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Birth following vitrification of a small number of human oocytes: Case Report
Abstract
We report the birth of a healthy baby girl at 37 weeks gestation to a 47 year old recipient, after vitrification of mature oocytes from four in-vitro fertilization (IVF) patients. A total of 17 oocytes was vitrified in 1-2 microl of ethylene glycol (40%) and 0.6 mol/l sucrose (20.54%) in open pulled straws. Eleven oocytes survived after vitrification and five pronuclear zygotes were obtained after intracytoplasmic sperm injection (ICSI). Three embryos were transferred to three patients, two of whom were the original oocyte donors and pregnancy was not established. The third embryo was donated to a 47 year old infertile woman after preimplantation diagnosis had confirmed euploidy for chromosomes X, 13, 14, 15, 16, 18, 21 and 22. The successfully completed pregnancy is encouraging for further research to explore the potential benefits of vitrification for the cryopreservation of human oocytes, given the relatively low success of conventional freezing of human oocytes by slow cooling methods.
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Cited by
Highly efficient vitrification method for cryopreservation of human oocytes
Kuwayama, M., Vajta, G., Kato, O., & Leibo, S. P. (2005) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60837-1 · Cited by 1,254
Rienzi, L., Romano, S., Albricci, L., Maggiulli, R., Capalbo, A., Baroni, E., Colamaria, S., Sapienza, F., & Ubaldi, F. (2010) · Human Reproduction · doi:10.1093/humrep/dep346 · Cited by 490
Oocyte vitrification for fertility preservation for both medical and nonmedical reasons
Cobo, A., García-Velasco, J. A., Remohí, J., & Pellicer, A. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.02.006 · Cited by 165
Metadata
- Authors
- Kuleshova, L., Gianaroli, L., Magli, C., Ferraretti, A., & Trounson, A.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-12
- Volume
- 14
- Issue
- 12
- Pages
- 3077-3079
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2148462455
- Cited by
- 557
- References
- 0
- FWCI
- 14.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kuleshova, L., Gianaroli, L., Magli, C., Ferraretti, A., & Trounson, A. (1999). Birth following vitrification of a small number of human oocytes: Case Report. Human Reproduction. https://doi.org/10.1093/humrep/14.12.3077
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