The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Significance of Reactive Oxygen Species and Antioxidants in Defining the Efficacy of Sperm Preparation Techniques
Open accessAbstract
The mechanisms responsible for mediating the influence of sperm preparation protocols on human sperm function have been investigated. Techniques that involved the separation of motile spermatozoa prior to centrifugation were found to yield sperm suspensions of highest quality. If the spermatozoa were centrifuged prior to isolation of the motile cells, sperm function was impaired. The detrimental effects of centrifugation were associated with a sudden burst of reactive oxygen species production by a discrete subpopulation of cells (characterized by significantly diminished motility and fertilizing capacity) that could be separated from normal functional spermatozoa on Percoll gradients. If unfractionated sperm suspensions were subjected to centrifugation, the reactive oxygen species generated by this subpopulation impaired the functional competence of normal spermatozoa in the same suspension. Assessment of the ability of the antioxidants, butylated hydroxytoluene, and vitamin E, to curtail the peroxidative damage inflicted by such cells in response to centrifugation revealed a significant improvement of sperm function in the presence of vitamin E.
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Citations
Cites
Biemond, P., van Eijk, H. G., Swaak, A. J., & Koster, J. F. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111364 · Cited by 380
Cited by
EVENSON, D. P., LARSON, K. L., & JOST, L. K. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02599.x · Cited by 1,072
Henkel, R. R., & Schill, W.-B. (2003) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-1-108 · Cited by 538
ZINI, A., de LAMIRANDE, E., & GAGNON, C. (1993) · International Journal of Andrology · doi:10.1111/j.1365-2605.1993.tb01177.x · Cited by 396
Infections in the male genital tract and reactive oxygen species
Ochsendorf, F. (1999) · Human Reproduction Update · doi:10.1093/humupd/5.5.399 · Cited by 346
Plante, M., de Lamirande, E., & Gagnon, C. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56895-2 · Cited by 283
Metadata
- Authors
- AITKEN, R. J., & CLARKSON, J. S.
- Venue
- Journal of Andrology
- Publisher
- Wiley
- Published
- 1988-11-12
- Volume
- 9
- Issue
- 6
- Pages
- 367-376
- ISSN
- 0196-3635 (ISSN-L)
- 1939-4640
- OpenAlex
- W2128718884
- Cited by
- 779
- References
- 1
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- AITKEN, R. J., & CLARKSON, J. S. (1988). Significance of Reactive Oxygen Species and Antioxidants in Defining the Efficacy of Sperm Preparation Techniques. Journal of Andrology. https://doi.org/10.1002/j.1939-4640.1988.tb01067.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
