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Cited by 1,072Sperm and Testicular FunctionReproductive biology and impacts on aquatic speciesMale Reproductive Health Studies

Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques

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EVENSON, DONALD P., LARSON, KJERSTEN L., JOST, LORNA K.·2002·Journal of Andrology
DOI 10.1002/j.1939-4640.2002.tb02599.x
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Abstract

The Sperm Chromatin Structure Assay (SCSA) was first described in the December 5, 1980 issue of Science (Evenson et al, 1980a).The data described in that article showed a significant difference between proven fertile and subfertility or infertility in men and bulls and the susceptibility to denaturation of their sperm nuclear DNA.A subsequent study (Evenson et al, 1984) described SCSA data obtained from men with testicular cancer.The data were heterogeneous, and begged the question, what was SCSA measuring?Great effort has been spent over the past 15 years on animal model systems, mostly related to dose-response toxicology experiments and large animal fertility trials.The results from these studies showed that SCSA was highly dose-responsive to toxicants, highly repeatable, and provided meaningful biological information on sperm nuclear DNA defects.The extensive data from nonhumans (Evenson et al, 1985(Evenson et al, , 1986(Evenson et al, , 1989a(Evenson et al, ,b, 1993a(Evenson et al, ,b,c, 1994(Evenson et al, , 1995b;; Ballachey et

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Cited by

Sorted by citations

Authors
EVENSON, D. P., LARSON, K. L., & JOST, L. K.
Affiliations
South Dakota State University (US)
Corresponding author
EVENSON, DONALD P.
ORCID
EVENSON, DONALD P.
Venue
Journal of Andrology
Publisher
Wiley
Published
2002-01-02
Volume
23
Issue
1
Pages
25-43
ISSN
  • 0196-3635 (ISSN-L)
  • 1939-4640
DOI
10.1002/j.1939-4640.2002.tb02599.x
OpenAlex
W1532901402
Cited by
1,072
References
158
Citations by year
2026: 15 · 2025: 21 · 2024: 18 · 2023: 25 · 2022: 36 · 2021: 59 · 2020: 35 · 2019: 50 · 2018: 49 · 2017: 51 · 2016: 42 · 2015: 53 · 2014: 53 · 2013: 68 · 2012: 61
FWCI
38.26
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4018 d)
Locations
  • Journal of Andrology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (9452894, 9720642)
  • U.S. Environmental Protection Agency
  • South Dakota Agricultural Experiment Station
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
  • Health Sciences › Health Professions › General Health Professions › Male Reproductive Health Studies
Keywords
sperm chromatin structure assay, sperm DNA fragmentation, male infertility, testicular cancer
MeSH terms
Chromatin, Humans, Infertility, Male, Male, Spermatozoa, DNA Fragmentation

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