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Sperm chromatin structure assay parameters as predictors of failed pregnancy following assisted reproductive techniques
Abstract
The predictive value of sperm chromatin integrity for pregnancy outcome following in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) was studied in 24 men attending a university-based assisted reproductive techniques laboratory using the flow cytometric sperm chromatin structure assay (SCSA). The SCSA is a measure of the susceptibility of sperm DNA to low pH-induced denaturation in situ. The mean percentage of spermatozoa in the neat sample demonstrating DNA denaturation was significantly lower in the seven men that initiated a pregnancy (15.4 +/- 4.6, P = 0.01) than in the 14 men who did not initiate a pregnancy (31.1 +/- 3.2). No pregnancies resulted if > or =27% of the spermatozoa in the neat semen sample showed DNA denaturation. These data demonstrate that SCSA parameters are independent of conventional semen parameters. Furthermore, the SCSA may allow physicians to identify male patients for whom IVF and ICSI will be unlikely to result in pregnancy initiation.
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Citations
Cited by
EVENSON, D. P., LARSON, K. L., & JOST, L. K. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02599.x · Cited by 1,072
Self-citationSaleh, R. A., Agarwal, A., Nada, E. A., El-Tonsy, M. H., Sharma, R. K., Meyer, A., Nelson, D. R., & Thomas, A. J. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00337-6 · Cited by 466
Ollero, M., Gil-Guzman, E., Lopez, M. C., Sharma, R. K., Agarwal, A., Larson, K., Evenson, D., Thomas, A. J., & Alvarez, J. G. (2001) · Human Reproduction · doi:10.1093/humrep/16.9.1912 · Cited by 392
Self-citationBartoov, B., Berkovitz, A., Eltes, F., Kogosovsky, A., Yagoda, A., Lederman, H., Artzi, S., Gross, M., & Barak, Y. (2003) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.05.016 · Cited by 375
Sperm chromatin structure and male fertility: biological and clinical aspects
Erenpreiss, J., Spano, M., Erenpreisa, J., Bungum, M., & Giwercman, A. (2006) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2006.00112.x · Cited by 304
Metadata
- Authors
- Larson, K. L.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-08-01
- Volume
- 15
- Issue
- 8
- Pages
- 1717-1722
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2162767305
- Cited by
- 480
- References
- 0
- FWCI
- 16.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Larson, K. L. (2000). Sperm chromatin structure assay parameters as predictors of failed pregnancy following assisted reproductive techniques. Human Reproduction. https://doi.org/10.1093/humrep/15.8.1717
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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