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Cited by 262Ovarian function and disordersAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis

Toulis, K.A., Goulis, D.G., Farmakiotis, D., Georgopoulos, N.A., Katsikis, I., Tarlatzis, B.C., Papadimas, I., Panidis, D.·2009·Human Reproduction Update
DOI 10.1093/humupd/dmp006
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Abstract

BACKGROUND: Conflicting results regarding adiponectin levels in women with polycystic ovary syndrome (PCOS) have been reported. To evaluate adiponectin levels in PCOS, a systematic review of all studies comparing adiponectin levels in women with PCOS with healthy controls and a meta-analysis of those involving women with similar body mass index (BMI) were performed. The influence of possible effect modifiers, such as insulin resistance (IR) and testosterone, was investigated. The influence of obesity was investigated through a 'nested' meta-analysis after within-study BMI stratification and appropriate pooling. METHODS: Literature search was conducted through MEDLINE, EMBASE, Cochrane CENTRAL (through June 2008), references from relevant studies and personal contact with the authors. Thirty-one studies, reporting data on 3469 subjects, were reviewed and 16 included in the main meta-analysis. RESULTS: Women with PCOS demonstrated significantly lower adiponectin values [weighted mean difference (95% confidence interval) -1.71 (-2.82 to -0.6), P < 10(-4)], yet with significant between-study heterogeneity. Lower adiponectin levels are associated with the IR observed in women with PCOS, compared with controls. IR, but not total testosterone, was found significant among biological parameters explored in the meta-regression model. Hypoadiponectinaemia was present in both lean and obese women with PCOS when compared with non-PCOS counterparts. Data on high molecular weight (HMW) adiponectin are limited (three studies). CONCLUSIONS: After controlling for BMI-related effects, adiponectin levels seem to be lower in women with PCOS compared with non-PCOS controls. Low levels of adiponectin in PCOS are probably related to IR but not to testosterone. Total adiponectin should not be used as a biomarker of PCOS severity. Further investigation is needed for HMW adiponectin levels in PCOS.

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Metadata

Authors
Toulis, K. A., Goulis, D. G., Farmakiotis, D., Georgopoulos, N. A., Katsikis, I., Tarlatzis, B. C., Papadimas, I., & Panidis, D.
Affiliations
  • Aristotle University of Thessaloniki (GR)
  • University of Patras (GR)
ORCID
Venue
Human Reproduction Update
Publisher
Oxford University Press (OUP)
Published
2009
Volume
15
Issue
3
Pages
297-307
ISSN
  • 1355-4786 (ISSN-L)
  • 1460-2369
DOI
10.1093/humupd/dmp006
OpenAlex
W2131241159
Cited by
262
References
72
Citations by year
2026: 10 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 14 · 2021: 20 · 2020: 19 · 2019: 13 · 2018: 12 · 2017: 17 · 2016: 10 · 2015: 21 · 2014: 17 · 2013: 23 · 2012: 25
FWCI
2.73
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction Update (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Warwick
  • University of Adelaide
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
polycystic ovary syndrome, adiponectin, insulin resistance, testosterone, obesity, body mass index, high molecular weight adiponectin
MeSH terms
Female, Humans, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Regression Analysis, Testosterone, Adiponectin

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