The DOI matches its Crossref record; 43 of the 45 references it cites were found in a registry or an index.
Uterine peristalsis during the follicular phase of the menstrual cycle: effects of oestrogen, antioestrogen and oxytocin
Abstract
Uterine peristalsis, directing sustained and rapid sperm transport from the external cervical os or the cervical crypts to the isthmic part of the tube ipsilateral to the dominant follicle, changes in direction and frequency during the menstrual cycle, with lowest activity during menstruation and highest activity at mid cycle. It was therefore suggested that uterine peristalsis is under the control of the dominant follicle with the additional involvement of oxytocin. To test this hypothesis, vaginal sonography of uterine peristalsis was performed in the early, mid and late proliferative phases, respectively, of cycles of women treated with oestradiol valerate and with human menopausal gonadotrophin following pituitary downregulation, with clomiphene citrate and with intravenous oxytocin, respectively. Administration of oestradiol valerate resulted in oestradiol serum concentrations comparable with the normal cycle with a simulation of the normal frequency of peristaltic contractions. Elevated oestradiol concentrations and bolus injections of oxytocin resulted in a significant increase in the frequency of peristaltic contractions in the early and mid follicular phases, respectively. Chlomiphene tended, though insignificantly so, to suppress the frequency of peristaltic waves in the presence of elevated oestradiol concentrations. In the late follicular phase of the cycle extremely elevated oestradiol concentrations as well as the injection of oxytocin resulted only in an insignificant further increase of peristaltic frequency. In the normal cycles, as well as during extremely elevated oestradiol concentrations and following oxytocin administration, the peristaltic contractions were always confined to the subendometrial layer of the muscular wall. The results and the review of literature indicate that uterine peristalsis during the follicular phase of the menstrual cycle is controlled by oestradiol released from the dominant follicle with the probable involvement of oxytocin, which is presumably stimulated together with its receptor within the endometrial-subendometrial unit and therefore acting in an autocrine/paracrine fashion. Since unphysiological stimulation with oestradiol and oxytocin did not significantly increase the frequency of uterine peristalsis in the late follicular phase of the cycle it is assumed that normal preovulatory frequency of uterine peristalsis is at a level which cannot be significantly surpassed due to phenomena of refractoriness of the system.
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“The intensity of uterine peristaltic activity in women with endometriosis resembles that of women during controlled ovarian hyperstimulation although the peripheral estradiol levels are within the normal range [4, 29, 44].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [44]
In the citing paper
“Focal estrogen production might reach a tissue level that, in a paracrine fashion, acts upon the archimyometrium and increases uterine peristaltic activity presumably mediated by endometrial oxytocin and its receptor [44, 68, 69].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [44]
Citations
Cites
Lessey, B. A., Killam, A. P., METZGER, D. A., Haney, A. F., Greene, G. L., & McCarty, K. S. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-2-334 · Cited by 647
Endocrine control of parturition
Thorburn, G. D., & Challis, J. R. G. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.4.863 · Cited by 426
Kunz, G., Beil, D., Deininger, H., Wildt, L., & Leyendecker, G. (1996) · Human Reproduction · doi:10.1093/humrep/11.3.627 · Cited by 408
Self-citationLeyendecker, G., Kunz, G., Wildt, L., Beil, D., & Deininger, H. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019435 · Cited by 307
Self-citationLyons, E. A., Taylor, P. J., Zheng, X. H., Ballard, G., Levi, C. S., & Kredentser, J. V. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54246-0 · Cited by 272
Contractions of the inner third of the myometrium
de Vries, K., Lyons, E. A., Ballard, G., Levi, C. S., & Lindsay, D. J. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90983-e · Cited by 243
Estrogen and Antiestrogen Action in Reproductive Tissues and Tumors
Katzenellenbogen, B. S., Bhakoo, H. S., Ferguson, E. R., Lan, N. C., Tatee, T., Tsai, T. L. S., & Katzenellenbogen, J. A. (1979) · Elsevier eBooks · doi:10.1016/b978-0-12-571135-7.50010-2 · Cited by 191
Snijders, M. P. M. L., de Goeij, A. F. P. M., Baerts, M. D.-T., Rousch, M., Koudstaal, J., & Bosman, F. T. (1992) · Reproduction · doi:10.1530/jrf.0.0940363 · Cited by 188
Identification of nitric oxide synthase in human uterus
Telfer, J. F., Lyall, F., Norman, J. E., & Cameron, I. (1995) · Human Reproduction · doi:10.1093/humrep/10.1.19 · Cited by 154
Cited by
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The pathophysiology of endometriosis and adenomyosis, tissue injury and repair
Leyendecker, G., Wildt, L., & Mall, G. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1191-0 · Cited by 418
Kunz, G., Beil, D., Huppert, P., Noe, M., Kissler, S., & Leyendecker, G. (2005) · Human Reproduction · doi:10.1093/humrep/dei021 · Cited by 377
Self-citationPhysiological pathways and molecular mechanisms regulating uterine contractility
Aguilar, H. N., & Mitchell, B. F. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq016 · Cited by 337
Adenomyosis: Mechanisms and Pathogenesis
Zhai, J., Vannuccini, S., Petraglia, F., & Giudice, L. C. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1716687 · Cited by 331
Bazot, M., Fiori, O., & Daraï, É. (2006) · Human Reproduction · doi:10.1093/humrep/dei448 · Cited by 283
Metadata
- Authors
- Kunz, G.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Kunz, G
- ORCID
- Kunz, G
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-09-01
- Volume
- 4
- Issue
- 5
- Pages
- 647-654
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2105768051
- Cited by
- 136
- References
- 45
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
- Keywords
- uterine peristalsis, follicular phase, menstrual cycle, estradiol, oxytocin, clomiphene citrate, antiestrogens, sperm transport, dominant follicle, endometrium, autocrine and paracrine regulation, refractoriness, estradiol valerate, human menopausal gonadotropin, pituitary down-regulation, preovulatory phase
- MeSH terms
- Adult, Clomiphene, Embryo Transfer, Endometrium, Estradiol, Estrogen Antagonists, Female, Follicular Phase, Humans, Middle Aged, Muscle Contraction, Muscle, Smooth, Ovary, Oxytocin, Ultrasonography, Uterus, Vagina, Triptorelin Pamoate
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