Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy
Abstract
The effect of maternal age on the incidence of chromosomally normal spontaneous abortion and different categories of chromosome abnormality among all clinically recognized human pregnancies was evaluated. The results provide no evidence for a significant association of age with sex chromosome monosomy or polyploidy, but clearly demonstrate an effect of age on the frequency of trisomy and chromosomally normal spontaneous abortions. Estimated maternal age-specific rates of trisomy among all recognized pregnancies were calculated and suggest that a majority of oocytes of women aged 40 years and older may be aneuploid.
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Chromosomal abnormalities are found in 60% of miscarried tissue but less than 1% of live births, when pre-natal diagnosis is not used.
“Chromosomal abnormalities are found in 60% of miscarried tissue 47 but less than 1% of live births, when pre-natal diagnosis is not used. 48”
From Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss (2021) · cites this paper as [48]
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- Authors
- Hassold, T., & Chiu, D.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- ORCID
- Venue
- Human Genetics
- Published
- 1985-05
- Volume
- 70
- Issue
- 1
- Pages
- 11-17
- ISSN
- 0018-7348 (ISSN-L)
- 0340-6717
- 1432-1203
- OpenAlex
- W1966649193
- Cited by
- 481
- References
- 25
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 9 · 2023: 8 · 2022: 17 · 2021: 11 · 2020: 19 · 2019: 11 · 2018: 17 · 2017: 20 · 2016: 15 · 2015: 16 · 2014: 19 · 2013: 22 · 2012: 18
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-07879)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- maternal age, trisomy, numerical chromosomal abnormalities, miscarriage, oocyte aneuploidy, polyploidy, pregnancy incidence, age-specific rates
- MeSH terms
- Abortion, Spontaneous, Adolescent, Adult, Aneuploidy, Chromosome Aberrations, Female, Humans, Karyotyping, Maternal Age, Middle Aged, Pregnancy, Trisomy, Pregnancy, High-Risk, Chromosome Disorders
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