand autophagy deregulation in human disordersDonna Denton, Louise V. O’Keefe, Sharad Kumar · 2020 · Progress in molecular biology and translational science
- The promises of neurodegenerative disease modelingJean‐Antoine Lepesant · 2015 · Comptes Rendus Biologies
- CD2AP at the junction of nephropathy and Alzheimer’s diseaseMilène Vandal, Mohsen Janmaleki, Isabel M. Rea, Colin Gunn, Sotaro Hirai, Jeff A. Biernaskie, Justin Chun, Grant Robert Gordon, Andréy S. Shaw, Amir Sanati‐Nezhad et al. · 2025 · Molecular Neurodegeneration
- Posterior cingulate cortex microRNA dysregulation differentiates cognitive resilience, mild cognitive impairment, and Alzheimer's diseaseScott Counts, John S. Beck, Bryan Maloney, Michael H. Malek‐Ahmadi, Stephen D. Ginsberg, Elliott Jay Mufson, Debomoy K. Lahiri · 2025 · Alzheimer s & Dementia
- Genomics of Alzheimer’s diseaseMargot P. van de Weijer, Iris E. Jansen, Anouk H. A. Verboven, Ole A. Andreassen, Daniëlle Posthuma · 2019 · Elsevier eBooks
- Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative diseaseSteven M. Finkbeiner · 2020 · Neurobiology of Disease
- An updated analysis of the association between CD2-associated protein gene rs9349407 polymorphism and Alzheimer’s disease in Chinese populationShan Gao, Jia-wei Hao, Ya-nan Zhao, Xuan Li, Tao Wang, Zhifa Han, Baoliang Sun, Jingyi Sun, Guiyou Liu · 2022 · Frontiers in Neuroinformatics
- The Genetic Basis of Alzheimer’s DiseaseBasavaraj V. Hooli, Rudolph E. Tanzi · 2016 · Elsevier eBooks
- The Role of Genetics in Alzheimer's Disease and Parkinson's DiseaseTenielle Porter, Aleksandra Gozt, Francis L. Mastaglia, Simon Matthew Laws · 2019 · Wiley eBooks
- Immuno‐Regulation of Brain Region‐Specific Organoids Containing Isogenic Microglia‐Like CellsChang Liu, Justice Ene, Wenyan Lü, Falak Syed, Li Jun Sun, Ana‐Caroline Raulin, Yi Ren, Xueju Sophie Wang, Takahisa Kanekiyo, Yan Li · 2025 · Advanced Healthcare Materials
- Advances in Alzheimer’s disease: mechanistic insights and therapeutic targetsYu-Juan Jia, Yi‐Jun Ge, Bowei Li, Ying Yang, Huaqiu Chen, Jie Liu, Junhong Guo, Jin‐Tai Yu, Keqiang Ye, Jian‐Zhi Wang et al. · 2026 · Science China Life Sciences
- Genetic reduction of tyramine β hydroxylase suppresses Tau toxicity in a Drosophila model of tauopathyVaruna Nangia, Julia O’Connell, Kusha Chopra, Yaling Qing, Camille Reppert, Cynthia M. Chai, Kesshni Bhasiin, Kenneth J. Colodner · 2021 · Neuroscience Letters
- Relationship Between FERMT2 , CELF1 , COPI , CHRNA2 , and ABCA7 Genetic Polymorphisms and Alzheimer’s Disease Risk in the Southern Chinese PopulationYanfei Ding, Haijuan Chen, Yi Yan, Yinghui Qiu, Aonan Zhao, Binyin Li, Wei Lin Xu, Yulei Deng · 2023 · Journal of Alzheimer s Disease Reports
- Brazilian kefir fraction mitigates the Alzheimer-like phenotype in Drosophila melanogaster with β-amyloid overexpression modelSerena Mares Malta, Tamíris Sabrina Rodrigues, Matheus Henrique Silva, Alexandre Souza Marquez, Rafael Bernardes Ferreira, Fernanda Naves Araújo do Prado Mascarenhas, Renata Graciele Zanon, Lucas Matos Martins Bernardes, Letícia Leandro Batista, Murillo Néia Thomaz da Silva et al. · 2024 · Scientific Reports
- Ptprd deficiency promotes tau hyperphosphorylation and impairs cognitive function in aged miceAnalia Foncea-Bitrán, Nayhara Franchini, Isidora Tobar, Sebastián Thienel, Ignacio N. Retamal, Gonzalo I. Cancino, Francisca Cornejo · 2025 · Biological Research
- Bin1 and CD2AP polarize Aβ generation in neuronsRagna Sannerud, Wim G. Annaert · 2016 · EMBO Reports
- Genetic and Epigenetic Architecture of Alzheimer’s DementiaLaura Cervera‐Carles, Jordi Clarimón · 2016 · Current Genetic Medicine Reports
- CD2AP in Alzheimer's disease: Key mechanisms and therapeutic potentialYong Wang, Yun-wu Zhang · 2025 · Brain medicine :
- Insights into amyloid disease from fly modelsKo‐Fan Chen, Damian C. Crowther · 2014 · Essays in Biochemistry
- All-trans retinoic acid up-regulates the human CD2AP gene expression through Sp1/Sp3 binding sitesHua‐Guo Xu, Rui Jin, Shan Gao, Wei Ren, Li Zou, Lifei Liu, Guoping Zhou · 2015 · Immunologic Research
- Exploring the Genetic Underpinnings of Aggression in Drosophila melanogaster.Troy Takemori · 2021 · Europe PMC (PubMed Central)
- Drosophila as a Model for Human DiseasesPaul C. Marcogliese, M. Wangler · 2018 · Encyclopedia of Life Sciences
- Codon-optimized TDP-43-mediated neurodegeneration in a Drosophila model for ALS/FTLDTanzeen Yusuff, Shreyasi Chatterjee, Ya‐Chu Chang, Tzu‐Kang Sang, George R. Jackson · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular networkMilène Vandal, Ádám Institóris, Ben Korin, Colin Gunn, Suzie Lee, Ji Yeon Lee, Philippe Bourassa, Ramesh C. Mishra, Govind Peringod, Yulan Jiang et al. · 2020 · Research Square
- From genetic roots to recent advancements in gene therapy targeting amyloid beta in Alzheimer’s diseasePinar Peyvand, Pantea Allami, Nima Rezaei · 2025 · Reviews in the Neurosciences
- Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicityAnjali Bisht, Srikanth Pippadpally, Snehasis Majumder, Athulya T Gopi, Abhijit Das, Chandan Sahi, Mani Ramaswami, Vimlesh Kumar · 2024 · eLife
- [Tau Protein Induces Aberrant Alternative Splicing Changes in PS19 Transgenic Mice].Xuewen Tian, Chan Chen, Xiong Wang · 2023 · PubMed Central
- Cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Susceptibility Gene, is Required for Synaptic Transmission and ProteostasisShamsideen A. Ojelade, Tom V. Lee, Νικόλαος Γιαγτζόγλου, Lei Yu, Berrak Uğur, Lita Duraine, Zhongyuan Zuo, Vladislav Petyuk, Philip L. De Jager, David Alan Bennett et al. · 2019 · SSRN Electronic Journal
- Investigating the Role of ATP-Binding Cassette Transporters in Drosophila melanogaster Testis Stem CellsIsrael J Wipf · 2021 · Scholarship & Creative Works - Digital UNC a service of University Libraries (University of Northern Colorado)
- Adult Neuronal Expression of the Alzheimer Risk Protein CD2AP is Enriched in NGF-Responsive Basal Forebrain Neurons, where it Collocates with Rab-5 EndosomesLindsey Avery Fitzsimons, Mohammad Atif-Sheikh, Madison G. Mueth, Makaela Rice, Gareth R. Howell, Benjamin J. Harrison · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Investigating the mechanisms underlying Alzheimer's disease using a novel organotypic brain slice culture modelCara L. Croft · 2016 · Research Portal (King's College London)
- Genetic Risk Factors for Complex Forms of Alzheimer’s DiseaseCéline Bellenguez, Jean‐Charles Lambert · 2018 · Springer eBooks
- Peer Review #2 of "Computational analysis of functional SNPs in Alzheimer’s disease-associated endocytosis genes (v0.2)"2019 · PeerJ
- Peer Review #2 of "Computational analysis of functional SNPs in Alzheimer’s disease-associated endocytosis genes (v0.1)"2019 · PeerJ
- Peer Review #1 of "Computational analysis of functional SNPs in Alzheimer’s disease-associated endocytosis genes (v0.1)"2019 · PeerJ
- Genomics of Alzheimer’s diseaseRoger N. Rosenberg, Doris Lambracht‐Washington, Gang Yu, Weiming Xia · 2020 · Elsevier eBooks
- The Phylogenetic Roots of Addiction: Compulsive Drug Seeking, Natural and Drug-Sensitive Reward, and the Acquisition of Learned HabitsRobert Huber, Daniel Jacobson · 2020 · Brain Behavior and Evolution
- The effect of genes and diet on Alzheimer's disease-related molecular mechanisms : Influence of ubiquilin-1 and dietary lipidsMari Takalo · 2015 · UEF eRepo (University of Eastern Finland)
- The Alzheimer’s disease risk gene CD2AP functions in dendritic spines by remodelling F-actinFarzaneh Sadat Mirfakhar, Jorge Castanheira, Raquel Domingues, Jose Silva Ramalho, Cláudia Guimas Almeida · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Identification of Tau Toxicity Modifiers in the Drosophila EyePierre Dourlen · 2024 · Methods in molecular biology
- Additional file 2 of Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer’s diseaseJake Gockley, Kelsey S. Montgomery, William L. Poehlman, Jesse C. Wiley, Yue Liu, Ekaterina Sergeevna Gerasimov, Anna K. Greenwood, Solveig K. Sieberts, Aliza P. Wingo, Thomas S. Wingo et al. · 2021 · Figshare
- Prefoldin 5 is a microtubule-associated protein that suppresses Tau-aggregation and neurotoxicityAnjali Bisht, Srikanth Pippadpally, Snehasis Majumder, Athulya T Gopi, Abhijit Das, Chandan Sahi, Mani Ramaswami, Vimlesh Kumar · 2024 · eLife
- A New Molecular Mechanism for the Late-Onset Alzheimer's Disease Risk Gene CD2APElisabetta Battocchio · 2025 · Journal of Neuroscience
- Neuronal CD2AP Promotes Hyperphosphorylated Tau Accumulation and Propagation in Early AlzheimerQiong‐Bin Zhu, Yanan Zhang, Ling-Yu Guo, Jennifer Monteiro Fortes, Yuting Hu, Rawien A. Balesar, Dick Frans Swaab, Ai‐Min Bao · 2025 · SSRN Electronic Journal
- Prefoldin 5 is a microtubule-associated protein that suppresses Tau-aggregation and neurotoxicityAnjali Bisht, Srikanth Pippadpally, Snehasis Majumder, Athulya T Gopi, Abhijit Das, Chandan Sahi, Mani Ramaswami, Vimlesh Kumar · 2025 · eLife
- Simple in vivo models of Alzheimer's diseaseSamuel William Caito, Jennifer L. Newell-Caito · 2025 · Elsevier eBooks
- Additional file 1 of Associations of Alzheimer’s disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegenerationTan, Meng-Shan, Yang, Yu-Xiang, Xu, Wei, Wang, Hui-Fu, Lin Tan, Zuo, Chuan-Tao, Dong, Qiang, Tan, Lan, John Suckling, Jintai Yu · 2021 · Figshare
- Additional file 1 of Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer’s diseaseJake Gockley, Kelsey S. Montgomery, William L. Poehlman, Wiley, Jesse C., Yue Liu, Ekaterina Sergeevna Gerasimov, Anna K. Greenwood, Solveig K. Sieberts, Aliza P. Wingo, Wingo, Thomas S. et al. · 2021 · Figshare
- Additional file 1 of Integrated analysis of the aging brain transcriptome and proteome in tauopathyCarl Grant Mangleburg, Timothy Wu, Hari Krishna Yalamanchili, Caiwei Guo, Hsieh, Yi-Chen, Duong, Duc M., Eric B. Dammer, Philip L. De Jager, Nicholas T. Seyfried, Zhandong Liu et al. · 2020 · Figshare
- Etude des mécanismes impliquant le facteur de risque génétique FERMT2 dans le métabolisme de l’APP et ses conséquences dans le processus physiopathologique de la maladie d’AlzheimerFanny Eysert · 2019 · theses.fr (ABES)
- Contribution à l'étude des facteurs de risque pour la maladie d'Alzheimer : analyse de candidats identifiés par étude d'association pangénomique ou GWASCharlotte Bauer · 2023 · theses.fr (ABES)
- A cell-type-directed drug repurposing framework for Alzheimer's disease subtypesYaqiao Li, Xinyu Tang, Carlota Pereda Serras, Alice Tang, Tomiko Oskotsky, Marina Sirota · 2026 · Acta Pharmaceutica Sinica B