The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis
Abstract
BACKGROUND: Conflicting results regarding adiponectin levels in women with polycystic ovary syndrome (PCOS) have been reported. To evaluate adiponectin levels in PCOS, a systematic review of all studies comparing adiponectin levels in women with PCOS with healthy controls and a meta-analysis of those involving women with similar body mass index (BMI) were performed. The influence of possible effect modifiers, such as insulin resistance (IR) and testosterone, was investigated. The influence of obesity was investigated through a 'nested' meta-analysis after within-study BMI stratification and appropriate pooling. METHODS: Literature search was conducted through MEDLINE, EMBASE, Cochrane CENTRAL (through June 2008), references from relevant studies and personal contact with the authors. Thirty-one studies, reporting data on 3469 subjects, were reviewed and 16 included in the main meta-analysis. RESULTS: Women with PCOS demonstrated significantly lower adiponectin values [weighted mean difference (95% confidence interval) -1.71 (-2.82 to -0.6), P < 10(-4)], yet with significant between-study heterogeneity. Lower adiponectin levels are associated with the IR observed in women with PCOS, compared with controls. IR, but not total testosterone, was found significant among biological parameters explored in the meta-regression model. Hypoadiponectinaemia was present in both lean and obese women with PCOS when compared with non-PCOS counterparts. Data on high molecular weight (HMW) adiponectin are limited (three studies). CONCLUSIONS: After controlling for BMI-related effects, adiponectin levels seem to be lower in women with PCOS compared with non-PCOS controls. Low levels of adiponectin in PCOS are probably related to IR but not to testosterone. Total adiponectin should not be used as a biomarker of PCOS severity. Further investigation is needed for HMW adiponectin levels in PCOS.
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“after controlling for BMI-related effects, adiponectin levels appear to be lower in women with PCOS than in controls without PCOS [44].”
From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [44]
Citations
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“Women with PCOS appear to have lower levels of adiponectin than non-PCO controls, and obese anovulatory women with PCOS have lower levels still, although this is not a consistent finding in the literature (Carmina et al. 2005, 2009, Toulis et al. 2009).”
ResultIbáñez, L., Oberfield, S. E., Witchel, S., Auchus, R. J., Chang, R. J., Codner, E., Dabadghao, P., Darendeliler, F., Elbarbary, N. S., Gambineri, A., et al. (2017) · Hormone Research in Paediatrics · doi:10.1159/000479371 · Cited by 463
Metadata
- Authors
- Toulis, K. A., Goulis, D. G., Farmakiotis, D., Georgopoulos, N. A., Katsikis, I., Tarlatzis, B. C., Papadimas, I., & Panidis, D.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- University of Patras (GR)
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2009
- Volume
- 15
- Issue
- 3
- Pages
- 297-307
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2131241159
- Cited by
- 262
- References
- 72
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 14 · 2021: 20 · 2020: 19 · 2019: 13 · 2018: 12 · 2017: 17 · 2016: 10 · 2015: 21 · 2014: 17 · 2013: 23 · 2012: 25
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Warwick
- University of Adelaide
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, adiponectin, insulin resistance, testosterone, obesity, body mass index, high molecular weight adiponectin
- MeSH terms
- Female, Humans, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Regression Analysis, Testosterone, Adiponectin
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