The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Apoptosis in the ovary: molecular mechanisms
Abstract
Cell death was first described in rabbit ovaries (Graaffian follicles), the phenomenon being called 'chromatolysis' rather than apoptosis. In humans, the ovarian endowment of primordial follicles is established during fetal life. Apoptotic cell death depletes this endowment by at least two-thirds before birth, executed with the help of several players and pathways conserved from worms to humans. To date, apoptosis has been reported to be involved in oogenesis, folliculogenesis, oocyte loss/selection and atresia. Several pro-survival and pro-apoptotic molecules are involved in ovarian apoptosis with the delicate balance between them being the determinant for the final destiny of the follicular cells. This review critically analyses the current knowledge about the biological roles of these molecules and their relevance to the dynamics of follicle development. It also presents the existing literature and assesses the gaps in our knowledge.
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Cites
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Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions
Li, L., Dong, J., Yan, L., Yong, J., Liu, X., Hu, Y., Fan, X., Wu, X., Guo, H., Wang, X., et al. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.03.007 · Cited by 561
A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations
Fan, W., Waymire, K. G., Narula, N., Li, P., Rocher, C., Coskun, P. E., Vannan, M. A., Narula, J., MacGregor, G. R., & Wallace, D. C. (2008) · Science · doi:10.1126/science.1147786 · Cited by 466
Impact of folate and homocysteine metabolism on human reproductive health
Forges, T., Monnier-Barbarino, P., Alberto, J. M., Guéant-Rodriguez, R. M., Daval, J. L., & Guéant, J. L. (2007) · Human Reproduction Update · doi:10.1093/humupd/dml063 · Cited by 300
Hanukoglu, I. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600570040 · Cited by 293
Chang, H.-M., Qiao, J., & Leung, P. C. K. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw039 · Cited by 265
Metadata
- Authors
- Hussein, M. R.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-03-01
- Volume
- 11
- Issue
- 2
- Pages
- 162-178
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2121974974
- Cited by
- 502
- References
- 98
- FWCI
- 16.17
- Type
- journal article
- Language
- en
- Open access
- closed
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