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PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease
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“Another recent study demonstrated a functional link between CLEC16A and disrupted mitophagy in murine splenic immune cells and showed that incomplete mitophagy predisposes clec16a knockout mice to a cascade of altered immune signaling functions resulting in pathogenic inflammation [321,322].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [322]
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Citations
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“After dissipation of mitochondrial membrane potential (ΔΨm), the autophosphorylation of PINK1 is essential for its activation, promoting the recruitment of PARK2 to the mitochondria and its phosphorylation at Ser65 as an initial step of mitophagy (19,20).”
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Cited by
Sorted by citations
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationEmerging roles of oxidative stress in brain aging and Alzheimer's disease
Ionescu-Tucker, A., & Cotman, C. W. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.07.014 · Cited by 737
Mitophagy in Alzheimer’s disease: Molecular defects and therapeutic approaches
Mary, A., Eysert, F., Checler, F., & Chami, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01631-6 · Cited by 244
Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer’s Disease
McDaid, J., Mustaly-Kalimi, S., & Stutzmann, G. E. (2020) · Cells · doi:10.3390/cells9122655 · Cited by 73
Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases
Li, X., Huang, L., Lan, J., Feng, X., Li, P., Wu, L., & Peng, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105240 · Cited by 57
Metadata
- Authors
- Martín-Maestro, P., Gargini, R., Perry, G., Avila, J., & García-Escudero, V.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-12-31
- Volume
- 25
- Issue
- 4
- Pages
- 792-806
- ISSN
- 0964-6906
- 1460-2083
- Cited by
- 184
- References
- 10
- Language
- en
- Funders
- Ministerio de Economía y Competitividad (24841, BES-2012-055068)
- National Institute on Minority Health and Health Disparities (G12-MD007591)
- National Institutes of Health
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