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The role of trophoblast in the physiological change in decidual spiral arteries
Open accessAbstract
The remodelling of the maternal uterine spiral arteries during pregnancy, known as physiological change, is critical for the normal growth and development of the fetus. Controversy has surrounded the part played by fetal trophoblast in the transformation of these spiral arteries. To address this debate, a histological and immunochemical comparison of blood vessels from the implantation sites of human pregnancies of early gestation with uterine tissue where trophoblast was absent was performed. Results showed that true physiological change, with the features of medial necrosis and deposition of fibrinoid material, only occurred in the presence of trophoblast. In addition, it was found that subpopulations of trophoblast contribute differently in the process. Interstitial trophoblast-mediated destruction of the arterial media precedes replacement of the endothelial cells by endovascular trophoblast.
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Cited by
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Brosens, I., Pijnenborg, R., Vercruysse, L., & Romero, R. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.08.009 · Cited by 1,568
Onset of Maternal Arterial Blood Flow and Placental Oxidative Stress
Jauniaux, E., Watson, A. L., Hempstock, J., Bao, Y.-P., Skepper, J. N., & Burton, G. J. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64849-3 · Cited by 1,057
The Placenta: A Multifaceted, Transient Organ
Burton, G. J., & Fowden, A. L. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0066 · Cited by 833
Development of the human placenta
Turco, M. Y., & Moffett, A. (2019) · Development · doi:10.1242/dev.163428 · Cited by 698
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Burton, G. J., & Jauniaux, E. (2004) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2004.03.003 · Cited by 673
Metadata
- Authors
- Kam, E. P. Y., Gardner, L., Loke, Y. W., & King, A.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08
- Volume
- 14
- Issue
- 8
- Pages
- 2131-2138
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2153787928
- Cited by
- 279
- References
- 0
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kam, E. P. Y., Gardner, L., Loke, Y. W., & King, A. (1999). The role of trophoblast in the physiological change in decidual spiral arteries. Human Reproduction. https://doi.org/10.1093/humrep/14.8.2131
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
