Uterine hyperperistalsis and dysperistalsis as dysfunctions of the mechanism of rapid sperm transport in patients with endometriosis and infertility
Abstract
Women suffering from infertility in association with mostly mild endometriosis were subjected to vaginal sonography of uterine peristalsis during the menstrual period, the early, mid- and late follicular phases, and the mid-luteal phase of the menstrual cycle. The data obtained were compared with those of healthy controls. Women with endometriosis displayed a marked uterine hyperperistalsis that differed significantly from the peristalsis of the controls during the early and mid-follicular and mid-luteal phases. During the late follicular phase of the cycle, uterine peristalsis in women with endometriosis became dysperistaltic, arrhythmic and convulsive in character, while in controls peristalsis continued to show long and regular cervico-fundal contractions. Hysterosalpingoscintigraphy during the early, mid- and late follicular phases revealed that hyperperistalsis in the early and mid-follicular phases of patients with endometriosis resulted in a dramatic increase in the transport of inert particles from the vaginal depot, through the uterus into the tubes and also into the peritoneal cavity. During the late follicular phase of the cycle, the dysperistalsis observed in women with endometriosis resulted in a dramatic reduction of uterine transport capacity in comparison with the healthy controls. We consider uterine hyperperistalsis to be the mechanical cause of endometriosis rather than retrograde menstruation. Dysperistalsis in the late follicular phase of patients with endometriosis may compromise rapid sperm transport. Uterine hyperperistalsis and dysperistalsis are considered to be responsible for both reduced fertility and the development of endometriosis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Uterine hyperperistalsis/dysperistalsis may result from archimetral hyperestrogenism.
“Third, uterine hyperperistalsis/dysperistalsis may be a result of archimetral hyperestrogenism [38,47].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [38]
Uterine peristalsis is critical for sperm transport, and women with endometriosis exhibit hyperperistalsis and dysperistalsis.
“In a nutshell, they showed that uterine peristalsis is critical for sperm transport, and women with endometriosis exhibit hyperperistalsis and dysperistalsis [38,39,40,41].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [38]
Uterine dysfunction in women with endometriosis and adenomyosis is a result of archimetral hyperestrogenism.
“It was suggested that this uterine dysfunction in women with endometriosis and adenomyosis is a result of archimetral hyperestrogenism [3, 4, 29, 33].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [29]
Uterine function of rapid and directed sperm transport into the dominant tube is dysfunctional in women with endometriosis and is characterized by hyper- and dysperistalsis.
“The uterine function of rapid and directed sperm transport into the ‘dominant tube’ is dysfunctional in women with endometriosis and is characterized by hyper- and dysperistalsis [27–32].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [29]
Intensity of uterine peristaltic activity in women with endometriosis resembles that of women during controlled ovarian hyperstimulation although peripheral estradiol levels are within normal range.
“The intensity of uterine peristaltic activity in women with endometriosis resembles that of women during controlled ovarian hyperstimulation although the peripheral estradiol levels are within the normal range [4, 29, 44].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [29]
Cites
The publisher hasn’t deposited this paper’s reference list.
Cited by
Sorted by citations
Role of oxidative stress in female reproduction
Agarwal, A., Gupta, S., & Sharma, R. K. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-28 · Cited by 1,729 · see citing works
“Significant differences are seen in the uterine hyperperistalsis and dysperistalsis in patients with endometriosis compared with the control groups, and this may be responsible for disturbed sperm transport and reduced fertility [137].”
Benagiano, G., & Brosens, I. A. (2006) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2006.01.007 · Cited by 536 · see citing works
Fanchin, R. R. F., Righini, C., Olivennes, F. J., Taylor, S., de Ziegler, D., & Frydman, R. (1998) · Human Reproduction · doi:10.1093/humrep/13.7.1968 · Cited by 528 · see citing works
Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications
Stratton, P., & Berkley, K. J. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmq050 · Cited by 442 · see citing works
“Mean contraction pressure and frequency is higher and more frequent, and results in more retrograde endometrial debris in women with endometriosis than controls (Salamanca and Beltran, 1995; Bulletti et al., 1996; Leyendecker et al., 1996).”
BackgroundEndometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options
Tanbo, T., & Fedorcsak, P. (2017) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1111/aogs.13082 · Cited by 432 · see citing works
“In endometriosis, uterotubal dysperistalsis may contribute to infertility because of disturbed transport of gametes and embryos (42).”
BackgroundBIOFLUIDMECHANICS OF REPRODUCTION
Fauci, L., & Dillon, R. H. (2005) · Annual Review of Fluid Mechanics · doi:10.1146/annurev.fluid.37.061903.175725 · Cited by 428 · see citing works
“Leyendecker et al. (1996) measured uterine peristaltic activity in women with fertility problems due to endometriosis.”
BackgroundThe pathophysiology of endometriosis and adenomyosis, tissue injury and repair
Leyendecker, G., Wildt, L., & Mall, G. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1191-0 · Cited by 418 · see citing works
“production of estrogen would constitute a mechanical trauma resulting in an increased desquamation of fragments of basal endometrium and [21], in combination with an increased retrograde uterine transport capacity [29], in enhanced transtubal dissemination of these fragments.”
BackgroundInfluentialSelf-citationBrosens, I. A., & Brosens, J. J. (2000) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00265-7 · Cited by 392 · see citing works
Kunz, G., Beil, D., Huppert, P., Noe, M., Kissler, S., & Leyendecker, G. (2005) · Human Reproduction · doi:10.1093/humrep/dei021 · Cited by 377 · see citing works
“Evidence from magnetic resonance imaging”
BackgroundResultInfluentialSelf-citationEuropean society of urogenital radiology (ESUR) guidelines: MR imaging of pelvic endometriosis
Bazot, M., Bharwani, N., Huchon, C., Kinkel, K., Cunha, T. M., Guerra, A., Manganaro, L., Buñesch, L., Kido, A., Togashi, K., et al. (2016) · European Radiology · doi:10.1007/s00330-016-4673-z · Cited by 345 · see citing works
“This abnormal uterine peristalsis in endometriosis patients could interfere with fertility [79].”
Pathogenesis of adenomyosis, an update on molecular mechanisms
Vannuccini, S., Tosti, C., Carmona, F., Huang, S. J., Chapron, C., Guo, S.-W., & Petraglia, F. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.06.016 · Cited by 326 · see citing works
“…is described as a cause of infertility and negative assisted reproductive technologies outcomes (Vercellini et al., 2014), possibly due to the alteration of the normal myometrial architecture that disturbs the uterine environment, uterine peristalsis and sperm transport (Leyendecker et al., 1996).”
Endometriosis-associated infertility: From pathophysiology to tailored treatment
Bonavina, G., & Taylor, H. S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1020827 · Cited by 359 · see citing works
“Gamete transport is also affected by the inflammatory microenvironment, anatomical distortions and uterotubal dysperistalsis associated with endometriosis (15).”
BackgroundDistribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis
Ota, H., Igarashi, S., Sasaki, M., & Tanaka, T. (2001) · Human Reproduction · doi:10.1093/humrep/16.3.561 · Cited by 301 · see citing works
“Polarity in the basal and apical sides was not Myometrial movement in patients with endometriosis was observed using ultrasonography (Leyendecker et al., 1996)particularly pronounced.”
BackgroundEndometriosis results from the dislocation of basal endometrium
Leyendecker, G. (2002) · Human Reproduction · doi:10.1093/humrep/17.10.2725 · Cited by 300 · see citing works
Self-citationVinatier, D., Orazi, G., Cosson, M., & Dufour, P. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00405-x · Cited by 299 · see citing works
Adenomyosis: Mechanisms and Pathogenesis
Zhai, J., Vannuccini, S., Petraglia, F., & Giudice, L. C. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1716687 · Cited by 331 · see citing works
Bazot, M., Fiori, O., & Daraï, É. (2006) · Human Reproduction · doi:10.1093/humrep/dei448 · Cited by 282 · see citing works
Salliss, M. E., Farland, L. V., Mahnert, N. D., & Herbst‐Kralovetz, M. M. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab035 · Cited by 287 · see citing works
Leyendecker, G., Bilgicyildirim, A., Inacker, M., Stalf, T., Huppert, P., Mall, G., Böttcher, B., & Wildt, L. (2015) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-014-3437-8 · Cited by 261 · see citing works
“vulsive pattern of the peristaltic activity and in a breakdown of directed sperm transport [30].”
BackgroundSelf-citationRole of oxidative stress in endometriosis
Gupta, S., Agarwal, A., Krajcir, N., & Alvarez, J. G. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)62026-3 · Cited by 240 · see citing works
“found in patients with endometriosis compared with controls, which may be responsible for defective sperm transport and reduced fertility (Leyendecker et al., 1996).”
BackgroundNoe, M. (1999) · Human Reproduction · doi:10.1093/humrep/14.1.190 · Cited by 216 · see citing works
“They consist in the cyclic preparation of the endometrium for implantation and in the cyclically changing uterine peristalsis with the main function of uterine sperm transport (De Vrieset al., 1990; Kunzet al., 1996; Leyendecker et al., 1996).”
BackgroundNg, K. Y. B., Mingels, R., Morgan, H., Macklon, N., & Cheong, Y. C. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx028 · Cited by 208 · see citing works
Embryo transfer--can we learn anything new from the observation of junctional zone contractions?
Lesny, P., Killick, S. R., Tetlow, R. L., Robinson, J., & Maguiness, S. D. (1998) · Human Reproduction · doi:10.1093/humrep/13.6.1540 · Cited by 206 · see citing works
“Embryo transfer—can we learn anything new from the observation of junctional zone contractions?”
BackgroundUterine contractility during the menstrual cycle
Bulletti, C., de Ziegler, D., POLLI, V., Diotallevi, L., Ferro, E. D., & Flamigni, C. (2000) · Human Reproduction · doi:10.1093/humrep/15.suppl_1.81 · Cited by 205 · see citing works
“Using "Tc-labelled macro-albumin aggregates, it has been shown (Leyendecker et al., 1996) that some individuals, particularly women suffering from endometriosis, failed to have proper retrograde displacement of uterine content in the pre-ovulatory phase.”
BackgroundKunz, G., & LEYENDECKER, G. (2002) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(12)60108-4 · Cited by 201 · see citing works
“The present authors consider that this benefit might be the preservation of body iron (Leyendecker et al., 1996).”
BackgroundSelf-citationEndometriosis: A dysfunction and disease of the archimetra
Leyendecker, G. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.752 · Cited by 199 · see citing works
“Some women develop severe endometriosis following childbirth and some women present with mild-to-moderate endometriosis, with uterine hyper- and dysperistalsis being the reason for their primary sterility (Leyendecker et al., 1996).”
InfluentialSelf-citationThe pathophysiology of uterine adenomyosis: an update
Benagiano, G., Habiba, M. A., & Brosens, I. A. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.06.044 · Cited by 187 · see citing works
Kunz, G., Beil, D., Huppert, P., & Leyendecker, G. (2000) · Human Reproduction · doi:10.1093/humrep/15.1.76 · Cited by 177 · see citing works
“…1999), function and activity during the and the eutopic endometrium, respectively, in women with endometriosis.menstrual cycle (Kunz et al., 1996; Leyendecker et al., 1996) as well as cellular (Wetzstein, 1965; Schwalm and Dubrauszky, Moreover, the data provide evidence that endometriosis and…”
BackgroundInfluentialSelf-citationPhysiology of Upward Transport in the Human Female Genital Tract
ZERVOMANOLAKIS, I., OTT, H. W., HADZIOMEROVIC, D., MATTLE, V., SEEBER, B. E., VIRGOLINI, I., HEUTE, D., KISSLER, S., LEYENDECKER, G., & WILDT, L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1389.032 · Cited by 165 · see citing works
Self-citationUterine peristaltic activity and the development of endometriosis
LEYENDECKER, G., KUNZ, G., HERBERTZ, M., BEIL, D., HUPPERT, P., MALL, G., KISSLER, S., NOE, M., & WILDT, L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1335.036 · Cited by 162 · see citing works
Self-citationThe Pathogenesis of Adenomyosis vis-à-vis Endometriosis
Guo, S.-W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020485 · Cited by 165 · see citing works
“Third, uterine hyperperistalsis/dysperistalsis may be a result of archimetral hyperestrogenism [38,47].”
BackgroundUterine contractility and embryo implantation
Bulletti, C., & de Ziegler, D. (2005) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/01.gco.0000169104.85128.0e · Cited by 160 · see citing works
Cellular and molecular basis for endometriosis-associated infertility
Stilley, J. A. W., Birt, J. A., & Sharpe-Timms, K. L. (2012) · Cell and Tissue Research · doi:10.1007/s00441-011-1309-0 · Cited by 151 · see citing works
“Uterine/oviductal sperm transport is impaired in endometriosis (Kissler et al. 2005, 2006, 2007; Leyendecker et al. 1996).”
BackgroundWildt, L. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.655 · Cited by 149 · see citing works
Self-citationMyometrial zonal differentiation and uterine junctional zone hyperplasia in the non-pregnant uterus
Brosens, J. J. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.496 · Cited by 148 · see citing works
“Junctional zone dysfunction has been implicated in the pathogenesis of pelvic endometriosis and subfertility (Salamanca and Beltrán, 1995; Leyendecker et al., 1996; Ijland et al., 1997).”
BackgroundUterotubal transport disorder in adenomyosis and endometriosis—a cause for infertility
Kissler, S., Hamscho, N., Zangos, S., Wiegratz, I., Schlichter, S., Menzel, C., Doebert, N., Gruenwald, F., Vogl, T., Gaetje, R., et al. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00970.x · Cited by 146 · see citing works
Self-citationA new concept of endometriosis and adenomyosis, tissue injury and repair (TIAR)
Leyendecker, G., & Wildt, L. (2011) · hmbci · doi:10.1515/hmbci.2011.002 · Cited by 147 · see citing works
Self-citationKunz, G. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.647 · Cited by 136 · see citing works
Self-citationLazzeri, L., Di Giovanni, A., Exacoustos, C., Tosti, C., Pinzauti, S., Malzoni, M., Petraglia, F., & Zupi, E. (2014) · Reproductive Sciences · doi:10.1177/1933719114522520 · Cited by 137 · see citing works
Gutsche, S. (2003) · Molecular Human Reproduction · doi:10.1093/molehr/gag095 · Cited by 134 · see citing works
“On the other hand, experiments by Leyendecker et al. (1996) and Kunz et al. (1997) have demonstrated that technetium-labelled albumin macrospheres, placed at the external os of the cervix, reached the tubes within 1 min due to subendometrial and myometrial peristaltic waves.”
BackgroundGuo, S.-W., Mao, X., Ma, Q., & Liu, X. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.038 · Cited by 131 · see citing works
Kuijsters, N. P. M., Methorst, W., Kortenhorst, M. S. Q., Rabotti, C., Mischi, M., & Schoot, B. C. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.03.019 · Cited by 131 · see citing works
“A suspension labelled with radioactive tracers is injected into the uterine cavity and migration of the suspension is traced by a gamma camera (Bulletti and de Ziegler, 2006; Kunz et al., 1996; Leyendecker et al., 1996).”
BackgroundMethodEndometrial wave-like activity in the non-pregnant uterus
van Gestel, I. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg011 · Cited by 127 · see citing works
“This method seems comparable with those reported previously (de Vries et al., 1990; Lyons et al., 1991; Leyendecker et al., 1996), in which the analysis was conducted at ®ve times normal speed.”
BackgroundMethodInfluentialCrawford, G., Ray, A., Gudi, A., Shah, A., & Homburg, R. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmu052 · Cited by 124 · see citing works
“The female immune response is further stimulated by seminal plasma via the drainage of seminal antigen through the lymphatic system (Leyendecker et al., 1996; Johansson et al., 2004).”
BackgroundZhu, L., S., H., Xiao, L., & Li, Y. (2014) · Human Reproduction · doi:10.1093/humrep/deu058 · Cited by 122 · see citing works
“Previous studies (Kunz et al., 1996; Leyendecker et al., 1996; IJland et al., 1997a; Fanchin et al., 1998; Bulletti et al., 2000; Nakai et al., 2008; Zhu et al., 2012) have reachedaconsensus on the percentage distribution of uterine peristalsis wave types in menstrual cycle, i.”
BackgroundFemale Infertility and Free Radicals: Potential Role in Adhesions and Endometriosis
Alpay, Z., Saed, G. M., & Diamond, M. P. (2006) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2006.05.002 · Cited by 119 · see citing works
Ota, H., Igarashi, S., Hatazawa, J., & Tanaka, T. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00478-0 · Cited by 115 · see citing works
Is endometriosis an endometrial disease?
Vinatier, D., Cosson, M., & Dufour, P. (2000) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(99)00263-8 · Cited by 115 · see citing works
Kunz, G., Beil, D., Deiniger, Н., Einspanier, A., Mall, G., & LEYENDECKER, G. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5913-9_49 · Cited by 112 · see citing works
Self-citationUterine contractility and embryo implantation
Bulletti, C., & de Ziegler, D. (2006) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/01.gco.0000233947.97543.c4 · Cited by 111 · see citing works
Adenomyosis as a disorder of the early and late human reproductive period
Kunz, G., Herbertz, M., Beil, D., Huppert, P., & Leyendecker, G. (2007) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60535-4 · Cited by 108 · see citing works
Self-citationUterine junctional zone contractions during assisted reproduction cycles. VIDEO
Lesny, P. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.4.440 · Cited by 107 · see citing works
Biomechanics of the human uterus
Myers, K. M., & Elad, D. (2017) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1388 · Cited by 101 · see citing works
Parker, J. D., Leondires, M., Sinaii, N., Premkumar, A., Nieman, L. K., & Stratton, P. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.01.030 · Cited by 98 · see citing works
Contractility of the Nonpregnant Uterus
de Ziegler, D., Bulletti, C., Fanchin, R. R. F., Epiney, M., & Brioschi, P. A. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03801.x · Cited by 98 · see citing works
Leyendecker, G., Kunz, G., Kissler, S., & Wildt, L. (2006) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2006.01.008 · Cited by 94 · see citing works
Self-citationRombauts, L. J. F., Motteram, C., Berkowitz, E., & Fernando, S. (2014) · Human Reproduction · doi:10.1093/humrep/deu240 · Cited by 92 · see citing works
“It has, however, been shown that, here too, the presence of endometriosis can increase the irregularity of uterine wave-like contractions during the late follicular phase of the menstrual cycle, resulting in impaired movement of fluid through the uterus (Leyendecker et al., 1996; Kunz et al., 2000).”
BackgroundUtero‐Tubal Sperm Transport and Its Impairment in Endometriosis and Adenomyosis
KISSLER, S., ZANGOS, S., WIEGRATZ, I., KOHL, J., RODY, A., GAETJE, R., DOEBERT, N., WILDT, L., KUNZ, G., LEYENDECKER, G., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1389.036 · Cited by 89 · see citing works
Self-citationSillem, M. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.730 · Cited by 86 · see citing works
“In particular, the first mechanism would fit in well with the observations regarding retrograde seeding by Bartosik et al. (1986) and uterine dysperistalsis by Leyendecker et al. (1996), as discussed in the Introduction.”
Myomas and Adenomyosis: Impact on Reproductive Outcome
Vlahos, N., Theodoridis, T. D., & Partsinevelos, G. A. (2017) · BioMed Research International · doi:10.1155/2017/5926470 · Cited by 85 · see citing works
Duration of dysmenorrhoea and extent of adenomyosis visualised by magnetic resonance imaging
Kissler, S., Zangos, S., Kohl, J., Wiegratz, I., Rody, A., Gätje, R., Vogl, T. J., Kunz, G., LEYENDECKER, G., & Kaufmann, M. (2007) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2007.01.015 · Cited by 85 · see citing works
“At the same time endometriosis results from the detachment of endometrial cells with a higher potential for proliferation and infiltrative growth and from their enhanced transtubal transport by uterine hyperperistalsis into the peritoneal cavity, where they implant on peritoneal surfaces [13,14].”
BackgroundSelf-citationMechsner, S., Bartley, J., Loddenkemper, C., Salomon, D. S., Starzinski-Powitz, A., & Ebert, A. D. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.11.038 · Cited by 79 · see citing works
Ultrasound tracking of the movement of embryo-associated air bubbles on standing after transfer
Woolcott, R. J., & Stanger, J. D. (1998) · Human Reproduction · doi:10.1093/humrep/13.8.2107 · Cited by 78 · see citing works
“It was technically easy to perform transvaginal pelvic ultrasound in an upright position and the procedure was readily accepted by patients.”
MethodTumor necrosis factor alpha secretion by peritoneal macrophages in patients with endometriosis
Richter, O. N., Dorn, C., R�sing, B., Flaskamp, C., & Ulrich, U. A. (2004) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-003-0591-9 · Cited by 79 · see citing works
“While widely accepted, common hypotheses such as the transtubal transplantation by retrograde menstruation [12], the somatic and metaplastic theory [24], the lymphogenic or hematogenic transplantation, the autoimmune theory [3, 20, 47], as well as the transtubal transplantation of M llerian tract epithelia by the uter…”
BackgroundCine MR imaging of uterine peristalsis in patients with endometriosis
Kido, A., Togashi, K., Nishino, M., Miyake, K. K., Koyama, T., Fujimoto, R., Iwasaku, K., Fujii, S., & Hayakawa, K. (2006) · European Radiology · doi:10.1007/s00330-006-0494-9 · Cited by 75 · see citing works
Chen, J. C., Johnson, B., Erikson, D. W., et al. (2014) · Human Reproduction · doi:10.1093/humrep/deu047 · Cited by 78 · see citing works
Orisaka, M., Kurokawa, T., Shukunami, K., Orisaka, S., Fukuda, M., Shinagawa, A., Fukuda, S., Ihara, N., Yamada, H., Itoh, H., et al. (2007) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2006.07.040 · Cited by 75 · see citing works
“Nevertheless, previous reports have suggested that the detection of disturbances of peristaltic pattern may identify new causal aspect(s) of infertility [1,11].”
BackgroundUterine contractions evaluated on cine MR imaging in patients with uterine leiomyomas
Nishino, M., Togashi, K., Nakai, A., Hayakawa, K., Kanao, S., Iwasaku, K., & Fujii, S. (2004) · European Journal of Radiology · doi:10.1016/j.ejrad.2004.01.009 · Cited by 74 · see citing works
“The dysfunction of peristaltic movement has been postulated as the cause of a variety of gynecological and obstetrical problems including endometriosis, infertility, and pregnancy wastage [10,12,15].”
BackgroundMethodInfluentialWalker, C. K., Workowski, K., Washington, A. E., Soper, D. E., & Sweet, R. L. (1999) · Clinical Infectious Diseases · doi:10.1086/514720 · Cited by 72 · see citing works
“Investigators using vaginal sonography have described a series of abnormal uterine peristalsis forms that may be associated with the development of endometriosis [51], and retrograde menstruation has been considered a likely candidate in the pathogenesis of this disease [52].”
Development of placental abnormalities in location and anatomy
Jansen, C. H. J. R., Kastelein, A. W., Kleinrouweler, C. E., van Leeuwen, E., de Jong, K. H., Pajkrt, E., & Noorden, C. J. F. V. (2020) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13834 · Cited by 85 · see citing works
Faserl, K., Golderer, G., Kremser, L., Lindner, H. H., Sarg, B., Wildt, L., & Seeber, B. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1532 · Cited by 71 · see citing works
Self-citationIs there an association between septate uterus and endometriosis?
Nawroth, F., Rahimi, G., Nawroth, C., Foth, D., Ludwig, M., & Schmidt, T. (2006) · Human Reproduction · doi:10.1093/humrep/dei344 · Cited by 70 · see citing works
Redefining endometriosis: is deep endometriosis a progressive disease?
Brosens, I. A., & Brosens, J. J. (2000) · Human Reproduction · doi:10.1093/humrep/15.1.1 · Cited by 69 · see citing works
The Patterns of Uterine Contractility in Normal Menstruating Women: From Physiology to Pathology
BULLETTI, C., DE ZIEGLER, D., SETTI, P. L., CICINELLI, E., POLLI, V., & FLAMIGNI, C. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1335.007 · Cited by 69 · see citing works
New concepts on the etiology of endometriosis
Cousins, F. L., McKinnon, B. D., Mortlock, S., Fitzgerald, H. C., Zhang, C., Montgomery, G. W., & Gargett, C. E. (2023) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15549 · Cited by 82 · see citing works
Magnetically Bioprinted Human Myometrial 3D Cell Rings as A Model for Uterine Contractility
Souza, G. R., Tseng, H., Gage, J. A., Mani, A., Desai, P. K., Leonard, F., Liao, A., Longo, M., Refuerzo, J., & Godin, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040683 · Cited by 68 · see citing works
Is the endometrium or oocyte/embryo affected in endometriosis?
Garcia-Velasco, J. A., & Arici, A. (1999) · Human Reproduction · doi:10.1093/humrep/14.suppl_2.77 · Cited by 68 · see citing works
Moon, H. S., Park, S. H., Lee, J. O., Kim, K. S., & Joo, B. S. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.02.140 · Cited by 65 · see citing works
REVIEW: The junctional zone of the uterus and its contractions
Lesny, P., & Killick, S. R. (2004) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2004.00350.x · Cited by 62 · see citing works
Anatomy and physiology of the female pelvis: MR imaging revisited
Togashi, K., Nakai, A., & Sugimura, K. (2001) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1120 · Cited by 62 · see citing works
“Dysfunction of peristalsis is postulated as a cause of endometriosis, infertility, and a variety of symptoms (13,14).”
BackgroundTakemura, Y., Osuga, Y., Fujimoto, A., Oi, N., Tsutsumi, R., Koizumi, M., Yano, T., & Taketani, Y. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2012.706669 · Cited by 61 · see citing works
“However, in women with endometriosis, muscular movement of the uterus is abnormally increased in implantation period [18], which may disturb the implantation of embryos in initially transplanted areas.”
BackgroundEndometriosis: harmful survival of an ectopic tissue
Garai, J. (2006) · Frontiers in bioscience · doi:10.2741/1821 · Cited by 61 · see citing works
Serum oxytocin concentration during embryo transfer procedure
Dorn, C., REINSBERG, J., Schlebusch, H., et al. (1999) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(99)00077-9 · Cited by 61 · see citing works
Tocci, A., Greco, E., & Ubaldi, F. M. (2008) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60207-6 · Cited by 60 · see citing works
“unit causing a perturbation of uterine peristalsis which in turn interferes with reproductive outcome (Leyendecker et al., 1996; Fusi et al., 2006).”
BackgroundThe known, the unknown and the future of the pathophysiology of endometriosis
Ochoa Bernal, M. A., & Fazleabas, A. T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115815 · Cited by 59 · see citing works
“…peristaltic activity, or hyperperistalsis, a mechanical trauma resulting in increased desquamation of tissue fragments of the basal endometrium [33], which could induce micro-traumatization at the endometrium–myometrium interface, activating TIAR and causing an increase in local production of…”
BackgroundManagement of Adenomyosis in Subfertile Women and Pregnancy Outcome
Jama, F. A. (2011) · Oman Medical Journal · doi:10.5001/omj.2011.43 · Cited by 59 · see citing works
Kissler, S., Hamscho, N., Zangos, S., Gätje, R., Müller, A., Rody, A., Döbert, N., Menzel, C., Grünwald, F., Siebzehnrübl, E., et al. (2005) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2005.00676.x · Cited by 57 · see citing works
“Our data confirm the results of Leyendecker et al.(3) who reported a 2.”
BackgroundResultInfluentialMasuda, H., Schwab, K. E., Filby, C. E., Tan, C., Tsaltas, J., Weston, G. C., & Gargett, C. E. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.04.008 · Cited by 58 · see citing works
Structure, Function, and Evaluation of the Female Reproductive Tract
Lessey, B. A., & Young, S. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00009-3 · Cited by 58 · see citing works
Malvası, A., Cavallotti, C. A. P., Nicolardi, G., Pellegrino, M., Dell’Edera, D., Vergara, D., Gréco, M., Kumakiri, J., & Tinelli, A. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2012.708803 · Cited by 53 · see citing works
“These results agree with others that have suggested that detecting disturbances in the uterine peristaltic pattern may identify new causal aspects of infertility [35,36].”
Resultvon Wolff, M., Rösner, S., Thöne, C., et al. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.11.036 · Cited by 52 · see citing works
Huang, M., Li, X., Guo, P., Yu, Z., Xu, Y., & Wei, Z. (2017) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0220-7 · Cited by 52 · see citing works
Ultrasound and the receptivity of the endometrium
Killick, S. R. (2007) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60693-1 · Cited by 52 · see citing works
Endometriosis: absence of recurrence in patients after endometrial ablation
Bulletti, C., DeZiegler, D., Stefanetti, M., Cincinelli, E., Pelosi, E., & Flamigni, C. (2001) · Human Reproduction · doi:10.1093/humrep/16.12.2676 · Cited by 50 · see citing works
Oppelt, P., Renner, S. P., Strick, R., Valletta, D., Mehlhorn, G., Fasching, P. A., Beckmann, M. W., & Strissel, P. L. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.12.061 · Cited by 48 · see citing works
Harada, M., Osuga, Y., Hirota, Y., Koga, K., Morimoto, C., Hirata, T., Yoshino, O., Tsutsumi, O., Yano, T., & Taketani, Y. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1089 · Cited by 48 · see citing works
Redefining endometriosis: Endometriosis is an entity with extreme pleiomorphism
Leyendecker, G. (2000) · Human Reproduction · doi:10.1093/humrep/15.1.4 · Cited by 49 · see citing works
Self-citationDheenadayalu, K., Mak, I., Gordts, S., Campo, R., HIGHAM, J. M., Puttemans, P., WHITE, J. O., Christian, M., Fusi, L., & Brosens, J. J. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03324-1 · Cited by 49 · see citing works
Woolcott, R. J., Fisher, S., Thomas, J., & Kable, W. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00382-9 · Cited by 47 · see citing works
Endometriosis and Free Radicals
Ota, H., Igarashi, S., Hatazawa, J., & Tanaka, T. (1999) · Gynecologic and Obstetric Investigation · doi:10.1159/000052866 · Cited by 48 · see citing works
- Authors
- Leyendecker, G., Kunz, G., Wildt, L., Beil, D., & Deininger, H.
- Affiliations
- Klinikum Darmstadt (DE)
- Goethe University Frankfurt (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-07-01
- Volume
- 11
- Issue
- 7
- Pages
- 1542-1551
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W1992297132
- Cited by
- 307
- References
- 0
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 12 · 2023: 12 · 2022: 8 · 2021: 6 · 2020: 32 · 2019: 10 · 2018: 6 · 2017: 14 · 2016: 7 · 2015: 12 · 2014: 10 · 2013: 6 · 2012: 9
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- endometriosis, infertility, uterine peristalsis, sperm transport, menstrual cycle phases, follicular phase, luteal phase, retrograde menstruation, uterine motility
- MeSH terms
- Adult, Endometriosis, Fallopian Tubes, Female, Follicular Phase, Humans, Infertility, Female, Luteal Phase, Male, Middle Aged, Radionuclide Imaging, Sperm Transport, Ultrasonography, Uterine Contraction, Uterus, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
