The DOI matches its Crossref record; 24 of the 25 references it cites were found in a registry or an index.
Anti-Müllerian hormone inhibits initiation of growth of human primordial ovarian follicles in vitro
Abstract
BACKGROUND: Anti-Müllerian hormone (AMH) inhibits the initiation of the development and early growth of mouse ovarian follicles. Furthermore, the ovarian follicle pool diminishes prematurely in AMH-knockout mice. In this study, we examined whether AMH plays a similar role in humans, controlling ovarian follicle growth. METHODS: Human ovarian cortical tissue biopsy specimens were cut into small pieces and cultured for 7 days in medium containing rat recombinant AMH at 0, 10, 30 or 100 ng/ml. The developmental stages and viability of the follicles were evaluated from histological sections. RESULTS: Similar to previous studies, significant initiation of follicle growth was observed in almost all culture media, as demonstrated by a significantly smaller proportion of primordial follicles (14-26%) compared with non-cultured control tissue (56%). The exception was tissue in medium supplemented with AMH at 100 ng/ml. Here, the proportion of primordial follicles was not significantly different from that in non-cultured tissue; furthermore, it was significantly greater than that in vehicle control cultures and cultures containing AMH at 10 ng/ml, indicating the inhibition of growth initiation. Viability was unaffected by the presence of AMH when compared with tissues in control media. CONCLUSIONS: Recombinant AMH at a concentration of 100 ng/ml has an inhibitory effect on early human ovarian follicular development in vitro, suppressing the initiation of primordial follicle growth.
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“In contrast to mice where AMH inhibits preantral follicle growth and antral follicle maturation, AMH appears to promote growth of preantral follicles to the antral stage in nonhuman primate (NHP) ovaries [11, 12].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [11]
Citations
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The physiology and clinical utility of anti-Müllerian hormone in women
Dewailly, D., Andersen, C. Y., Balen, A. H., Broekmans, F. J., Dilaver, N., Fanchin, R. R. F., Griesinger, G., Kelsey, T., Marca, A. L., Lambalk, C. B., et al. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt062 · Cited by 1,056
Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART)
Marca, A. L., Sighinolfi, G., Radi, D., Argento, C., Baraldi, E., Artenisio, A. C., Stabile, G., & Volpe, A. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmp036 · Cited by 955
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Metadata
- Authors
- Carlsson, I. B.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Carlsson, I.B.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06-03
- Volume
- 21
- Issue
- 9
- Pages
- 2223-2227
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2131854962
- Cited by
- 294
- References
- 25
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 10 · 2023: 15 · 2022: 9 · 2021: 26 · 2020: 17 · 2019: 23 · 2018: 14 · 2017: 13 · 2016: 12 · 2015: 17 · 2014: 21 · 2013: 16 · 2012: 16
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- anti-Müllerian hormone, primordial follicles, ovarian follicle development, folliculogenesis, ovarian cortical tissue, follicle viability, human ovary
- MeSH terms
- Adult, Animals, Female, Glycoproteins, Ovarian Follicle, Humans, Ovary, Testicular Hormones, Mice, Knockout, Cell Culture Techniques, Cell Proliferation, Mice, Rats, Anti-Mullerian Hormone
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