The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage
Abstract
Recurrent miscarriage (RM; > or =3 consecutive early pregnancy losses) affects around 1% of fertile couples. Parental chromosomal anomalies, maternal thrombophilic disorders and structural uterine anomalies have been directly associated with recurrent miscarriage; however, in the vast majority of cases the pathophysiology remains unknown. We have updated the ESHRE Special Interest Group for Early Pregnancy (SIGEP) protocol for the investigation and medical management of RM. Based on the data of recently published large randomized controlled trials (RCTs) and meta-analyses, we recommend that basic investigations of a couple presenting with recurrent miscarriage should include obstetric and family history, age, BMI and exposure to toxins, full blood count, antiphospholipid antibodies (lupus anticoagulant and anticardiolipin antibodies), parental karyotype, pelvic ultrasound and/or hysterosalpingogram. Other investigations should be limited to particular cases and/or used within research programmes. Tender loving care and health advice are the only interventions that do not require more RCTs. All other proposed therapies, which require more investigations, are of no proven benefit or are associated with more harm than good.
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Citations
Cites
Maternal age and fetal loss: population based register linkage study
Andersen, A.-M. N. (2000) · BMJ · doi:10.1136/bmj.320.7251.1708 · Cited by 1,690 · cited 1×
“The risk of recurrence increases with the maternal age and number of successive losses (Brigham et al., 1999; Andersen et al., 2000).”
BackgroundGreer, I. A., & Nelson-Piercy, C. (2005) · Blood · doi:10.1182/blood-2005-02-0626 · Cited by 797
Clark, A. M., Thornley, B., Tomlinson, L., Galletley, C., & Norman, R. J. (1998) · Human Reproduction · doi:10.1093/humrep/13.6.1502 · Cited by 789
Embryonic karyotype of abortuses in relation to the number of previous miscarriages
Ogasawara, M., Aoki, K., Okada, S., & Suzumori, K. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00495-1 · Cited by 604
Recurrent miscarriage I: definition and epidemiology
Stirrat, G. M. (1990) · The Lancet · doi:10.1016/0140-6736(90)92159-f · Cited by 600
Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant
Empson, M. B., Lassere, M., Craig, J. C., & Scott, J. R. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002859.pub2 · Cited by 486
Immunotherapy for recurrent miscarriage
Wong, L. F., Porter, T. F., & Scott, J. R. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000112.pub3 · Cited by 348
Cytogenetic studies in couples experiencing repeated pregnancy losses
Braekeleer, M. D., & Dao, T.-N. (1990) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137135 · Cited by 272
Carlin, A. J. (2004) · Human Reproduction · doi:10.1093/humrep/deh115 · Cited by 99
Cited by
Recurrent pregnancy loss: current perspectives
El Hachem, H., Crepaux, V., May-Panloup, P., Descamps, P., Legendre, G., & Bouet, P.-E. (2017) · International Journal of Women's Health · doi:10.2147/ijwh.s100817 · Cited by 462
Kolte, A. M., Bernardi, L. A., Christiansen, O. B., Quenby, S., Farquharson, R. G., Goddijn, M., Stephenson, M. D., & on behalf of the ESHRE Special Interest Group, E. P. (2015) · Human Reproduction · doi:10.1093/humrep/deu299 · Cited by 386
van den Berg, M. M. J., van Maarle, M. C., van Wely, M., & Goddijn, M. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.07.001 · Cited by 282
Liu, Y., Chen, X., Huang, J., Wang, C.-C., Yu, M.-Y., Laird, S., & Li, T.-C. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.01.022 · Cited by 215
de Jong, P. G., Kaandorp, S., Di Nisio, M., Goddijn, M., & Middeldorp, S. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004734.pub4 · Cited by 204
Metadata
- Authors
- Jauniaux, E.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06-03
- Volume
- 21
- Issue
- 9
- Pages
- 2216-2222
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2153113454
- Cited by
- 520
- References
- 9
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jauniaux, E. (2006). Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Human Reproduction. https://doi.org/10.1093/humrep/del150
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
