The DOI matches its Crossref record; 280 of the 280 references it cites were found in a registry or an index.
Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology
Abstract
BACKGROUND: Endometriosis is a benign gynaecological disease. Thus, it came as a complete surprise when it was reported recently that the majority of deep endometriosis lesions harbour somatic mutations and a sizeable portion of them contain known cancer-associated mutations (CAMs). Four more studies have since been published, all demonstrating the existence of CAMs in different subtypes of endometriosis. While the field is still evolving, the confirmation of CAMs has raised many questions that were previously overlooked. OBJECTIVE AND RATIONALE: A comprehensive overview of CAMs in endometriosis has been produced. In addition, with the recently emerged understanding of the natural history of endometriotic lesions as well as CAMs in normal and apparently healthy tissues, this review attempts to address the following questions: Why has there been such a wild discrepancy in reported mutation frequencies? Why does ectopic endometrium have a higher mutation rate than that of eutopic endometrium? Would the presence of CAMs in endometriotic lesions increase the risk of cancer to the bearers? Why do endometriotic epithelial cells have much higher mutation frequencies than their stromal counterpart? What clinical implications, if any, do the CAMs have for the bearers? Do these CAMs tell us anything about the pathogenesis and/or pathophysiology of endometriosis? SEARCH METHODS: The PubMed database was searched, from its inception to September 2019, for all papers in English using the term ‘endometriosis and CAM’, ‘endometriosis and cancer-driver mutation’, ‘somatic mutations’, ‘fibrosis’, ‘fibrosis and epigenetic’, ‘CAMs and tumorigenesis’, ‘somatic mutation and normal tissues’, ‘oestrogen receptor and fibrosis’, ‘oxidative stress and fibrosis’, ‘ARID1A mutation’, and ‘Kirsten rat sarcoma mutation and therapeutics’. All retrieved papers were read and, when relevant, incorporated into the review results. OUTCOMES: Seven papers that identified CAMs in endometriosis using various sequencing methods were retrieved, and their results were somewhat different. Yet, it is apparent that those using microdissection techniques and more accurate sequencing methods found more CAMs, echoing recent discoveries that apparently healthy tissues also harbour CAMs as a result of the replicative aging process. Hence endometriotic lesions, irrespective of subtype, if left intact, would generate CAMs as part of replicative aging, oxidative stress and perhaps other factors yet to be identified and, in some rare cases, develop cancer. The published data still are unable to paint a clear picture on pathogenesis of endometriosis. However, since endometriotic epithelial cells have a higher turnover than their stromal counterpart due to cyclic bleeding, and since the endometriotic stromal component can be formed by refresh influx of mesenchymal cells through epithelial–mesenchymal transition, endothelial–mesenchymal transition, mesothelial–mesenchymal transition and other processes as well as recruitment of bone-marrow-derived stem cells and outflow due to smooth muscle metaplasia, endometriotic epithelial cells have much higher mutation frequencies than their stromal counterpart. The epithelial and stromal cellular components develop in a dependent and co-evolving manner. Genes involved in CAMs are likely to be active players in lesional fibrogenesis, and hyperestrogenism and oxidative stress are likely drivers of both CAMs and fibrogenesis. Finally, endometriotic lesions harbouring CAMs would conceivably be more refractory to medical treatment, due, in no small part, to their high fibrotic content and reduced vascularity and cellularity. WIDER IMPLICATIONS: The accumulating data on CAMs in endometriosis have shed new light on the pathogenesis and pathophysiology of endometriosis. They also suggest new challenges in management. The distinct yet co-evolving developmental trajectories of endometriotic stroma and epithelium underscore the importance of the lesional microenvironment and ever-changing cellular identity. Mutational profiling of normal endometrium from women of different ages and reproductive history is needed in order to gain a deeper understanding of the pathogenesis. Moreover, one area that has conspicuously received scant attention is the epigenetic landscape of ectopic, eutopic and normal endometrium.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Recently, molecular biology techniques using a next‐generation sequencing have also provided clues to the origin of endometriosis and pathogenesis that cannot be elucidated by epidemiological investigations alone.”
From Extra-pelvic endometriosis: a review. (2020) · cites this paper as [102]
Citations
Cites
Items 201–280 of 280
TGF-β1 epigenetically modifies Thy-1 expression in primary lung fibroblasts
Neveu, W. A., Mills, S. T., Staitieh, B. S., & Sueblinvong, V. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00086.2015 · Cited by 65
Cheng, C., Licence, D. R., Cook, E., Luo, F., Arends, M. J., Smith, S. K., Print, C. G., & Jones, D. S. (2011) · The Journal of Pathology · doi:10.1002/path.2852 · Cited by 63
Rocha, C. V., Broi, M. G. D., Furtado, C. L. M., Navarro, P. A., Ferriani, R. A., & Meola, J. (2019) · Reproductive Sciences · doi:10.1177/1933719119828078 · Cited by 63
Chene, G., Ouellet, V., Rahimi, K., Barrès, V., Provencher, D. M., & Mes‐Masson, A. (2015) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2015.02.021 · Cited by 62
Sarıdoğan, E. (2017) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.05.019 · Cited by 62
Different mutation profiles between epithelium and stroma in endometriosis and normal endometrium
Suda, K., Nakaoka, H., Yoshihara, K., Ishiguro, T., Adachi, S., Kase, H., Motoyama, T., Inoue, I., & Enomoto, T. (2019) · Human Reproduction · doi:10.1093/humrep/dez155 · Cited by 61
Genomic Alterations in Ectopic and Eutopic Endometria of Women with Endometriosis
Wu, Y., Strawn, E., Basir, Z., Wang, Y., Halverson, G., Jailwala, P., & Guo, S. (2006) · Gynecologic and Obstetric Investigation · doi:10.1159/000093130 · Cited by 60
Self-citationEvidence for a Hypercoagulable State in Women With Ovarian Endometriomas
Wu, Q., Ding, D., Liu, X., & Guo, S. (2015) · Reproductive Sciences · doi:10.1177/1933719115572478 · Cited by 60
Self-citationWu, L., Lv, C., Su, Y.-F., Li, C., Zhang, H., Zhao, X., & Li, M. (2018) · Gynecological Endocrinology · doi:10.1080/09513590.2018.1519787 · Cited by 60
Shin, J.-C., Ross, H. L., Elias, S., Nguyen, D. D., Mitchell‐Leef, D., Simpson, J. L., & Bischoff, F. Z. (1997) · Human Genetics · doi:10.1007/s004390050524 · Cited by 59
Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis
Guo, S. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12221 · Cited by 58
Self-citationThe presence of KRAS, PPP2R1A and ARID1A mutations in 101 Chinese samples with ovarian endometriosis
Zou, Y., Zhou, J., Guo, J.-B., Wang, L., Luo, Y., Zhang, Z., Liu, F., Tan, J., Wang, F., & Huang, O. (2018) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2018.03.001 · Cited by 57
SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
Wu, S., Fatkhutdinov, N., Fukumoto, T., Bitler, B. G., Park, P. H., Kossenkov, A. V., Trizzino, M., Tang, H., Zhang, L., Gardini, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06656-6 · Cited by 57
Boyle, D. P., & McCluggage, W. G. (2009) · Journal of Clinical Pathology · doi:10.1136/jcp.2008.064261 · Cited by 56
Increased levels of oxidative stress markers in the peritoneal fluid of women with endometriosis
Polak, G., Wertel, I., Barczyński, B., Kwaśniewski, W. M., Bednarek, W., & Kotarski, J. (2013) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2012.12.043 · Cited by 56
Pathogenetic role of the stromal cells in endometriosis and adenomyosis
Mai, K., Yazdi, H. M., Perkins, D. G., et al. (1997) · Histopathology · doi:10.1046/j.1365-2559.1997.4910725.x · Cited by 56
Amemiya, S., Sekizawa, A., Otsuka, J., Tachikawa, T., Saito, H., & Okai, T. (2004) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2004.04.036 · Cited by 56
Lakshminarasimhan, R., Andreu‐Vieyra, C., Lawrenson, K., Duymich, C. E., Gayther, S. A., Liang, G., & Jones, P. A. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.04.040 · Cited by 55
Oxidative Damage and Mitochondrial DNA Mutations with Endometriosis
Kao, S., HUANG, H., Hsieh, R., Chen, S., Tsai, M.-C., & Tzeng, C.-R. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1338.021 · Cited by 54
Westin, S. N., Ju, Z., Broaddus, R. R., Krakstad, C., Li, J., Pal, N., Lu, K. H., Coleman, R. L., Hennessy, B. T., Klempner, S. J., et al. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.04.014 · Cited by 52
Emergence, Involution, and Progression to Carcinoma of Mutant Clones in Normal Endometrial Tissues
Mutter, G. L., Monte, N. M., Neuberg, D. S., Ferenczy, A. S., & Eng, C. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0108 · Cited by 52
Colón-Caraballo, M., García, M., Mendoza, A., & Flores, I. (2018) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000663 · Cited by 52
Anterior Focal Adenomyosis and Bladder Deep Infiltrating Endometriosis, Is There a Link?
Marcellin, L., Santulli, P., Bortolato, S., Morin, C., Millischer, A. E., Borghese, B., & Chapron, C. (2018) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2018.02.002 · Cited by 51
Eutopic stromal cells of endometriosis promote neuroangiogenesis via exosome pathway†
Sun, H., Li, D., Yuan, M., Li, Q., Li, N., & Wang, G. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy212 · Cited by 51
Sensory nerve-derived neuropeptides accelerate the development and fibrogenesis of endometriosis
Liu, X., Yan, D., & Guo, S.-W. (2019) · Human Reproduction · doi:10.1093/humrep/dey392 · Cited by 51
Self-citationKamergorodsky, G., Ribeiro, P. A., Galvão, M. A. L., Abrão, M. S., Donadio, N., Lemos, N. L. D. B. M., & Aoki, T. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.05.086 · Cited by 49
Chegini, N., Gold, L. I., & Rs, W. (1994) · PubMed · Cited by 49
Wu, Y., Bu, F., Yu, H., Li, W., Huang, C., Meng, X., Zhang, L., Ma, T., & Li, J. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.12.002 · Cited by 49
Marcellin, L., Santulli, P., Chouzenoux, S., Cerles, O., Nicco, C., Dousset, B. E., Pallardy, M. J., Kerdine‐Römer, S., Just, P.-A., Chapron, C., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.362 · Cited by 48
Walankiewicz, M., Grywalska, E., Polak, G., Korona‐Głowniak, I., Witt, E., Surdacka, A., Kotarski, J., & Roliński, J. (2018) · Mediators of Inflammation · doi:10.1155/2018/7041342 · Cited by 48
Endometrial Cancer Risk Factors, Hormone Receptors, and Mortality Prediction
Busch, E. L., Crous‐Bou, M., Prescott, J., Chen, M. M., Downing, M. J., ROSNER, B. A., Mutter, G. L., & Vivo, I. D. (2017) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0821 · Cited by 47
The establishment of a mouse model of deep endometriosis
Yan, D., Liu, X., & Guo, S.-W. (2019) · Human Reproduction · doi:10.1093/humrep/dey361 · Cited by 47
Self-citationMatsuzaki, S., Darcha, C., Pouly, J. L., & Canis, M. J. (2017) · Scientific Reports · doi:10.1038/srep44616 · Cited by 46
Challenging estrogen receptor β with phosphorylation
Sanchez, M., Picard, N., Sauvé, K., & Tremblay, A. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.09.007 · Cited by 44
Zhou, Y., Zeng, C., Li, X., Wu, P., Yin, L., Yu, X., Zhou, Y., & Xue, Q. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1396-1 · Cited by 44
The Endometrial Response to Chorionic Gonadotropin Is Blunted in a Baboon Model of Endometriosis
Sherwin, J. R. A., Hastings, J. M., Jackson, K. S., Mavrogianis, P. A., Sharkey, A., & Fazleabas, A. T. (2010) · Endocrinology · doi:10.1210/en.2010-0275 · Cited by 43
Identifying neoantigens for use in immunotherapy
Hutchison, S., & Pritchard, A. L. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9771-6 · Cited by 42
Estrogen and progesterone receptors in smooth muscle component of deep infiltrating endometriosis
Noël, J.-C., Chapron, C., Bucella, D., Buxant, F., Peny, M.-O., Fayt, I., Borghese, B., & Anaf, V. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.12.114 · Cited by 41
Hapangama, D. K., Turner, M. A., Drury, J. A., Heathcote, L., Afshar, Y., Mavrogianis, P. A., & Fazleabas, A. T. (2010) · Human Reproduction · doi:10.1093/humrep/deq248 · Cited by 41
Circulating miRNAs in Murine Experimental Endometriosis: Decreased Abundance of let-7a
Seifer, B. J., Su, D., & Taylor, H. S. (2016) · Reproductive Sciences · doi:10.1177/1933719116667228 · Cited by 41
Oncogenic events associated with endometrial and ovarian cancers are rare in endometriosis
Vestergaard, A. L., Thorup, K., Knudsen, U. B., Munk, T., Rosbach, H. K., Poulsen, J. B., Guldberg, P., & Martensen, P. M. (2011) · Molecular Human Reproduction · doi:10.1093/molehr/gar049 · Cited by 39
Naqvi, H., Mamillapalli, R., Krikun, G., & Taylor, H. S. (2015) · Reproductive Sciences · doi:10.1177/1933719115613449 · Cited by 37
Sbracia, M., Scarpellini, F., Zupi, E., Manna, C., Marconi, D., Romaninï, C., Alò, P., Tondo, U. D., & Grasso, J. (1997) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1997.tb00238.x · Cited by 36
Magnetic resonance relaxation time in evaluating the cyst fluid characteristics of endometrioma
Takahashi, K., Okada, S., Okada, M., Kitao, M., Kaji, Y., & Sugimura, K. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019266 · Cited by 36
Guo, S., & Martin, D. C. (2019) · Human Reproduction · doi:10.1093/humrep/dez187 · Cited by 34
Self-citationKoh, H. B., Scruggs, A. M., & Huang, S. K. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.723080 · Cited by 33
Wang, L., Zhao, J., Li, Y., Wang, Z., & Kang, S. (2019) · Molecular Reproduction and Development · doi:10.1002/mrd.23127 · Cited by 33
Increased expression of CYP1A1 and CYP1B1 in ovarian/peritoneal endometriotic lesions
Piccinato, C. D. A., Neme, R. M., Torres, N., Sanches, L. R., Derogis, P. B. M. C., Brudniewski, H. F., Silva, J. C. R. E., & Ferriani, R. A. (2016) · Reproduction · doi:10.1530/rep-15-0581 · Cited by 32
Kuo, H.-H., Huang, C.-Y., Ueng, S., Huang, K., Lee, C., & Yen, C. (2017) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2015.09.009 · Cited by 32
Li, Q., Sun, Y., Zhang, X., Wang, L., Wu, W., Wu, M., Meng, C., & Liu, G. (2019) · Cancer Biology & Therapy · doi:10.1080/15384047.2019.1595278 · Cited by 30
Transforming Growth Factor‐β Isoforms and Receptors in Endometriotic Cysts of the Human Ovary
Tamura, M., Fukaya, T., Enomoto, A., Murakami, T., Uehara, S., & Yajima, A. (1999) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1999.tb00480.x · Cited by 29
Detection of DNA copy number changes in human endometriosis by comparative genomic hybridization
Gogusev, J., Joliniere, J. B. D., Telvi, L., et al. (1999) · Human Genetics · doi:10.1007/s004399900174 · Cited by 29
Epigenetic inactivation of hMLH1 in the malignant transformation of ovarian endometriosis
Ren, F., Wang, D., Jiang, Y., & Ren, F. (2011) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-011-1922-x · Cited by 28
Ding, D., Liu, X., & Guo, S. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.11.033 · Cited by 28
Self-citationQunyan, S., Ding, D., Liu, X., & Guo, S. (2016) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0154-0 · Cited by 28
Self-citationAn ex vivo model for functional studies of myofibroblasts
Kilarski, W. W., Jura, N., & Gerwins, P. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700255 · Cited by 26
Reduced Sympathetic Innervation in Endometriosis is Associated to Semaphorin 3C and 3F Expression
Scheerer, C., Frangini, S., Chiàntera, V., & Mechsner, S. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0058-1 · Cited by 24
Eutopic endometrium from women with endometriosis does not exhibit neurotrophic properties
Barcena, M. L., Arnold, J., Sacher, F., Bloechle, M., Staube, M., Bartley, J., Vercellino, G. F., Chiàntera, V., Schneider, A., & Mechsner, S. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.04.020 · Cited by 23
Involution of latent endometrial precancers by hormonal and nonhormonal mechanisms
Lin, M., Burkholder, K. A., Viswanathan, A. N., Neuberg, D. S., & Mutter, G. L. (2009) · Cancer · doi:10.1002/cncr.24218 · Cited by 22
Involvement of AP-1 proteins in pancreatic stellate cell activation in vitro
Fitzner, B., Sparmann, G. H., Emmrich, J. O. R., et al. (2004) · International Journal of Colorectal Disease · doi:10.1007/s00384-003-0565-1 · Cited by 22
Dewanto, A., Dudás, J., Glueckert, R., Mechsner, S., Schrott‐Fischer, A., Wildt, L., & Seeber, B. (2016) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0178-5 · Cited by 22
Souza-Pinto, N. C., Eide, L., Hogue, B. A., et al. (2001) · Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) · Cited by 22
Histological evaluation of the prevalence of adenomyosis, myomas and of their concomitance
Filip, G., Balzano, A., & Cagnacci, A. (2019) · Minerva Obstetrics and Gynecology · doi:10.23736/s0026-4784.18.04291-0 · Cited by 21
Medical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment
Ersoy, G. Ş., Zolbin, M. M., Çoşar, E., Mamillapalli, R., & Taylor, H. S. (2017) · Reproductive Sciences · doi:10.1177/1933719116682879 · Cited by 20
Yang, W., Zhang, Y., Fu, F., & Li, R. (2013) · Gynecological Endocrinology · doi:10.3109/09513590.2013.788632 · Cited by 18
Saare, M., Sõritsa, D., Vaidla, K., Palta, P., Remm, M., Laan, M., Karro, H., Sõritsa, A., Salumets, A., D’Hooghe, T. M., et al. (2012) · Human Reproduction · doi:10.1093/humrep/des125 · Cited by 18
He, Z., Shi, H., Fan, Q., et al. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0343-2 · Cited by 18
Endometriosis-Derived Thromboxane A2 Induces Neurite Outgrowth
Yan, D., Liu, X., & Guo, S.-W. (2017) · Reproductive Sciences · doi:10.1177/1933719116670037 · Cited by 17
Self-citationBisulfite-converted duplexes for the strand-specific detection and quantification of rare mutations
Mattox, A. K., Wang, Y., Springer, S. U., Cohen, J. D., Yegnasubramanian, S., Nelson, W. G., Kinzler, K. W., Vogelstein, B., & Papadopoulos, N. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701382114 · Cited by 17
Lac, V., & Huntsman, D. D. (2018) · The Journal of Pathology · doi:10.1002/path.5136 · Cited by 17
Gagliardi, M., Maynard, S., Miyake, T., Rodrigues, N., Tjew, S. L., Cabannes, É., & Bédard, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304085200 · Cited by 16
diZerega, G. S., Marrs, R. P., Løbo, R. A., Ujita, E. L., Brown, J. B., & Campeau, J. D. (1984) · Fertility and Sterility · doi:10.1016/s0015-0282(16)47897-0 · Cited by 16
Kitano, T., Matsumoto, T., Takeuchi, H., Kikuchi, I., Itoga, T., Sasahara, N., & Kinoshita, K. (2007) · International Journal of Gynecological Pathology · doi:10.1097/01.pgp.0000235067.16054.dd · Cited by 15
Targeting Neoantigens for Personalised Immunotherapy
Pritchard, A. L. (2018) · BioDrugs · doi:10.1007/s40259-018-0267-4 · Cited by 14
Nassif, J., Abbasi, S. A., Nassar, A. H., et al. (2016) · PubMed · Cited by 11
Liu, X., Yuan, L., Shen, F., & Guo, S. (2008) · Gynecologic and Obstetric Investigation · doi:10.1159/000127419 · Cited by 10
Self-citationReconstructing cellular lineages in endometrial cells
Wu, Y., & Guo, S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.03.028 · Cited by 10
Self-citationEpigenetic Mechanisms of Pancreatobiliary Fibrosis
Aseem, S. O., & Huebert, R. C. (2019) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-019-00239-0 · Cited by 6
Rai, P., Deenadayal, M., & Shivaji, S. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.04.022 · Cited by 5
Somatic driver mutations in endometriosis as possible regulators of fibrogenesis (Review)
Kobayashi, H. (2019) · World Academy of Sciences Journal · doi:10.3892/wasj.2019.12 · Cited by 4
Flagged first, then by citations
Cited by
Sorted by citations
Extra-pelvic endometriosis: a review.
Hirata, T., Koga, K., & Osuga, Y. (2020) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12340 · Cited by 107
The Double Engines and Single Checkpoint Theory of Endometriosis
Hsu, C.-F., Khine, A. A., Huang, H.-S., & Chu, T.-Y. (2022) · Biomedicines · doi:10.3390/biomedicines10061403 · Cited by 12
Metadata
- Authors
- Guo, S.-W.
- Affiliations
- Fudan University (CN)
- Corresponding author
- Guo, Sun-Wei
- ORCID
- Guo, Sun-Wei
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-03-10
- Volume
- 26
- Issue
- 3
- Pages
- 423-449
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W3011721387
- Cited by
- 96
- References
- 280
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 8 · 2023: 15 · 2022: 20 · 2021: 13 · 2020: 10
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation of China (81771553, 81530040)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Plant and fungal interactions
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometriosis, cancer-associated mutations, somatic mutations, deep infiltrating endometriosis, endometriotic lesions, endometriosis pathogenesis, endometriosis pathophysiology, ectopic endometrium, eutopic endometrium, replicative senescence, oxidative stress, fibrosis, epigenetics, oestrogen receptor, ARID1A mutation, KRAS mutation, carcinogenesis
- MeSH terms
- Bone Marrow Cells, Endometriosis, Endometrium, Epithelial Cells, Female, Humans, Mutation, Neoplasms, Ovarian Diseases, Epithelial-Mesenchymal Transition, Tumor Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
