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Cited by 566

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects

de Lamirande, E., Gagnon, C.·1995·Human Reproduction
DOI 10.1093/humrep/10.suppl_1.15
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Abstract

Reactive oxygen species (ROS) have beneficial or detrimental effects on sperm functions depending on the nature and the concentration of the ROS involved, as well as the moment and the location of exposure. Excessive generation of ROS in semen, mainly by neutrophils but also by abnormal spermatozoa, could be a cause for infertility. Hydrogen peroxide is the primary toxic ROS for human spermatozoa. Low concentrations of this ROS do not affect sperm viability but cause sperm immobilization mostly via depletion of intracellular ATP and the subsequent decrease in the phosphorylation of axonemal proteins. High concentrations of hydrogen peroxide induce lipid peroxidation and result in cell death. On the other hand, the superoxide anion appears to play a major role in the development of hyperactivation and capacitation. The observations that: (i) exogenously generated superoxide anions induce hyperactivation and capacitation; (ii) capacitating spermatozoa themselves produce elevated concentrations of superoxide anion over prolonged periods of time; and (iii) removal of this ROS by superoxide dismutase prevents sperm hyperactivation and capacitation induced by various biological fluids, stress the importance of the superoxide anion in these processes.

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Metadata

Authors
de Lamirande, E., & Gagnon, C.
Venue
Human Reproduction
Publisher
Oxford University Press (OUP)
Published
1995-10-01
Volume
10
Issue
suppl 1
Pages
15-21
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
DOI
10.1093/humrep/10.suppl_1.15
OpenAlex
W2115794619
Cited by
566
References
27
FWCI
7.20
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. https://app.cochat.ai/papers/10.1093/humrep/10.suppl_1.15
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de Lamirande, E., & Gagnon, C. (1995). Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. Human Reproduction. https://doi.org/10.1093/humrep/10.suppl_1.15

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.