Perrimon, Norbert

Efficient proximity labeling in living cells and organisms with TurboID

Branon, T. C., Bosch, J. A., Sanchez, A. D., Udeshi, N. D., Svinkina, T., Carr, S. A., Feldman, J. L., Perrimon, N., & Ting, A. Y. (2018) · Nature Biotechnology

Biotin and Related StudiesAdvanced Fluorescence Microscopy Techniques

Cited by 2,174

Highly efficient Cas9-mediated transcriptional programming

Chavez, A., Scheiman, J., Vora, S., Pruitt, B. W., Tuttle, M., P R Iyer, E., Lin, S., Kiani, S., Guzman, C. D., Wiegand, D. J., et al. (2015) · Nature Methods

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

Cited by 1,622

Localization of apical epithelial determinants by the basolateral PDZ protein Scribble

Bilder, D., & Perrimon, N. (2000) · Nature

Developmental Biology and Gene RegulationHippo pathway signaling and YAP/TAZ

Cited by 716

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

Demontis, F., & Perrimon, N. (2010) · Cell

Genetics, Aging, and Longevity in Model OrganismsFOXO transcription factor regulation

Cited by 656

Integrated activity of PDZ protein complexes regulates epithelial polarity

Bilder, D., Schober, M., & Perrimon, N. (2003) · Nature Cell Biology

Developmental Biology and Gene RegulationHippo pathway signaling and YAP/TAZ

Cited by 435

High-throughput RNAi screening in cultured cells: a user's guide

Echeverri, C. J., & Perrimon, N. (2006) · Nature Reviews Genetics

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 380

Functional genomics reveals genes involved in protein secretion and Golgi organization

Bard, F., Casano, L., Mallabiabarrena, A., Wallace, E., Saito, K., Kitayama, H., Guizzunti, G., Hu, Y., Wendler, F., DasGupta, R., et al. (2006) · Nature

Cellular transport and secretionFungal and yeast genetics research

Cited by 372

Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

He, L., Si, G., Huang, J., Samuel, A. D. T., & Perrimon, N. (2018) · Nature

Cellular Mechanics and InteractionsIon Channels and Receptors

Cited by 348

The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.

Rutledge, B. J., Zhang, K., Bier, E., Jan, Y. N., & Perrimon, N. (1992) · Genes & Development

Developmental Biology and Gene RegulationAxon Guidance and Neuronal Signaling

Cited by 274

The JAK/STAT Pathway in Model Organisms

Hou, S. X., Zheng, Z., Chen, X., & Perrimon, N. (2002) · Developmental Cell

Cytokine Signaling Pathways and InteractionsDevelopmental Biology and Gene Regulation

Cited by 251

The influence of skeletal muscle on systemic aging and lifespan

Demontis, F., Piccirillo, R., Goldberg, A. L., & Perrimon, N. (2013) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsMuscle Physiology and Disorders

Cited by 238

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

Demontis, F., Piccirillo, R., Goldberg, A. L., & Perrimon, N. (2013) · Disease Models & Mechanisms

Muscle Physiology and DisordersGenetics, Aging, and Longevity in Model Organisms

Cited by 238

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms

Shulman, J. M., Imboywa, S., Giagtzoglou, N., Powers, M. P., Hu, Y., Devenport, D., Chipendo, P., Chibnik, L. B., Diamond, A., Perrimon, N., et al. (2014) · Human Molecular Genetics

Alzheimer's disease research and treatmentsNeurobiology and Insect Physiology Research

Cited by 167

A Genomewide RNA Interference Screen for Modifiers of Aggregates Formation by Mutant Huntingtin in Drosophila

Zhang, S., Binari, R., Zhou, R., & Perrimon, N. (2010) · Genetics

Genetic Neurodegenerative DiseasesGenetics and Neurodevelopmental Disorders

Cited by 160

A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila

Okamoto, N., Viswanatha, R., Bittar, R., Li, Z., Haga-Yamanaka, S., Perrimon, N., & Yamanaka, N. (2018) · Developmental Cell

Drug Transport and Resistance MechanismsEstrogen and related hormone effects

Cited by 144

Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein

Mathew, D., Gramates, L. S., Packard, M., Thomas, U., Bilder, D., Perrimon, N., Gorczyca, M., & Budnik, V. (2002) · Current Biology

Neuroscience and Neuropharmacology ResearchNeurobiology and Insect Physiology Research

Cited by 134

The Nonreceptor Protein Tyrosine Phosphatase Corkscrew Functions in Multiple Receptor Tyrosine Kinase Pathways inDrosophila

Perkins, L. A., Johnson, M. R., Melnick, M. B., & Perrimon, N. (1996) · Developmental Biology

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 114

Conserved regulators of nucleolar size revealed by global phenotypic analyses

Neumüller, R. A., Gross, T., Samsonova, A. A., Vinayagam, A., Buckner, M., Founk, K., Hu, Y., Sharifpoor, S., Rosebrock, A. P., Andrews, B., et al. (2013) · Science Signaling

Nuclear Structure and FunctionGenomics and Chromatin Dynamics

Cited by 87

Collective nomenclature for LAP proteins

Bilder, D., Birnbaum, D., Borg, J.-P., Bryant, P., Huigbretse, J., Jansen, E., Kennedy, M. B., Labouesse, M., Legouis, R., Mechler, B., et al. (2000) · Nature Cell Biology

Developmental Biology and Gene RegulationProtein Kinase Regulation and GTPase Signaling

Cited by 81

Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells

Viswanatha, R., Li, Z., Hu, Y., & Perrimon, N. (2018) · eLife

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 79

Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation

Chung, H.-L., Ye, Q., Park, Y.-J., Zuo, Z., Mok, J.-W., Kanca, O., Tattikota, S. G., Lu, S., Perrimon, N., Lee, H. K., et al. (2023) · Cell Metabolism

Sphingolipid Metabolism and SignalingMultiple Sclerosis Research Studies

Cited by 70

Comparing CRISPR and RNAi-based screening technologies

Housden, B. E., & Perrimon, N. (2016) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 58

Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci

Marconcini, M., Cruchet, S., Goswami, S., Viswanatha, R., Butnaru, M., De, J., Roselli, C., Hadjieconomou, D., Perrimon, N., Mohr, S. E., et al. (2026) · eLife

Evolution and Genetic DynamicsInsect Resistance and Genetics

Cited by 2