Placental weight in singleton pregnancies with and without assisted reproductive technology: a population study of 536 567 pregnancies
Abstract
BACKGROUND: Pregnancies conceived by assisted reproductive technology (ART) are at increased risk of adverse outcomes. Previous studies have suggested increased placental weight and increased placental weight/birthweight ratio in pregnancies associated with adverse outcomes. We therefore studied the association of ART with placental weight and placental weight/birthweight ratio. METHODS: We included all singleton births in the Medical Birth Registry of Norway during the period 1999-2008 (n = 536 567, including 8259 after ART). We divided placental weight and placental weight/birthweight ratio into quartiles, and calculated the proportions of ART and spontaneous pregnancies in the lowest and the highest quartile by length of gestation. Thereafter, we estimated crude and adjusted odds ratios (ORs) for being in each quartile of placental weight for ART pregnancies with spontaneous pregnancies as the reference. The analyses were repeated with ART pregnancies subgrouped into IVF or ICSI. RESULTS: Mean placental weight was 678.9 g in pregnancies conceived by ART, and 673.0 g in pregnancies after spontaneous conception. ART pregnancies were overrepresented in the highest quartile of placental weight and underrepresented in the highest quartile of birthweight, independent of length of gestation at delivery. Thus, placental weight/birthweight ratio was higher in ART pregnancies. For ART pregnancies, the OR for being in the highest quartile of placental weight was 1.37 (95% confidence interval 1.30-1.45) after adjustment for length of gestation, offspring birthweight, parity, fetal sex, maternal age, pre-eclampsia and diabetes. There was no difference in placental weight/birthweight ratio between IVF and ICSI pregnancies. CONCLUSIONS: We found larger placentas and a higher placental weight/birthweight ratio among pregnancies conceived by ART compared with spontaneous pregnancies, and the difference was independent of length of gestation at delivery and ART method.
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A large study of over 500,000 births showed that placentas arising from assisted reproduction techniques are heavier than those from natural conceptions.
“A large study of over 500,000 births showed that placentas arising from ART are heavier than those from natural conceptions (233).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [233]
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Placental Origins of Chronic Disease
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- Authors
- Haavaldsen, C., Tanbo, T., & Eskild, A.
- Affiliations
- University of Oslo (NO)
- Oslo University Hospital (NO)
- Norwegian Institute of Public Health (NO)
- Corresponding author
- Haavaldsen, C.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-12-19
- Volume
- 27
- Issue
- 2
- Pages
- 576-582
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2111806142
- Cited by
- 120
- References
- 43
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 10 · 2020: 9 · 2019: 4 · 2018: 12 · 2017: 3 · 2016: 9 · 2015: 11 · 2014: 10 · 2013: 11 · 2012: 2
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- placental weight, assisted reproduction, in vitro fertilization, intracytoplasmic sperm injection, singleton pregnancy, spontaneous conception, birth weight, gestation length, preeclampsia, maternal diabetes, adverse pregnancy outcomes
- MeSH terms
- Algorithms, Birth Weight, Family Characteristics, Female, Fertilization in Vitro, Humans, Infertility, Infertility, Female, Infertility, Male, Male, Norway, Organ Size, Placenta, Placenta Diseases, Placentation, Pregnancy, Registries, Sperm Injections, Intracytoplasmic, Reproductive Techniques, Assisted
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