Estrogen and progesterone receptors in smooth muscle component of deep infiltrating endometriosis
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Objective To analyze the expression of estrogen (ER) and progesterone (PR) receptors in the smooth muscle component (SMC) of deep infiltrating endometriosis (DIE).Design A prospective clinical and pathologic study of 60 cases of DIE.Setting University Hospital Department of Gynacology.Patient(s) Sixty patients with symptomatic DIE (uterosacral endometriosis n = 14; bladder endometriosis n = 10; colonic endometriosis n = 16; rectovaginal endometriosis n = 20).Intervention(s) Laparoscopic surgery.Main outcome measure(s) The expression of ER and PR was studied by immunohistochemistry in the SMC directly around endometriotic foci and at distance (at least >1.5 cm) from them in correlation with proliferative and secretory phases of cycle.Results The ER and PR were present in the SMC of DEI in each location excepting colonic endometriosis where ER were absent. Independently of cycle's phases the PR were more abundant than ER. With the exception of rectovaginal endometriosis, where the ER and PR were more abundant in the proliferative than in the secretory phase, in other locations the ER and PR did not differ significantly with cycle's phases. Last, if ER and PR were more abundant in SMC around endometriotic foci than at a distance from them. However, the difference was not significant.Conclusions Our data substantially confirm for the first time that in various forms of DIE, ER and PR are present not only in glands and stroma but also in the smooth muscle major histologic component of this disease.
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Progesterone receptors are present in major histologic components of colon endometriosis, including the smooth muscle fibers.
“Noël et al . demonstrated that progesterone receptors were present in major histologic components of colon endometriosis, including the smooth muscle fibers (45).”
From Medical treatment in the management of deep endometriosis infiltrating the proximal rectum and sigmoid colon: a comprehensive literature review (2018) · cites this paper as Noël et al. (45)
The receptor pattern and biologic behaviour of eutopic and ectopic endometrium are substantially similar.
“the receptor pattern and the biologic behaviour of the two mucosae are substantially similar (Noel et al., 2010)”
From “Waiting for Godot”: a commonsense approach to the medical treatment of endometriosis (2011) · cites this paper as Noel et al., 2010
Endometriosis appears to originate from intrauterine endometrium.
“endometriosis appears to originate from intrauterine endometrium”
From “Waiting for Godot”: a commonsense approach to the medical treatment of endometriosis (2011) · cites this paper as Noel et al., 2010
ERs and PRs are present not only in glands and stroma but also in the smooth muscle component of deep endometriosis, and the expression of a-smooth muscle actin and collagen I in and around endometriotic lesions support the notion of the metaplastic process.
“That E receptors (ERs) and PRs are present not only in glands and stroma but also in the smooth muscle component of deep endometriosis (229), and the expression of a-smooth muscle actin and collagen I in and around endometriotic lesions support the notion of the metaplastic process (230).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [229]
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- Authors
- Noël, J.-C., Chapron, C., Bucella, D., Buxant, F., Peny, M.-O., Fayt, I., Borghese, B., & Anaf, V.
- Affiliations
- Université Libre de Bruxelles (BE)
- Hôpital Cochin (FR)
- Hôpital de Jolimont (BE)
- Corresponding author
- Noël, Jean-Christophe
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 93
- Issue
- 6
- Pages
- 1774-1777
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1982532500
- Cited by
- 41
- References
- 25
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Keywords
- deep infiltrating endometriosis, estrogen receptor, progesterone receptor, menstrual cycle phases, proliferative phase, luteal phase, bladder endometriosis, colonic endometriosis, rectovaginal endometriosis, immunohistochemistry
- MeSH terms
- Urinary Bladder Diseases, Endometriosis, Female, Follicular Phase, Humans, Intestinal Diseases, Luteal Phase, Muscle, Smooth, Receptors, Estrogen, Receptors, Progesterone, Stromal Cells
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