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Cited by 43Reproductive System and PregnancyReproductive Health and ContraceptionPregnancy and Medication Impact

Risk factors of early spontaneous abortions among Japanese: a matched case-control study

Baba, S., Noda, H., Nakayama, M., Waguri, M., Mitsuda, N., Iso, H.·2011·Human Reproduction
DOI 10.1093/humrep/deq343
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Abstract

BACKGROUND: No epidemiological studies have examined risk factors for early spontaneous abortions among Japanese women. In this matched case-control study, we investigated the associations of reproductive, physical, and lifestyle characteristics of women and their husbands with early spontaneous abortion <12 weeks of gestation. METHODS: Information was collected through medical records for 430 cases of early spontaneous abortion and 860 controls of term delivery. Two controls were individual-matched to one case according to maternal age (± 3 years) and calendar year of events (either early spontaneous abortion or delivery). Multivariable conditional odds ratios (ORs) and 95% confidence interval (CI) were calculated with conditional logistic-regression. RESULTS: The risk of early spontaneous abortions was higher for women with a past history of early spontaneous abortions; OR was 1.98 (95% CI: 1.35, 2.89) for one previous spontaneous abortion, 2.36 (95% CI: 1.47, 3.79) for two, and 8.73 (95% CI: 5.22, 14.62) for three or more. Other factors also influence risk; an OR of 2.39 (95% CI: 1.26, 4.25) was found for women who smoked, and 1.65 (95%CI: 1.17, 2.35) for women working outside the home. CONCLUSIONS: Our finding suggests that for Japanese women, smoking and working may be important public health issue targets for the prevention of early spontaneous abortions.

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  • Endometrium transforms into decidua during implantation to accommodate the invading placenta.

    “Endometrium transforms into decidua during implantation to accommodate the invading placenta. 51”

    From Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss (2021) · cites this paper as [51]

    The Discussion mentions the endometrium only as a possible site of obesity-related effects on miscarriage; it does not describe its transformation into decidua or its role in accommodating the placenta. Searches for the claimed wording and for decidua, implantation, and placenta found no passage addressing that process in our copy. (LLM, conf=0.76)

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Research works printed but not linked: 1

  1. Cunningham F, Leveno K, Bloom S, Hauth J. Williams Obstetrics, 23rd edn. New York, USA: McGraw-Hill, 2010.

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Authors
Baba, S., Noda, H., Nakayama, M., Waguri, M., Mitsuda, N., & Iso, H.
Affiliations
  • Osaka Women's and Children's Hospital (JP)
  • Osaka University Hospital (JP)
  • The University of Osaka (JP)
Corresponding author
Iso, H.
ORCID
Venue
Human Reproduction
Publisher
Oxford University Press (OUP)
Published
2010-12-14
Volume
26
Issue
2
Pages
466-472
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
DOI
10.1093/humrep/deq343
OpenAlex
W2146833092
Cited by
43
References
28
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 9 · 2013: 1 · 2012: 3
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction (publishedVersion)
  • PubMed (publishedVersion)
  • OUKA (Osaka University Knowledge Archive) (Osaka University) (submittedVersion)
Funders
Japan Society for the Promotion of Science (21890218)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
early spontaneous abortion, miscarriage, risk factors, Japanese women, smoking, maternal employment, lifestyle factors, reproductive traits
MeSH terms
Abortion, Spontaneous, Abortion, Induced, Adolescent, Adult, Female, Humans, Japan, Maternal Age, Middle Aged, Pregnancy, Pregnancy Trimester, First, Risk Factors, Smoking, Women, Working, Case-Control Studies

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