Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood

Ronn, T.; Volkov, P.; Gillberg, L.; Kokosar, M.; Perfilyev, A.; Jacobsen, A. L.; Jorgensen, S. W.; Brons, C.; Jansson, P.-A.; Eriksson, K.-F.; Pedersen, O.; Hansen, T.; Groop, L.; Stener-Victorin, E.; Vaag, A.; Nilsson, E.; Ling, C.

doi:10.1093/hmg/ddv124

Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood

Increased age, BMI and HbA1c levels are risk factors for several non-communicable diseases. However, the impact of these factors on the genome-wide DNA methylation pattern in human adipose tissue remains unknown. We analyzed the DNA methylation of ∼480 000 sites in human adipose tissue from 96 ma…