The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Positive outcome after preimplantation diagnosis of aneuploidy in human embryos *
Abstract
usromosomal abnormalities are responsible for a great deal of embryo wastage, which is reflected, at least partially, in decreased implantation and increased miscarriage in older women. To address this problem the transfer of only chromosomally normal embryos previously selected by preimplantation genetic diagnosis (PGD) has been proposed. We designed a multi-centre in-vitro fertilization (IVF) study to compare controls and a test group that underwent embryo biopsy and PGD for aneuploidy. Patients were matched retrospectively, but blindly, for average maternal age, number of previous IVF cycles, duration of stimulation, oestradiol concentrations on day +1, and average mature follicles. All these parameters were similar in test and control groups. Only embryos classified as normal for those chromosomes were transferred after PGD. The results showed that the rates of fetal heart beat (FHB)/embryo transferred between the control and test groups were similar. However, spontaneous abortions, measured as FHB aborted/FHB detected, decreased after PGD (P < 0.05), and ongoing pregnancies and delivered babies increased (P < 0.05) in the PGD group of patients. Two conclusions were obtained: (i) PGD of aneuploidy reduced embryo loss after implantation; (ii) implantation rates were not significantly improved, but the proportion of ongoing and delivered babies was increased.
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Citations
Cites
Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy
Hassold, T., & Chiu, D. (1985) · Human Genetics · doi:10.1007/bf00389450 · Cited by 481
Cited by
Thornhill, A. R., deDie-Smulders, C. E., Geraedts, J. P., Harper, J. C., Harton, G. L., Lavery, S. A., Moutou, C., Robinson, M. D., Schmutzler, A. G., Scriven, P. N., et al. (2005) · Human Reproduction · doi:10.1093/humrep/deh579 · Cited by 455
Outcome of preimplantation genetic diagnosis of translocations
Munné, S., Sandalinas, M., Escudero, T., Fung, J., Gianaroli, L., & Cohen, J. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00495-7 · Cited by 361
Self-citationTreff, N. R., Su, J., Tao, X., Levy, B., & Scott, R. T. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.01.052 · Cited by 270
Self-citationPreimplantation genetic diagnosis at 20 years
Simpson, J. L. (2010) · Prenatal Diagnosis · doi:10.1002/pd.2552 · Cited by 117
A universal carrier test for the long tail of Mendelian disease
Srinivasan, B. S., Evans, E. A., Flannick, J., Patterson, A. S., Chang, C. C., Pham, T., Young, S., Kaushal, A., Lee, J., Jacobson, J. L., et al. (2010) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2010.05.012 · Cited by 105
Metadata
- Authors
- Munné, S., Magli, C., Cohen, J., Morton, P., Sadowy, S., Gianaroli, L., Tucker, M., Márquez, C., Sable, D., Ferraretti, A. P., Massey, J. B., & Scott, R.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-09
- Volume
- 14
- Issue
- 9
- Pages
- 2191-2199
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2160524881
- Cited by
- 395
- References
- 1
- FWCI
- 22.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Munné, S., Magli, C., Cohen, J., Morton, P., Sadowy, S., Gianaroli, L., Tucker, M., Márquez, C., Sable, D., Ferraretti, A. P., Massey, J. B., & Scott, R. (1999). Positive outcome after preimplantation diagnosis of aneuploidy in human embryos *. Human Reproduction. https://doi.org/10.1093/humrep/14.9.2191
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