The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Recurrent pregnancy loss: current perspectives
Open accessAbstract
Recurrent pregnancy loss is an important reproductive health issue, affecting 2%-5% of couples. Common established causes include uterine anomalies, antiphospholipid syndrome, hormonal and metabolic disorders, and cytogenetic abnormalities. Other etiologies have been proposed but are still considered controversial, such as chronic endometritis, inherited thrombophilias, luteal phase deficiency, and high sperm DNA fragmentation levels. Over the years, evidence-based treatments such as surgical correction of uterine anomalies or aspirin and heparin for antiphospholipid syndrome have improved the outcomes for couples with recurrent pregnancy loss. However, almost half of the cases remain unexplained and are empirically treated using progesterone supplementation, anticoagulation, and/or immunomodulatory treatments. Regardless of the cause, the long-term prognosis of couples with recurrent pregnancy loss is good, and most eventually achieve a healthy live birth. However, multiple pregnancy losses can have a significant psychological toll on affected couples, and many efforts are being made to improve treatments and decrease the time needed to achieve a successful pregnancy. This article reviews the established and controversial etiologies, and the recommended therapeutic strategies, with a special focus on unexplained recurrent pregnancy losses and the empiric treatments used nowadays. It also discusses the current role of preimplantation genetic testing in the management of recurrent pregnancy loss.
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MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203
Incidence of early loss of pregnancy
Wilcox, A. J., Weinberg, C. R., O'Connor, J. F., Baird, D. D., Schlatterer, J. P., Canfield, R. E., Armstrong, E. G., & Nisula, B. C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807283190401 · Cited by 2,354
The Practice Committee of the American Society for Reproductive Medicine
Birmingham, A. (2006) · Cited by 1,925
De Groot, L., Abalovich, M., Alexander, E. K., Amino, N., Barbour, L., Cobin, R. H., Eastman, C. J., Lazarus, J. H., Luton, D., Mandel, S. J., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2803 · Cited by 1,866
Zegers-Hochschild, F., Adamson, G. D., de Mouzon, J., Ishihara, O., Mansour, R., Nygren, K., Sullivan, E., & Vanderpoel, S. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.09.009 · Cited by 1,835
Munro, M. G., Critchley, H. O. D., Broder, M. S., Fraser, I. S., & for the FIGO Working Group on Menstrual Disorders (2011) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2010.11.011 · Cited by 1,685
Evaluation and treatment of recurrent pregnancy loss: a committee opinion
(2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.06.048 · Cited by 1,308
Clinical implications of uterine malformations and hysteroscopic treatment results
Grimbizis, G. F. (2001) · Human Reproduction Update · doi:10.1093/humupd/7.2.161 · Cited by 949
Abalovich, M., Amino, N., Barbour, L. A., Cobin, R. H., De Groot, L. J., Glinoer, D., Mandel, S. J., & Stagnaro-Green, A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0141 · Cited by 931
Cited by
Iews, M., Tan, J., Taskin, O., Alfaraj, S., AbdelHafez, F. F., Abdellah, A. H., & Bedaiwy, M. A. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.03.005 · Cited by 56
Kent-Nye, F. E., Sheen, K. S., Burgess, K., Oza, M., Magee, L. A., Jurković, D., & Silverio, S. A. (2025) · BMC Public Health · doi:10.1186/s12889-024-20882-2 · Cited by 4
“There is considerable debate about what constitutes ‘recurrent’ early pregnancy loss [rEPL], particularly with regards to the number of losses required and whether these need to be consecutive [1–4].”
Metadata
- Authors
- El Hachem, H., Crepaux, V., May-Panloup, P., Descamps, P., Legendre, G., & Bouet, P.-E.
- Venue
- International Journal of Women's Health
- Publisher
- Informa UK Limited
- Published
- 2017-05
- Volume
- Volume 9
- Pages
- 331-345
- ISSN
- 1179-1411 (ISSN-L)
- OpenAlex
- W2614898738
- Cited by
- 462
- References
- 169
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- gold
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- El Hachem, H., Crepaux, V., May-Panloup, P., Descamps, P., Legendre, G., & Bouet, P.-E. (2017). Recurrent pregnancy loss: current perspectives. International Journal of Women's Health. https://doi.org/10.2147/ijwh.s100817
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
